TLR8, toll like receptor 8, 51311

N. diseases: 122; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0022602
Disease: Actinic keratosis
Actinic keratosis 		0.010 AlteredExpression disease BEFREE Comparing uninvolved skin and untreated AK, we found significant differences in the expression of interleukin (IL)-6, hurpin, TLR7 and TLR8. 15606509 2004
CUI: C1519680
Disease: Tumor Immunity
Tumor Immunity 		0.010 Biomarker phenotype BEFREE Adoptive transfer of TLR8 ligand-stimulated Treg cells into tumor-bearing mice enhanced anti-tumor immunity. 16123302 2005
CUI: C0011991
Disease: Diarrhea
Diarrhea 		0.010 AlteredExpression phenotype BEFREE After 3 days of illness onset, only TLR3 and TLR8 mRNA expressions were still significantly (P<0.05) increased in 59% (44/75) children with diarrhoea. 16734605 2006
CUI: C0035869
Disease: Rotavirus Infections
Rotavirus Infections 		0.010 AlteredExpression group BEFREE To understand virus and host interactions and host responses to rotavirus infection in children, we analysed by real-time polymerase chain reaction (PCR) the expression of mRNA for five Toll-like receptors (TLRs) (TLR2, TLR3, TLR4, TLR7 and TLR8) and four T helper (Th)1 and Th2 cytokines [interleukin (IL)-2, IL-12, interferon (IFN)-gamma and IL-4) in peripheral blood mononuclear cells (PBMC) of children with acute rotavirus diarrhoea. 16734605 2006
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.030 Biomarker group BEFREE These experiments of nature suggest that the TLR7-, TLR8-, and TLR9-dependent induction of IFN-alpha, IFN-beta, and IFN-lambda is largely redundant in human antiviral immunity, whereas the TLR3-dependent induction of IFN-alpha, IFN-beta, and IFN-lambda is critical for primary immunity to HSV-1 in the central nervous system in children but redundant for immunity to most other viral infections. 17979850 2007
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.030 Biomarker group BEFREE Lack of functioning Btk in XLA patients downstream of TLR8 and TLR9 might explain the susceptibility of XLA patients to viral infections. 17932028 2007
CUI: C0221026
Disease: X-linked agammaglobulinemia
X-linked agammaglobulinemia 		0.020 Biomarker disease BEFREE Lack of functioning Btk in XLA patients downstream of TLR8 and TLR9 might explain the susceptibility of XLA patients to viral infections. 17932028 2007
CUI: C0221026
Disease: X-linked agammaglobulinemia
X-linked agammaglobulinemia 		0.020 Biomarker disease BEFREE Impaired Toll-like receptor 8-mediated IL-6 and TNF-alpha production in antigen-presenting cells from patients with X-linked agammaglobulinemia. 17090647 2007
CUI: C0001768
Disease: Agammaglobulinemia
Agammaglobulinemia 		0.010 AlteredExpression disease LHGDN Impaired Toll-like receptor 8-mediated IL-6 and TNF-alpha production in antigen-presenting cells from patients with X-linked agammaglobulinemia. 17090647 2007
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.010 Biomarker group BEFREE Our study shows that like CD4(+)CD25(+) Treg cells, CD8(+) Foxp3(+) Treg cells present in prostate tumor-derived TILs suppress immune responses and that their suppressive function can be regulated by TLR8 ligands, raising the possibility that the manipulation of Treg cell function by TLR8 ligands could improve the efficacy of immunotherapy for prostate cancer patients. 18056169 2007
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.010 Biomarker disease BEFREE Our study shows that like CD4(+)CD25(+) Treg cells, CD8(+) Foxp3(+) Treg cells present in prostate tumor-derived TILs suppress immune responses and that their suppressive function can be regulated by TLR8 ligands, raising the possibility that the manipulation of Treg cell function by TLR8 ligands could improve the efficacy of immunotherapy for prostate cancer patients. 18056169 2007
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.010 Biomarker disease BEFREE Our study shows that like CD4(+)CD25(+) Treg cells, CD8(+) Foxp3(+) Treg cells present in prostate tumor-derived TILs suppress immune responses and that their suppressive function can be regulated by TLR8 ligands, raising the possibility that the manipulation of Treg cell function by TLR8 ligands could improve the efficacy of immunotherapy for prostate cancer patients. 18056169 2007
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary 		0.090 Biomarker disease BEFREE Taken together, our results provide evidence, for the first time, of a role for the TLR8 gene in susceptibility to pulmonary TB across different populations. 18927625 2008
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.040 GeneticVariation disease BEFREE We found that four polymorphisms in the TLR8 gene on chromosome X showed evidence of association with TB susceptibility in males, including a non-synonymous polymorphism rs3764880 (Met1Val; P = 0.007, odds ratio (OR) = 1.8, 95% c.i.= 1.2-2.7). 18927625 2008
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.030 Biomarker disease LHGDN Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures. 19017992 2008
CUI: C0042769
Disease: Virus Diseases
Virus Diseases 		0.030 GeneticVariation group LHGDN This first report of a functional TLR8 variant associated with a different clinical course of an RNA viral disease may have implications for the individual risk assessment of patients infected with HIV and other RNA viruses as well as for future HIV vaccine development. 18605904 2008
CUI: C0004096
Disease: Asthma
Asthma 		0.020 GeneticVariation disease BEFREE The most significant association was seen for rs2407992 (TLR8) in asthma (p = 0.00023, sample A and B combined, recessive model). 18682521 2008
CUI: C0004096
Disease: Asthma
Asthma 		0.020 GeneticVariation disease LHGDN The most significant association was seen for rs2407992 (TLR8) in asthma (p = 0.00023, sample A and B combined, recessive model). 18682521 2008
CUI: C3854222
Disease: Human immunodeficiency virus (HIV) II infection category B1
Human immunodeficiency virus (HIV) II infection category B1 		0.020 GeneticVariation disease BEFREE This first report of a functional TLR8 variant associated with a different clinical course of an RNA viral disease may have implications for the individual risk assessment of patients infected with HIV and other RNA viruses as well as for future HIV vaccine development. 18605904 2008
CUI: C0019693
Disease: HIV Infections
HIV Infections 		0.010 GeneticVariation group BEFREE Presently, very little is known about the influence of TLR8 genetic variation on susceptibility to and progression of HIV disease. 18605904 2008
CUI: C0947961
Disease: Atopic disorders
Atopic disorders 		0.010 Biomarker group BEFREE By genome scanning, evidence of linkage between chromosome Xp22 and asthma and related atopic disorders has previously been obtained.Xp22 harbours the TLR7 and TLR8 genes. 18682521 2008
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.100 Biomarker disease BEFREE We have found that seven of these genes exhibit a significant (FDR<0.05) association with SLE, both confirming some genes that have earlier been found to be associated with SLE (PTPN22 and IRF5) and presenting novel findings of genes (KLRG1, interleukin-16, protein tyrosine phosphatase receptor type T, toll-like receptor (TLR)8 and CASP10), which have not been reported earlier. 19440200 2009
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.070 Biomarker group BEFREE Both TLR8 and TLR7 are functional candidate genes owing to their key roles as pathogen recognition receptors and, in the case of TLR7, overexpression has been associated directly with murine autoimmune disease. 19956107 2009
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.030 AlteredExpression disease BEFREE TLR-8 mRNA and protein expression were substantially up-regulated in CEC from inflamed mucosa from patients with ulcerative colitis (approximately 350-fold, p<0.01) and Crohn's disease (approximately 45-fold, p<0.05) compared to controls. 18985539 2009
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.030 GeneticVariation disease BEFREE Both "risk (H4)" and "protective (H1)" TLR8 haplotypes were observed associated with CD in females. 18942751 2009