|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
A protein putatively functioning as an intracellular target for the signal-transduction cascade triggered by RELN protein released into the extracellular matrix is termed mouse disabled-1 (DAB1) and is expressed at comparable levels in the neuroplasm of the PFC and hippocampal pyramidal neurons, cerebellar Purkinje neurons of schizophrenia patients, and nonpsychiatric subjects; these three types of neurons do not express RELN protein.
|
9861036 |
1998 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
CTD_human |
We present new immunocytochemical evidence showing reductions in Reelin expression in hippocampus of subjects with schizophrenia, bipolar disorder and major depression and confirm recent reports documenting a similar deficit involving Reelin expression in brains of subjects with schizophrenia and bipolar disorder.
|
11126396 |
2000 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
This hypothesis is supported by a genetic mouse model of reelin haploinsufficiency that replicates the above-described dendritic and presynaptic GABAergic defects documented in schizophrenia brains.
|
11592844 |
2001 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Identification of a single nucleotide polymorphism at the 5' promoter region of human reelin gene and association study with schizophrenia.
|
12082559 |
2002 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
MGD |
Preferential alterations in the mesolimbic dopamine pathway of heterozygous reeler mice: an emerging animal-based model of schizophrenia.
|
11982630 |
2002 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We found no significant association of schizophrenia with the trinucleotide repeat polymorphism of the reelin or VLDLR genes, suggesting that these polymorphisms do not have a major role in the pathogenesis of the disease.
|
12363388 |
2002 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
An understanding of the epigenetic regulation of reelin gene expression and of the possible pathogenetic role of reelin deficiency in schizophrenia, may become a major focus that will open new avenues for the treatment of this disease.
|
11786309 |
2002 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Superficial IWMNs (P=0.008) and layer I neurons (P=0.036) both expressed less reelin mRNA per cell in schizophrenia, with a trend for deep IWMNs (P=0.055).
|
12931209 |
2003 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
LHGDN |
Superficial IWMNs (P=0.008) and layer I neurons (P=0.036) both expressed less reelin mRNA per cell in schizophrenia, with a trend for deep IWMNs (P=0.055).
|
12931209 |
2003 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Reelin mRNA showed a trend reduction in the subjects with schizophrenia (-26%; P=0.07) and, notably, was negatively correlated with sema3A.
|
12610647 |
2003 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
A down-regulation of reelin and glutamic acid decarboxylase (GAD) 67 mRNAs was detected in gamma-aminobutyric acid (GABA)ergic cortical interneurons of schizophrenia (SZ) postmortem brains (10), suggesting that the availability of GABA and reelin may be decreased in SZ cortex.
|
14684836 |
2004 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
CTD_human |
In addition, reelin protein in the molecular layer of the dentate gyrus was decreased in schizophrenia, bipolar disorder, and depression at the trend level of statistical significance (P=0.065).
|
14708030 |
2004 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
This gene's protein Reelin, which is necessary for neuronal migration and synaptogenesis, is reduced in schizophrenia and bipolar disorder, suggesting hypermethylation of the promoter region in these disorders.
|
15108180 |
2004 |
|
Schizophrenia
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
Despite the small sample size, these studies indicate that promoter hypermethylation of the RELN gene could be a significant contributor in effecting epigenetic alterations and provides a molecular basis for the RELN gene hypoactivity in schizophrenia.
|
15717292 |
2005 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Such downregulation suggests that the neuropil hypoplasticity found in the PFC of SZ and BP disorder patients may depend on a downregulation of GABAergic function, which is associated with a decrease in reelin secretion from GABAergic neuron axon terminals on dendrites, somata, or axon initial segments of pyramidal neurons.
|
15864560 |
2005 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
CTD_human |
We employed SDS-PAGE and Western blotting to measure levels of GAD isomers 65 and 67 kDa and Reelin isoforms 410-, 330- and 180-kDa proteins as well as beta-actin in cerebellum of subjects with schizophrenia, bipolar disorder and major depression vs. controls (N = 15 per group).
|
15560956 |
2005 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
These data support the hypothesis that the reduced amounts of reelin and GAD67 mRNAs documented in postmortem schizophrenia brain may be the consequence of a Dnmt1-mediated hypermethylation of the corresponding promoters.
|
15671176 |
2005 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Our results weakly support an association of reelin gene variants with schizophrenia as a whole, yet suggest that reelin could be associated with treatment-resistant schizophrenia.
|
15965968 |
2005 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
LHGDN |
We have analyzed the extent and pattern of methylation within the CpG island of the reelin promoter in genomic DNA isolated from cortices of schizophrenia patients and nonpsychiatric subjects.
|
15961543 |
2005 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our results weakly support an association of reelin gene variants with schizophrenia as a whole, yet suggest that reelin could be associated with treatment-resistant schizophrenia.
|
15965968 |
2005 |
|
Schizophrenia
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
Reelin promoter hypermethylation in schizophrenia.
|
15961543 |
2005 |
|
Schizophrenia
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
Reelin promoter hypermethylation in schizophrenia.
|
16574235 |
2006 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Interstitial white matter neurons, presumed remnants of the cortical subplate, contribute to the reduction in reelin mRNA in schizophrenia.
|
16513881 |
2006 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Reduced levels of Reelin are also present in postmortem brains of patients with schizophrenia, suggesting a possible link with this cognitive disorder.
|
16266828 |
2006 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our findings do not support the involvement of the polymorphic GGC triplets of the reelin gene in the pathogenesis of schizophrenia in the population studied.
|
16556465 |
2006 |