|
Actinic keratosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Comparing uninvolved skin and untreated AK, we found significant differences in the expression of interleukin (IL)-6, hurpin, TLR7 and TLR8.
|
15606509 |
2004 |
|
Active tuberculosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The A-allele of TLR8 rs3764880 SNP was protective against the development of TB in males (A vs G, OR = 0.58, 95%CI = 0.37-0.91).
|
30424735 |
2018 |
|
Acute HIV infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
Drugs targeting macrophage TLR8-linked signaling pathways may modulate the innate immune response to acute HIV infection by reducing viral replication.
|
22393042 |
2012 |
|
Agammaglobulinemia
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Impaired Toll-like receptor 8-mediated IL-6 and TNF-alpha production in antigen-presenting cells from patients with X-linked agammaglobulinemia.
|
17090647 |
2007 |
|
Allergic rhinitis (disorder)
|
0.030 |
Biomarker
|
disease |
BEFREE |
Seven previously AR-associated SNPs from TLR8 were analyzed for AR associations in 422 AR patients and 859 controls from the BAMSE cohort.
|
26556310 |
2016 |
|
Allergic rhinitis (disorder)
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The first association analysis identified 4 allergic rhinitis-associated SNPs in the TLR7-TLR8 gene region.
|
22857391 |
2012 |
|
Allergic rhinitis (disorder)
|
0.030 |
Biomarker
|
disease |
BEFREE |
It will use a freely-existing application for AR monitoring that has been tested in 23 countries (the <i>Allergy Diary</i>, iOS and Android, 17,000 users, TLR8).
|
30237869 |
2018 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Data herein indicating that proinflammatory cytokines are reduced, whereas IFN-λ production and TLR8 and 9 MFI are augmented in those aMCI in whom AD conversion is not observed suggest that the ability to mount stronger antiviral response within an antiiflammatory milieu associates with lack of AD conversion.
|
29196629 |
2017 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We hypothesized that specific TLR members (TLR2, TLR3, TLR4, TLR8) may play a role in atherosclerosis progression and its accompanying inflammatory response.
|
28478461 |
2017 |
|
Arthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
A pathogenic role for TLR8 in human diseases was suggested by its increased expression in patients with systemic arthritis and the correlation of TLR8 expression with the elevation of IL-1β levels and disease status.
|
24277153 |
2013 |
|
Asthma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
These observations could not be attributed to alterations in the numbers of dendritic cell (DC) subsets in asthma or baseline expression of the viral RNA sensing receptors TLR7/TLR8.
|
25203745 |
2014 |
|
Asthma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The most significant association was seen for rs2407992 (TLR8) in asthma (p = 0.00023, sample A and B combined, recessive model).
|
18682521 |
2008 |
|
Asthma
|
0.020 |
GeneticVariation
|
disease |
LHGDN |
The most significant association was seen for rs2407992 (TLR8) in asthma (p = 0.00023, sample A and B combined, recessive model).
|
18682521 |
2008 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We hypothesized that specific TLR members (TLR2, TLR3, TLR4, TLR8) may play a role in atherosclerosis progression and its accompanying inflammatory response.
|
28478461 |
2017 |
|
Atopic disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
By genome scanning, evidence of linkage between chromosome Xp22 and asthma and related atopic disorders has previously been obtained.Xp22 harbours the TLR7 and TLR8 genes.
|
18682521 |
2008 |
|
Autoimmune Diseases
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Altogether, data uncover novel effects that type I IFN exerts in TLR8-activated neutrophils, which therefore enlarge our knowledge on the various biological actions which type I IFN orchestrates during infectious and autoimmune diseases.
|
26790609 |
2016 |
|
Autoimmune Diseases
|
0.070 |
Biomarker
|
group |
BEFREE |
We found that the consequence of self-recognition via TLR8 results in a constellation of diseases, strikingly distinct from those related to TLR7 signaling, and points to specific inflammatory diseases that may benefit from inhibition of TLR8 in humans.
|
24277153 |
2013 |
|
Autoimmune Diseases
|
0.070 |
Biomarker
|
group |
BEFREE |
Here, we report the implication of TLR7 signaling in high fat diet (HFD)-induced metabolic syndrome and exacerbation of lupus autoimmunity in TLR8-deficient (TLR8ko) mice, which develop spontaneous lupus-like disease due to increased TLR7 signaling by dendritic cells (DCs).
|
31552019 |
2019 |
|
Autoimmune Diseases
|
0.070 |
Biomarker
|
group |
BEFREE |
Given the role of TLR8 in autoimmunity, we also optimized the potency of <b>2</b> and developed a new TLR8 inhibitor bearing a 1,3,4-oxadiazole motif.
|
31687820 |
2019 |
|
Autoimmune Diseases
|
0.070 |
Biomarker
|
group |
BEFREE |
Both TLR8 and TLR7 are functional candidate genes owing to their key roles as pathogen recognition receptors and, in the case of TLR7, overexpression has been associated directly with murine autoimmune disease.
|
19956107 |
2009 |
|
Autoimmune Diseases
|
0.070 |
Biomarker
|
group |
BEFREE |
A variety of biological evaluations in cultured cell lines, human peripheral blood mononuclear cells, and splenocytes from human TLR8-transgenic mice further demonstrated these TLR8 inhibitors' high efficacy, suggesting strong therapeutic potential against autoimmune disorders.
|
30100350 |
2018 |
|
Autoimmune Diseases
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Illness may be caused by constitutive activation of human TLR7 or TLR8 in the bacterial artificial chromosome positive mice as increased TLR7 and TLR8 expression or activation has previously been implicated in autoimmune disease.
|
25229618 |
2014 |
|
Behcet Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of haplotypes of the TLR8 locus with susceptibility to Crohn's and Behçet's diseases.
|
26486764 |
2016 |
|
Biliary Atresia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
TLR8 mRNA, encoding the receptor for single-stranded RNA, was significantly higher in the early BA group, compared with non-BA groups (P = 0.008).
|
21832949 |
2011 |
|
Breast Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
It was observed that, in addition to TLR6, TLR7 and TLR8, the expression of the remaining TLRs in breast cancer tissues was lower than that in normal tissues.
|
31789409 |
2020 |