Erectile dysfunction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In contrast, chronic alcohol administration changed the ultrastructures of the CC and suppressed eNOS expression, thereby leading to erectile dysfunction.
|
28064474 |
2017 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Neither of the eNOS polymorphisms, G894T or T-786C, was significantly associated with sexual or erectile dysfunction.
|
21749219 |
2011 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The ec-NOS gene intron 4 VNTR, E298A and IVF 23+10 G/T polymorphisms were evaluated in the isolated DNA blood samples obtained from the patient group with ED (n=96), from the group received sildenafil (n=67) and from the healthy group (n=167).
|
16871271 |
2007 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
ACE and NOS3 genotypes were determined in patients with ED and in 108 healthy male blood donors.
|
12837457 |
2003 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We performed a meta-analysis of published studies investigating the association between ED and three eNOS polymorphisms, intron 4 VNTR, G894T and T786C in humans.
|
29654965 |
2018 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, an association between eNOS G894T polymorphism and ED risk is uncertain and should be updated.
|
25726156 |
2015 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis showed that the two single nucleotide polymorphisms in eNOS gene, G894T and T-786C, are strongly associated with the risk of erectile dysfunction.
|
26908069 |
2018 |
Erectile dysfunction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These findings support that UCMS decreases penile constitutive NOS expression via TNF-α, which may contribute to the development of ED.
|
27904147 |
2017 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To evaluate a potential association between the G894T polymorphism in the eNOS gene and ED complaints in a population-based sample in São Paulo, Brazil.
|
19968769 |
2010 |
Erectile dysfunction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of the expression of the P2Y1, P2Y2, P2Y4, and P2Y6 receptors that reduces the ratio of phosphorylated eNOS/eNOS and eNOS activity may be one of the important mechanisms of erectile dysfunction caused by low androgen status.
|
29596864 |
2018 |
Erectile dysfunction
|
0.600 |
Biomarker
|
disease |
BEFREE |
The oxidative stress biochemical markers were attenuated, while eNOS and SOD<sub>EX</sub> mRNA expression were restored in atorvastatin and sildenafil groups, which were found to be involved in ED pathogenesis.
|
28295458 |
2017 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The eNOS 894T allele carriers are at greater risk for both MtS and ED, suggesting that eNOS G894T gene polymorphism might play an implication as a common genetic susceptibility factor to develop both disorders.
|
22304542 |
2012 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The distributions of alleles (G894T, P < .005; T-786C, P < .015), genotypes (G894T, P < 0.015; T-786C, P < .010), and haplotypes (G894T/T-786C, P < .015) of the NOS3 polymorphisms were significantly different between patients with ED and controls.
|
28268155 |
2017 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to determine the relationship between erectile dysfunction (ED), coronary artery disease (CAD), and T(-786)C and intron 4 a/b endothelial nitric oxide synthase (eNOS) polymorphisms in 419 patients with suspected or known CAD referred for coronary angiography.
|
19466514 |
2009 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, there has been no report investigating the eNOS G894T genetic susceptibility factor for both ED and BPH/LUTS.
|
19515207 |
2009 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
eNOS gene intron 4 VNTR and exon 7-G894T polymorphisms in Turkish men with erectile dysfunction: a case control study.
|
19473288 |
2009 |
Erectile dysfunction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Putative gene therapy interventions to restore eNOS expression and subsequent endothelial function may represent an exciting new therapeutic strategy for the future treatment of ED.
|
16378511 |
2005 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of this prospective study is to evaluate the relationship between polymorphism of eNOS gene and erectile dysfunction (ED).
|
16409219 |
2006 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Five genetic models and a generalized odds ratio (OR(G) ) were used to estimate the association between eNOS G894T and variable number of 27-bp tandem repeats in intron 4 (4 VNTR) and the risk of ED.
|
20722785 |
2010 |
Erectile dysfunction
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Electromagnetic cylinder ESWT device resulted in increased VEGF, nNOS, and eNOS expression; reduced smooth muscle atrophy; and increased endothelial cell regeneration in a DM-associated ED model.
|
29164834 |
2017 |
Erectile dysfunction
|
0.600 |
Biomarker
|
disease |
BEFREE |
We investigated the relationship between gene polymorphism in the angiotensin converting enzyme (ACE) or endothelial nitric oxide synthase (ecNOS) and development of erectile dysfunction.
|
10553806 |
1999 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We performed a meta-analysis to estimate the association between eNOS polymorphisms and ED risk.
|
25940782 |
2015 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The CC genotype of T-786C polymorphism in the promoter of eNOS gene is associated with increased risk of ED in Turkish population.
|
19800665 |
2010 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Several studies have focused on the impaired role of endothelial nitric oxide synthase (NOS3) gene polymorphism and its association to erectile dysfunction (ED).
|
30977424 |
2019 |
Erectile dysfunction
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We studied 118 patients; 63 patients had ED secondary to radical prostatectomy (PED) and 55 had organic, clinical ED. eNOS genotypes for three eNOS polymorphisms (T(-786)C, rs2070744; a variable number of tandem repeats (VNTR) in intron 4; and rs1799983" genes_norm="4846">Glu298Asp, rs1799983) were determined, and eNOS haplotypes were estimated using PHASE 2.1.
|
22064666 |
2013 |