|
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
eNOS gene intron 4 VNTR and exon 7-G894T polymorphisms in Turkish men with erectile dysfunction: a case control study.
|
19473288 |
2009 |
|
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
ACE and NOS3 genotypes were determined in patients with ED and in 108 healthy male blood donors.
|
12837457 |
2003 |
|
Erectile dysfunction
|
0.600 |
Therapeutic
|
disease |
CTD_human |
Altered growth factor expression in the aging penis: the Brown-Norway rat model.
|
12002441 |
2002 |
|
Erectile dysfunction
|
0.600 |
Biomarker
|
disease |
CTD_human |
Altered growth factor expression in the aging penis: the Brown-Norway rat model.
|
12002441 |
2002 |
|
Erectile dysfunction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of the expression of the P2Y1, P2Y2, P2Y4, and P2Y6 receptors that reduces the ratio of phosphorylated eNOS/eNOS and eNOS activity may be one of the important mechanisms of erectile dysfunction caused by low androgen status.
|
29596864 |
2018 |
|
Erectile dysfunction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Electromagnetic cylinder ESWT device resulted in increased VEGF, nNOS, and eNOS expression; reduced smooth muscle atrophy; and increased endothelial cell regeneration in a DM-associated ED model.
|
29164834 |
2017 |
|
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Five genetic models and a generalized odds ratio (OR(G) ) were used to estimate the association between eNOS G894T and variable number of 27-bp tandem repeats in intron 4 (4 VNTR) and the risk of ED.
|
20722785 |
2010 |
|
Erectile dysfunction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Gene therapy to the penile corpora cavernosa of cDNAs expressing PnNOS or eNOS, or counteracting PIN, has been effective in ameliorating ED in the aging rat model that exhibits both neurogenic ED and CVOD. cDNA constructs for other genes involved in the control of penile erection have also been successfully tested.
|
15582286 |
2005 |
|
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, an association between eNOS G894T polymorphism and ED risk is uncertain and should be updated.
|
25726156 |
2015 |
|
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, there has been no report investigating the eNOS G894T genetic susceptibility factor for both ED and BPH/LUTS.
|
19515207 |
2009 |
|
Erectile dysfunction
|
0.600 |
Biomarker
|
disease |
RGD |
In addition, ED was associated with decreased eNOS protein expression at both ages.
|
20807325 |
2010 |
|
Erectile dysfunction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In contrast, chronic alcohol administration changed the ultrastructures of the CC and suppressed eNOS expression, thereby leading to erectile dysfunction.
|
28064474 |
2017 |
|
Erectile dysfunction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Inflammatory and vascular parameters including myeloperoxidase (MPO), cyclooxygenase2 (COX2), endothelial nitric oxide synthase (eNOS), malondialdehyde (MDA), superoxide dismutase (SOD), reactive oxygen species (ROS), and cytokines in treated and untreated ED rats were measured.
|
30484894 |
2018 |
|
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Neither of the eNOS polymorphisms, G894T or T-786C, was significantly associated with sexual or erectile dysfunction.
|
21749219 |
2011 |
|
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis showed that the two single nucleotide polymorphisms in eNOS gene, G894T and T-786C, are strongly associated with the risk of erectile dysfunction.
|
26908069 |
2018 |
|
Erectile dysfunction
|
0.600 |
Biomarker
|
disease |
RGD |
Peripheral mechanisms of erectile dysfunction in a rat model of chronic cocaine use.
|
17420087 |
2007 |
|
Erectile dysfunction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Putative gene therapy interventions to restore eNOS expression and subsequent endothelial function may represent an exciting new therapeutic strategy for the future treatment of ED.
|
16378511 |
2005 |
|
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Several studies have focused on the impaired role of endothelial nitric oxide synthase (NOS3) gene polymorphism and its association to erectile dysfunction (ED).
|
30977424 |
2019 |
|
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The ec-NOS gene intron 4 VNTR, E298A and IVF 23+10 G/T polymorphisms were evaluated in the isolated DNA blood samples obtained from the patient group with ED (n=96), from the group received sildenafil (n=67) and from the healthy group (n=167).
|
16871271 |
2007 |
|
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The eNOS 894T allele carriers are at greater risk for both MtS and ED, suggesting that eNOS G894T gene polymorphism might play an implication as a common genetic susceptibility factor to develop both disorders.
|
22304542 |
2012 |
|
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of this prospective study is to evaluate the relationship between polymorphism of eNOS gene and erectile dysfunction (ED).
|
16409219 |
2006 |
|
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The CC genotype of T-786C polymorphism in the promoter of eNOS gene is associated with increased risk of ED in Turkish population.
|
19800665 |
2010 |
|
Erectile dysfunction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The decrease in the expression of endothelial NOS and NOS activity in penile cavernous tissue caused by systemic inflammatory and oxidative stress status induced by exposure to PM<sub>2.5</sub> may be one of the important risk factors of erectile dysfunction.
|
27592525 |
2017 |
|
Erectile dysfunction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The diabetic control group showed higher cGMP production level transcription and protein levels of eNOS and DKK3 and lower production levels of AGEs and miR-328 than the diabetic ED and diabetic ED+NC groups.
|
28599252 |
2017 |
|
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The distributions of alleles (G894T, P < .005; T-786C, P < .015), genotypes (G894T, P < 0.015; T-786C, P < .010), and haplotypes (G894T/T-786C, P < .015) of the NOS3 polymorphisms were significantly different between patients with ED and controls.
|
28268155 |
2017 |