|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
The female-specific association between RELN and schizophrenia is one of the few examples of a replicated sex-specific genetic association in any disease.
|
18282107 |
2008 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
The DNA methylation status of the promoter region of RELN was examined by using the pyrosequencing method in the prefrontal cortices of 14 patients with schizophrenia and 13 control subjects.
|
17870056 |
2008 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
The female-specific association between RELN and schizophrenia is one of the few examples of a replicated sex-specific genetic association in any disease.
|
18282107 |
2008 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We began with 14 genes that are relevant to schizophrenia, based on association studies or their role in neurodevelopment, and then used statistical techniques to reduce them to five genes and 17 single nucleotide polymorphisms (SNPs) that had a significant statistical interaction: five for PDE4B, four for RELN, four for ERBB4, three for DISC1 and one for NRG1.
|
21876540 |
2012 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in RELN have been implicated in related disorders like autism and schizophrenia but have not been examined in dyslexia.
|
30199849 |
2018 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The DNA methylation status of the promoter region of RELN was examined by using the pyrosequencing method in the prefrontal cortices of 14 patients with schizophrenia and 13 control subjects.
|
17870056 |
2008 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
The female-specific association between RELN and schizophrenia is one of the few examples of a replicated sex-specific genetic association in any disease.
|
18282107 |
2008 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We evaluated whether an RELN gene variant, rs362719, which has been associated with increased susceptibility to bipolar disorder, is also associated with susceptibility to schizophrenia.
|
21863557 |
2011 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This study does not suggest a significant impact of rs7341475 on brain structure, function, and RELN expression, arguing that this single nucleotide polymorphism and others linked with it do not affect brain measures related to the biology of schizophrenia.
|
20434133 |
2010 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Human genetic studies suggest that rare RELN variants confer susceptibility to mental disorders such as schizophrenia.
|
30022058 |
2018 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We found that RELN rs736707 was significantly related with psychiatric disorders (schizophrenia, autism spectrum disorders and attention-deficit hyperactivity disorder) in Asian group (C vs T, OR=1.26, 95% CI=1.13-1.41, P<0.01, FDR<0.01), and rs7341475 was only significantly associated with reduced risk of schizophrenia in Caucasian (A vs G, OR=0.88, 95% CI=0.82-0.95, P<0.01, FDR<0.01).
|
28506622 |
2017 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Identification of a single nucleotide polymorphism at the 5' promoter region of human reelin gene and association study with schizophrenia.
|
12082559 |
2002 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our results revealed that, along with the RELN deletion, neuronal death was promoted in this patient; thus, neuronal death may be a vulnerable factor for schizophrenia.
|
31848032 |
2019 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Replication of an association of a common variant in the Reelin gene (RELN) with schizophrenia in Ashkenazi Jewish women.
|
20431428 |
2010 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We found no significant association of schizophrenia with the trinucleotide repeat polymorphism of the reelin or VLDLR genes, suggesting that these polymorphisms do not have a major role in the pathogenesis of the disease.
|
12363388 |
2002 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that allelic variants of RELN contribute to the endophenotypes of schizophrenia.
|
17684500 |
2008 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Our results weakly support an association of reelin gene variants with schizophrenia as a whole, yet suggest that reelin could be associated with treatment-resistant schizophrenia.
|
15965968 |
2005 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Our findings suggest that allelic variants of RELN contribute to the endophenotypes of schizophrenia.
|
17684500 |
2008 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our findings do not support the involvement of the polymorphic GGC triplets of the reelin gene in the pathogenesis of schizophrenia in the population studied.
|
16556465 |
2006 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our results weakly support an association of reelin gene variants with schizophrenia as a whole, yet suggest that reelin could be associated with treatment-resistant schizophrenia.
|
15965968 |
2005 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
There was no statistically significant association between the rs7341475 variant of RELN gene and schizophrenia in the overall population (χ<sup>2</sup> = 2.473, p = 0.290).
|
30980267 |
2019 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Variants in the genes coding for dopamine-D2 receptor, brain-derived neurotrophic factor (BDNF), neuropeptide Y (NPY), neuregulin 1, reelin and synapsin 3 showed association with schizophrenia, although few subjects were found in the minority allele for the two latter variants.
|
17366345 |
2007 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggests that rs7341475 (A/G) and rs262355 (A/T) polymorphisms in RELN gene are inversely associated with SZ risk.
|
26455866 |
2015 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
IN-derived Reelin has been associated with schizophrenia and temporal lobe epilepsy; however, the functional role of Reelin from INs is presently unclear.
|
31667489 |
2019 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our findings demonstrate that RELN is a susceptibility gene for schizophrenia in Chinese population, and it is likely a common risk gene for schizophrenia in major populations worldwide.
|
21745129 |
2013 |