|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The present study suggested an association between a G894T polymorphism of eNOS gene and EH in Hani and Yi minority groups of China.
|
18164968 |
2008 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
MGD |
Coronary hemodynamics in endothelial NO synthase knockout mice.
|
9468189 |
1998 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to assess the potential impact of obesity, and angiotensin-converting enzyme (ACE) I/D polymorphism and endothelial nitric oxide synthase gene (NOS3) 4a/4b, G894T and -T786C variants on the essential hypertension.
|
26579574 |
2015 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To explore the genetic involvement of the eNOS gene in essential hypertension, we examined the possible association between essential hypertension and several polymorphisms including the Glu298Asp variant, variable number tandem repeats in intron 4 (eNOS4b/4a), and two polymorphisms in introns 18 and 23.
|
9674630 |
1998 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Abstract Background: The G894T (rs1799983) polymorphism in endothelial nitric oxide synthase (eNOS/NOS3) gene has been implicated in susceptibility to essential hypertension (EH) in some studies, but no clear consensus has been reached in the Chinese population.
|
24846690 |
2015 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Endothelial nitric oxide synthase gene polymorphisms and essential hypertension in Han Chinese.
|
20882485 |
2010 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
MGD |
Infarct size and nitric oxide synthase in murine myocardium.
|
10652188 |
2000 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Taken together, our results do not support the previous observation that the molecular variant of the eNOS gene may confer principal susceptibility for essential hypertension but rather suggest the existence of sampling variation.
|
10205226 |
1999 |
|
Essential Hypertension
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Collectively, these data indicate that HCMV may contribute to EH development in the Kazakh Chinese by increasing TNF-α and 8-OHDG levels, suppressing eNOS and renin, and manipulating <i>HSD3B2</i> and <i>ACE</i> methylation.
|
29752343 |
2018 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The eNOS T allele is not more prevalent among hypertensive children than among healthy ones, but it is associated with early vascular damage in children with PH, independent of metabolic abnormalities.
|
26227630 |
2015 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
MGD |
Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms.
|
16024729 |
2005 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
BEFREE |
A role for NOS3 in onset of essential hypertension (HT) is, however, controversial.
|
10981549 |
2000 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
BEFREE |
To determine whether the endothelial nitric oxide synthase gene is involved in human essential hypertension, we identified informative biallelic and multiallelic markers of this locus and performed case-control and linkage studies in hypertensive subjects and normotensive control subjects.
|
7528648 |
1995 |
|
Essential Hypertension
|
0.600 |
Biomarker
|
disease |
MGD |
Hypertension in mice lacking the gene for endothelial nitric oxide synthase.
|
7545787 |
1995 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Searching for phenotypic expression of eNOS gene variants, we genotyped a group of patients with essential hypertension (H, n = 119) for the Glu298Asp polymorphism and compared them with age- and sex-matched healthy normals (N, n = 85).
|
11394896 |
2001 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the eNOS polymorphism is one of the factors contributing to the predisposition for essential hypertension in the Han population in southwestern China.
|
21968727 |
2011 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The purpose of the present study was to determine whether three common variants in NOS3 (the eNOS gene) are associated with the risk of LVH [LV (left ventricular) hypertrophy] in patients with essential hypertension.
|
19132956 |
2009 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Evidence for the involvement of eNOS single nucleotide polymorphisms in the development of essential hypertension is limited, though the eNOS Glu298Asp polymorphism appears to influence the blood pressure response to exercise.
|
12530931 |
2003 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of rs1799983 (G>T) and rs1800780 (A>G) of the eNOS gene associated with susceptibility to essential hypertension in the Chinese Hui ethnic population.
|
23613274 |
2013 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Essential hypertension patients were genotyped for 11 polymorphisms of essential hypertension susceptibility genes including ADD1 (rs4961), GNB3 (rs5443, rs16932941), NOS3 (rs1799983, rs2070744), ACE (rs5186), AGTR1 (rs5186), AGT (rs699, rs4762), MR (rs5534), and TGFB1 (rs1800471).
|
26335431 |
2015 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The study results suggest that the three eNOS gene polymorphisms are unlikely to be major genetic susceptibility factors for essential hypertension in the northern Han Chinese population.
|
16834924 |
2006 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To further investigate the genetic involvement of the eNOS gene in essential hypertension, we examined the frequency of T-786-->C variant in two independent populations of persons with essential hypertension in Kyoto (n=215) and Kumamoto (n=186) and compared the frequency with that in each age- and gender-matched control (233 controls in Kyoto and 223 controls in Kumamoto).
|
11131266 |
2000 |
|
Essential Hypertension
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our findings argue against an association between ecNOS polymorphism and preeclampsia and support the hypothesis for a different pathogenesis of GH in respect to EH.
|
12908999 |
2003 |