|
Lupus Erythematosus, Systemic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis suggests that TLR7, TLR8, and TLR9 polymorphisms are associated with the development of SLE in Caucasian, Asian, and African populations.
|
26762473 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here, we conducted trans-ancestral fine-mapping in 13,339 subjects including European Americans, African Americans, and Amerindian/Hispanics and confirmed rs3853839 as the only variant within the TLR7-TLR8 region exhibiting consistent and independent association with SLE (Pmeta = 7.5×10(-11), OR = 1.24 [1.18-1.34]).
|
23468661 |
2013 |
|
Lupus Erythematosus, Systemic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The "G-G" haplotype of TLR7 rs3853839 and TLR8 rs3764880 increased risk of SLE in females (age adjusted p = 0.0032).
|
24445780 |
2014 |
|
Lupus Erythematosus, Systemic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, no association was found between the rs5744168 (TLR5) polymorphism and SLE susceptibility in Europeans or between the rs187084 (TLR8) or rs352140 (TLR9) polymorphisms and SLE susceptibility in Asians.
|
22325161 |
2012 |
|
Tuberculosis, Pulmonary
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The results demonstrated that the frequency of the TLR8-129C allele was higher in male patients with pulmonary TB than in healthy controls (22.9% vs. 6.8%, p < 0.001).
|
27156628 |
2016 |
|
Tuberculosis, Pulmonary
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Our results indicate a role of a CD40LG variant and its combined effects with distinct TLR8 and IRAK1 variants in susceptibility to pTB in males.
|
26043172 |
2015 |
|
Tuberculosis, Pulmonary
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The frequencies of the GG genotype of SNP rs7873784 in TLR4 (OR = 2.136; 95% CI: 1.312-3.478) and the CC genotype of rs3764879 in TLR8 (OR = 1.982; 95% CI: 1.292-3.042) were also significantly higher in the PTB group than in the HC group.
|
25928077 |
2015 |
|
Tuberculosis, Pulmonary
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
TLR8 gene polymorphism and association in bacterial load in southern Punjab of Pakistan: an association study with pulmonary tuberculosis.
|
25572425 |
2015 |
|
Tuberculosis, Pulmonary
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
In summary, we show an association of SNP TLR8 rs3764880 with PTB in the Moldavian male population, providing support to previous studies conducted on other populations.
|
30529560 |
2019 |
|
Hepatitis C
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
The C allele is protective of HCV in TLR3, TLR7 (rs3853839) in females only, and TLR8 (rs3764879) in males only, while risk of infection is linked to the T allele in TLR7 (rs179008) in females only and the A allele in TLR8 (rs3764880) in both sexes.
|
29947302 |
2018 |
|
Hepatitis C
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
The aim was to estimate the association of TLR8 polymorphisms with HCV-related outcomes in HIV/HCV coinfected patients.
|
26455634 |
2015 |
|
Hepatitis C
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Our previous study demonstrated that the TLR8-129G>C (rs3764879) and TLR8+1G>A (rs3764880) variants were in complete linkage disequilibrium, and that the frequency of TLR8-129C/+1A was significantly higher in male patients with HCV infection compared with the healthy controls.
|
24205871 |
2014 |
|
Hepatitis C
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that variations in TLR7 and TLR8 genes modulate the clearance and progression of HCV infection with different magnitudes between sexes.
|
28752959 |
2018 |
|
Neoplasms
|
0.050 |
GeneticVariation
|
group |
BEFREE |
We previously reported that TLR8 expression was increased directly by the tumor suppressor and transcription factor p53 via a single nucleotide polymorphism (SNP) (rs3761624) in the TLR8 promoter, thereby placing TLR8 in the p53/immune axis.
|
31430261 |
2019 |
|
Tuberculosis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We found that four polymorphisms in the TLR8 gene on chromosome X showed evidence of association with TB susceptibility in males, including a non-synonymous polymorphism rs3764880 (Met1Val; P = 0.007, odds ratio (OR) = 1.8, 95% c.i.= 1.2-2.7).
|
18927625 |
2008 |
|
Tuberculosis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The A-allele of TLR8 rs3764880 SNP was protective against the development of TB in males (A vs G, OR = 0.58, 95%CI = 0.37-0.91).
|
30424735 |
2018 |
|
Tuberculosis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Association of toll-like receptors with susceptibility to tuberculosis suggests sex-specific effects of TLR8 polymorphisms.
|
26160538 |
2015 |
|
Tuberculosis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, these findings provide evidence that TLR7 and TLR8 genetic polymorphisms are associated with susceptibility to MTB infection, and the link is shaped by less effective MTB phagocytosis and impaired TLR signaling.
|
27156628 |
2016 |
|
Rheumatoid Arthritis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Here we showed that a quarter to a third of men with rheumatoid arthritis (RA) had significantly increased copy numbers (CN) of TLR7 gene and its paralog TLR8.
|
31501466 |
2019 |
|
Rheumatoid Arthritis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
We focussed on three single allelic variants, N248S in TLR1, Q11L in TLR7 and M1V in TLR8 based on the allelic frequencies in both patient and control populations, the predicted impact on protein function and the novelty in RA research.
|
28495399 |
2017 |
|
Crohn Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Association of haplotypes of the TLR8 locus with susceptibility to Crohn's and Behçet's diseases.
|
26486764 |
2016 |
|
Crohn Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Both "risk (H4)" and "protective (H1)" TLR8 haplotypes were observed associated with CD in females.
|
18942751 |
2009 |
|
Virus Diseases
|
0.030 |
GeneticVariation
|
group |
LHGDN |
This first report of a functional TLR8 variant associated with a different clinical course of an RNA viral disease may have implications for the individual risk assessment of patients infected with HIV and other RNA viruses as well as for future HIV vaccine development.
|
18605904 |
2008 |
|
Rhinovirus infection
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
TLR8 polymorphisms were associated with an increased risk and TLR7 polymorphisms with a decreased risk of recurrent rhinovirus infections (P = 0.02 for both).
|
28403045 |
2017 |
|
Allergic rhinitis (disorder)
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The first association analysis identified 4 allergic rhinitis-associated SNPs in the TLR7-TLR8 gene region.
|
22857391 |
2012 |