|
Respiratory Distress Syndrome, Adult
|
0.010 |
Biomarker
|
disease |
BEFREE |
In humans with Acute Respiratory Distress Syndrome (ARDS), we describe a potential role for TLR8 activation by circulating RNA ligands, as plasma and extracted RNA fractions from ARDS subjects activated TLR8 in vitro.
|
31385713 |
2020 |
|
Influenza A
|
0.010 |
Biomarker
|
disease |
BEFREE |
The TCR-independent methods include direct stimulation with the recombinant cytokines IL-12 and IL-18, and indirect stimulation with TLR-4/TLR-8 agonists or influenza A virus in the presence of APCs.
|
31792818 |
2020 |
|
Coxsackievirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
TLR8, an endosomal receptor, can recognize single-stranded RNA viruses, such as influenza virus, Sendai virus, Coxsackie B virus, HIV, and HCV.
|
31526944 |
2019 |
|
Influenza
|
0.010 |
Biomarker
|
disease |
BEFREE |
TLR8, an endosomal receptor, can recognize single-stranded RNA viruses, such as influenza virus, Sendai virus, Coxsackie B virus, HIV, and HCV.
|
31526944 |
2019 |
|
Malaria
|
0.010 |
Biomarker
|
disease |
BEFREE |
Altogether, our data are the first reported activation of TLR8 by protozoan RNA and demonstrate both the critical role of TLR8 in human blood-stage malaria and its unique functionality in the human immune system.
|
30972055 |
2019 |
|
Periodontitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In male participants, reduced susceptibility to periodontitis was observed in carriers of TLR7-rs3853839 (CC versus GG and CG, P = 0.02, OR 0.30, 95% CI 0.11-0.85) and TLR8-rs3764879 (CC versus GG and CG, P = 0.02, OR 0.31, 95% CI 0.12-0.82).
|
30517775 |
2019 |
|
Pneumonia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We here used a recently developed chemical antagonist of TLR8 to determine its role in human primary monocytes challenged with <i>S. aureus</i>, GBS, <i>Streptococcus pneumonia, Pseudomonas aeruginosa</i>, and <i>E. coli</i>.
|
31214180 |
2019 |
|
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
0.010 |
Biomarker
|
disease |
BEFREE |
We conclude that p53 can strongly influence TLR8-mediated immune responses and that knowledge of the p53-responsive SNP can inform diagnosis and prognosis of RSV disease and other diseases that might have a TLR8 component, including cancer.
|
31430261 |
2019 |
|
Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we found that <i>Il1f6</i><sup>-/-</sup> mice developed milder psoriasiform dermatitis upon treatment with imiquimod, a ligand for TLR ligand 7 (TLR7) and TLR8, whereas <i>Il1f6</i><sup>-/-</sup> mice showed similar susceptibility to dextran sodium sulfate-induced colitis to wild-type mice.
|
29794016 |
2018 |
|
Chronic Obstructive Airway Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Association of HJURP, MCRS1 and TLR8 are novel in relation to COPD.
|
29871630 |
2018 |
|
Meconium Aspiration Syndrome
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Compared with controls, TLR1 and TLR4 were highly expressed, TLR9 was moderately expressed, TLR7 was weakly expressed and TLR8 expression was neutral in neonates with MAS.
|
29095429 |
2018 |
|
Active tuberculosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The A-allele of TLR8 rs3764880 SNP was protective against the development of TB in males (A vs G, OR = 0.58, 95%CI = 0.37-0.91).
|
30424735 |
2018 |
|
Psoriasiform eczema
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we found that <i>Il1f6</i><sup>-/-</sup> mice developed milder psoriasiform dermatitis upon treatment with imiquimod, a ligand for TLR ligand 7 (TLR7) and TLR8, whereas <i>Il1f6</i><sup>-/-</sup> mice showed similar susceptibility to dextran sodium sulfate-induced colitis to wild-type mice.
|
29794016 |
2018 |
|
Malignant Head and Neck Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Phase Ib Study of Immune Biomarker Modulation with Neoadjuvant Cetuximab and TLR8 Stimulation in Head and Neck Cancer to Overcome Suppressive Myeloid Signals.
|
29061643 |
2018 |
|
Cervical intraepithelial neoplasia grade 2
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Six women with CIN2 regression, who presented with an HR-HPV DNA-negative CIN2 lesion at study entry, had significantly higher baseline levels of TLR2 (p = 0.005), TLR7 (p = 0.013) and TLR8 (p = 0.012), compared to women with CIN2 persistence/progression, suggesting their role in clearance of HPV prior to clearance of the lesion.
|
30121951 |
2018 |
|
Idiopathic Inflammatory Myopathies
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Toll-like receptor 7 (TLR-7), TLR-8, and interferon (IFN)-induced genes are expressed in patients with idiopathic inflammatory myositis.
|
29569859 |
2018 |
|
Pseudohyperkalemia Cardiff
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Carriage of the C allele in three SNPs of TLR3 (rs3775290, rs3775291, and rs5743312), the C allele in TLR7 (rs3853839) in females only, and the C allele in TLR8 (rs3764879) in males only were significantly higher in SVC group than CHC group (P < 0.001), while carriage of the T allele in TLR7 (rs179008) in females only and the A allele in TLR8 (rs3764880) in both males and females were significantly higher in CHC infection more than SVC group (P < 0.001).
|
29947302 |
2018 |
|
Head and Neck Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Phase Ib Study of Immune Biomarker Modulation with Neoadjuvant Cetuximab and TLR8 Stimulation in Head and Neck Cancer to Overcome Suppressive Myeloid Signals.
|
29061643 |
2018 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Data herein indicating that proinflammatory cytokines are reduced, whereas IFN-λ production and TLR8 and 9 MFI are augmented in those aMCI in whom AD conversion is not observed suggest that the ability to mount stronger antiviral response within an antiiflammatory milieu associates with lack of AD conversion.
|
29196629 |
2017 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We hypothesized that specific TLR members (TLR2, TLR3, TLR4, TLR8) may play a role in atherosclerosis progression and its accompanying inflammatory response.
|
28478461 |
2017 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We hypothesized that specific TLR members (TLR2, TLR3, TLR4, TLR8) may play a role in atherosclerosis progression and its accompanying inflammatory response.
|
28478461 |
2017 |
|
Hand, Foot and Mouth Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results of our study seem to indicate that the high expression levels of TLR3, TLR4, TLR7 and TLR8 induced in severe EV71 HFMD regulate the expression of cytokines by MAPK signaling pathway and negatively affect the ability of the organism to resolve the infection.
|
28565836 |
2017 |
|
melanoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High gene expression of TLR7 and TLR8 in melanoma tumors is associated with high expression levels of functional markers of immune cells, which predicts longer overall survival of patients with melanoma.
|
28919783 |
2017 |
|
Obesity
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data shows a positive feedback loop between blood monocytes and obese omental AT, which releases chemotactic mediators and TLR8-enriched MP, thus inducing an up-regulation of CD16<sup>+</sup> monocytes, favoring leukocyte infiltration in the obese omental AT.
|
27677832 |
2017 |
|
Skin lesion
|
0.010 |
Biomarker
|
group |
BEFREE |
These results indicate that paeonol suppresses the maturation and activation of DCs by decreasing MyD88 and TLR8 proteins in the TLR7/8 signaling pathway which finally alleviates psoriasis‑like skin lesions.
|
28339016 |
2017 |