|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Schizophrenia (SZ) and bipolar disorder (BPD) patients show a downregulation of GAD67, reelin (RELN), brain-derived neurotrophic factor (BDNF), and other genes expressed in telencephalic GABAergic and glutamatergic neurons.
|
25364290 |
2014 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Schizophrenia and reelin: a model based on prenatal stress to study epigenetics, brain development and behavior.
|
26968981 |
2016 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Reelin mRNA showed a trend reduction in the subjects with schizophrenia (-26%; P=0.07) and, notably, was negatively correlated with sema3A.
|
12610647 |
2003 |
|
Schizophrenia
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
Reelin promoter hypermethylation in schizophrenia.
|
15961543 |
2005 |
|
Schizophrenia
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
Reelin promoter hypermethylation in schizophrenia.
|
16574235 |
2006 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Reelin (RELN) is identified as a risk gene for major psychiatric disorders such as schizophrenia (SCZ) and bipolar disorder (BPD).
|
26637325 |
2016 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Reelin is decreased in the postmortem brain in schizophrenia patients.
|
28583708 |
2020 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
A down-regulation of reelin and glutamic acid decarboxylase (GAD) 67 mRNAs was detected in gamma-aminobutyric acid (GABA)ergic cortical interneurons of schizophrenia (SZ) postmortem brains (10), suggesting that the availability of GABA and reelin may be decreased in SZ cortex.
|
14684836 |
2004 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
A protein putatively functioning as an intracellular target for the signal-transduction cascade triggered by RELN protein released into the extracellular matrix is termed mouse disabled-1 (DAB1) and is expressed at comparable levels in the neuroplasm of the PFC and hippocampal pyramidal neurons, cerebellar Purkinje neurons of schizophrenia patients, and nonpsychiatric subjects; these three types of neurons do not express RELN protein.
|
9861036 |
1998 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
An understanding of the epigenetic regulation of reelin gene expression and of the possible pathogenetic role of reelin deficiency in schizophrenia, may become a major focus that will open new avenues for the treatment of this disease.
|
11786309 |
2002 |
|
Schizophrenia
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
Based upon the assumption of parallel methylation changes in the brain and peripheral blood, we concluded that RELN DNA methylation might contribute to the pathogenesis of schizophrenia.
|
28086126 |
2017 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Besides LIS2 and ADLTE, <i>RELN</i> and/or other genes coding for the proteins of the Reln intracellular cascade have been associated substantially to other conditions such as spinocerebellar ataxia type 7 and 37, <i>VLDLR</i>-associated cerebellar hypoplasia, <i>PAFAH1B1</i>-associated lissencephaly, autism, and schizophrenia.
|
31805691 |
2019 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
CRMP1 is a novel candidate protein for schizophrenia traits at the intersection of the reelin and DISC1 pathways that directly and functionally interacts with DISC1.
|
22798627 |
2012 |
|
Schizophrenia
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
Despite the small sample size, these studies indicate that promoter hypermethylation of the RELN gene could be a significant contributor in effecting epigenetic alterations and provides a molecular basis for the RELN gene hypoactivity in schizophrenia.
|
15717292 |
2005 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Eight markers obtained nominal significance in both tests, and were located in intronic or 3'UTR regions of adhesion molecule MDGA1 and previously reported SZ candidate RELN.
|
18384059 |
2008 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Excessive RELN promoter methylation and/or decreased RELN gene expression have been described in schizophrenia and autism.
|
19952965 |
2010 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Human genetic studies suggest that rare RELN variants confer susceptibility to mental disorders such as schizophrenia.
|
30022058 |
2018 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Identification of a single nucleotide polymorphism at the 5' promoter region of human reelin gene and association study with schizophrenia.
|
12082559 |
2002 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
CTD_human |
In addition, reelin protein in the molecular layer of the dentate gyrus was decreased in schizophrenia, bipolar disorder, and depression at the trend level of statistical significance (P=0.065).
|
14708030 |
2004 |
|
Schizophrenia
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
In our present study we investigated methylation of genomic DNA and promoter methylation of Reelin and SOX10 genes in peripheral blood of twins suffering from schizophrenia.
|
23102571 |
2012 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
In summary, the reelin haploinsufficient mouse may provide a useful model for studying the interaction between reelin and hippocampal GABAergic system, its effect on dendritic spine maturation and plasticity related to schizophrenia.
|
21226776 |
2011 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In the same samples, the GABAergic neuron-specific glutamic acid-decarboxylase(67) (GAD(67)) and reelin mRNAs were underexpressed twofold in GABAergic interneurons isolated from layer I of SZP relative to GABAergic interneurons microdissected from layer I of NPS, and unaltered in GABAergic interneurons of layer V. These findings implicate an epigenetically mediated layer I GABAergic dysfunction in the pathogenesis of schizophrenia, and suggest novel strategies for treatment of the disease.
|
17264840 |
2007 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
In this study, case-control association analyses were performed in the Han Chinese population to determine if the RELN gene is a susceptibility gene for SZ.
|
21549172 |
2011 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
IN-derived Reelin has been associated with schizophrenia and temporal lobe epilepsy; however, the functional role of Reelin from INs is presently unclear.
|
31667489 |
2019 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Interstitial white matter neurons, presumed remnants of the cortical subplate, contribute to the reduction in reelin mRNA in schizophrenia.
|
16513881 |
2006 |