Actinic keratosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Comparing uninvolved skin and untreated AK, we found significant differences in the expression of interleukin (IL)-6, hurpin, TLR7 and TLR8.
|
15606509 |
2004 |
Tumor Immunity
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Adoptive transfer of TLR8 ligand-stimulated Treg cells into tumor-bearing mice enhanced anti-tumor immunity.
|
16123302 |
2005 |
Diarrhea
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
After 3 days of illness onset, only TLR3 and TLR8 mRNA expressions were still significantly (P<0.05) increased in 59% (44/75) children with diarrhoea.
|
16734605 |
2006 |
Rotavirus Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
To understand virus and host interactions and host responses to rotavirus infection in children, we analysed by real-time polymerase chain reaction (PCR) the expression of mRNA for five Toll-like receptors (TLRs) (TLR2, TLR3, TLR4, TLR7 and TLR8) and four T helper (Th)1 and Th2 cytokines [interleukin (IL)-2, IL-12, interferon (IFN)-gamma and IL-4) in peripheral blood mononuclear cells (PBMC) of children with acute rotavirus diarrhoea.
|
16734605 |
2006 |
X-linked agammaglobulinemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Impaired Toll-like receptor 8-mediated IL-6 and TNF-alpha production in antigen-presenting cells from patients with X-linked agammaglobulinemia.
|
17090647 |
2007 |
Agammaglobulinemia
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Impaired Toll-like receptor 8-mediated IL-6 and TNF-alpha production in antigen-presenting cells from patients with X-linked agammaglobulinemia.
|
17090647 |
2007 |
Virus Diseases
|
0.030 |
Biomarker
|
group |
BEFREE |
Lack of functioning Btk in XLA patients downstream of TLR8 and TLR9 might explain the susceptibility of XLA patients to viral infections.
|
17932028 |
2007 |
X-linked agammaglobulinemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Lack of functioning Btk in XLA patients downstream of TLR8 and TLR9 might explain the susceptibility of XLA patients to viral infections.
|
17932028 |
2007 |
Virus Diseases
|
0.030 |
Biomarker
|
group |
BEFREE |
These experiments of nature suggest that the TLR7-, TLR8-, and TLR9-dependent induction of IFN-alpha, IFN-beta, and IFN-lambda is largely redundant in human antiviral immunity, whereas the TLR3-dependent induction of IFN-alpha, IFN-beta, and IFN-lambda is critical for primary immunity to HSV-1 in the central nervous system in children but redundant for immunity to most other viral infections.
|
17979850 |
2007 |
Prostatic Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Our study shows that like CD4(+)CD25(+) Treg cells, CD8(+) Foxp3(+) Treg cells present in prostate tumor-derived TILs suppress immune responses and that their suppressive function can be regulated by TLR8 ligands, raising the possibility that the manipulation of Treg cell function by TLR8 ligands could improve the efficacy of immunotherapy for prostate cancer patients.
|
18056169 |
2007 |
Malignant neoplasm of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study shows that like CD4(+)CD25(+) Treg cells, CD8(+) Foxp3(+) Treg cells present in prostate tumor-derived TILs suppress immune responses and that their suppressive function can be regulated by TLR8 ligands, raising the possibility that the manipulation of Treg cell function by TLR8 ligands could improve the efficacy of immunotherapy for prostate cancer patients.
|
18056169 |
2007 |
Prostate carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study shows that like CD4(+)CD25(+) Treg cells, CD8(+) Foxp3(+) Treg cells present in prostate tumor-derived TILs suppress immune responses and that their suppressive function can be regulated by TLR8 ligands, raising the possibility that the manipulation of Treg cell function by TLR8 ligands could improve the efficacy of immunotherapy for prostate cancer patients.
|
18056169 |
2007 |
Virus Diseases
|
0.030 |
GeneticVariation
|
group |
LHGDN |
This first report of a functional TLR8 variant associated with a different clinical course of an RNA viral disease may have implications for the individual risk assessment of patients infected with HIV and other RNA viruses as well as for future HIV vaccine development.
|
18605904 |
2008 |
Human immunodeficiency virus (HIV) II infection category B1
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
This first report of a functional TLR8 variant associated with a different clinical course of an RNA viral disease may have implications for the individual risk assessment of patients infected with HIV and other RNA viruses as well as for future HIV vaccine development.
|
18605904 |
2008 |
HIV Infections
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Presently, very little is known about the influence of TLR8 genetic variation on susceptibility to and progression of HIV disease.
|
18605904 |
2008 |
Asthma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The most significant association was seen for rs2407992 (TLR8) in asthma (p = 0.00023, sample A and B combined, recessive model).
|
18682521 |
2008 |
Asthma
|
0.020 |
GeneticVariation
|
disease |
LHGDN |
The most significant association was seen for rs2407992 (TLR8) in asthma (p = 0.00023, sample A and B combined, recessive model).
|
18682521 |
2008 |
Atopic disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
By genome scanning, evidence of linkage between chromosome Xp22 and asthma and related atopic disorders has previously been obtained.Xp22 harbours the TLR7 and TLR8 genes.
|
18682521 |
2008 |
Tuberculosis, Pulmonary
|
0.090 |
Biomarker
|
disease |
BEFREE |
Taken together, our results provide evidence, for the first time, of a role for the TLR8 gene in susceptibility to pulmonary TB across different populations.
|
18927625 |
2008 |
Tuberculosis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We found that four polymorphisms in the TLR8 gene on chromosome X showed evidence of association with TB susceptibility in males, including a non-synonymous polymorphism rs3764880 (Met1Val; P = 0.007, odds ratio (OR) = 1.8, 95% c.i.= 1.2-2.7).
|
18927625 |
2008 |
Crohn Disease
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Both "risk (H4)" and "protective (H1)" TLR8 haplotypes were observed associated with CD in females.
|
18942751 |
2009 |
Inflammatory Bowel Diseases
|
0.020 |
GeneticVariation
|
group |
BEFREE |
The aim was to test whether TLR8 haplotypes are associated with IBD.
|
18942751 |
2009 |
Coronary Arteriosclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Toll-like receptor 8 polymorphism and coronary artery disease.
|
18985439 |
2009 |
Coronary heart disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Toll-like receptor 8 polymorphism and coronary artery disease.
|
18985439 |
2009 |
Coronary Artery Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether TLR8 Met1Val and TLR8-129G>C single nucleotide polymorphisms (SNPs rs3764879 and rs3764880) are associated with CAD in the Chinese population.
|
18985439 |
2009 |