|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
IN-derived Reelin has been associated with schizophrenia and temporal lobe epilepsy; however, the functional role of Reelin from INs is presently unclear.
|
31667489 |
2019 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Our findings demonstrate that RELN is a susceptibility gene for schizophrenia in Chinese population, and it is likely a common risk gene for schizophrenia in major populations worldwide.
|
21745129 |
2013 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
The female-specific association between RELN and schizophrenia is one of the few examples of a replicated sex-specific genetic association in any disease.
|
18282107 |
2008 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
The DNA methylation status of the promoter region of RELN was examined by using the pyrosequencing method in the prefrontal cortices of 14 patients with schizophrenia and 13 control subjects.
|
17870056 |
2008 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Therefore, these results suggest that the reelin and GAD67 promoters are subject to continuous repression by DNA methyltransferase and that inhibitors of DNA methyltransferase represent a potential treatment for Schizophrenia.
|
17179443 |
2007 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
CTD_human |
This remodeling might contribute to reelin- and GAD(67)-promoter demethylation and might reverse the GABAergic-gene-expression downregulation associated with SZ morbidity.
|
19110320 |
2009 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
We report here, that the binding of DNMT1 to GABAergic (GAD1, RELN) and glutamatergic (BDNF-IX) promoters is increased in SZ and BP disorder patients and this increase does not necessarily correlate with enrichment in promoter methylation.
|
25476119 |
2015 |
|
Schizophrenia
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
Despite the small sample size, these studies indicate that promoter hypermethylation of the RELN gene could be a significant contributor in effecting epigenetic alterations and provides a molecular basis for the RELN gene hypoactivity in schizophrenia.
|
15717292 |
2005 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
The female-specific association between RELN and schizophrenia is one of the few examples of a replicated sex-specific genetic association in any disease.
|
18282107 |
2008 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
CRMP1 is a novel candidate protein for schizophrenia traits at the intersection of the reelin and DISC1 pathways that directly and functionally interacts with DISC1.
|
22798627 |
2012 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Superficial IWMNs (P=0.008) and layer I neurons (P=0.036) both expressed less reelin mRNA per cell in schizophrenia, with a trend for deep IWMNs (P=0.055).
|
12931209 |
2003 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
A protein putatively functioning as an intracellular target for the signal-transduction cascade triggered by RELN protein released into the extracellular matrix is termed mouse disabled-1 (DAB1) and is expressed at comparable levels in the neuroplasm of the PFC and hippocampal pyramidal neurons, cerebellar Purkinje neurons of schizophrenia patients, and nonpsychiatric subjects; these three types of neurons do not express RELN protein.
|
9861036 |
1998 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Reelin (RELN) is identified as a risk gene for major psychiatric disorders such as schizophrenia (SCZ) and bipolar disorder (BPD).
|
26637325 |
2016 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We began with 14 genes that are relevant to schizophrenia, based on association studies or their role in neurodevelopment, and then used statistical techniques to reduce them to five genes and 17 single nucleotide polymorphisms (SNPs) that had a significant statistical interaction: five for PDE4B, four for RELN, four for ERBB4, three for DISC1 and one for NRG1.
|
21876540 |
2012 |
|
Schizophrenia
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
Reelin promoter hypermethylation in schizophrenia.
|
16574235 |
2006 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
We also consider other risk-associated genes for schizophrenia such as dysbindin (DTNBP1), neuregulin (NRG1), disrupted-in-schizophrenia1 (DISC1), reelin and proline dehydrogenase (PRODH).
|
21557953 |
2012 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
This has implications for brain disorders, such as epilepsy and schizophrenia, in which deficiencies in Reelin expression occur.
|
20598379 |
2010 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Excessive RELN promoter methylation and/or decreased RELN gene expression have been described in schizophrenia and autism.
|
19952965 |
2010 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Such downregulation suggests that the neuropil hypoplasticity found in the PFC of SZ and BP disorder patients may depend on a downregulation of GABAergic function, which is associated with a decrease in reelin secretion from GABAergic neuron axon terminals on dendrites, somata, or axon initial segments of pyramidal neurons.
|
15864560 |
2005 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in RELN have been implicated in related disorders like autism and schizophrenia but have not been examined in dyslexia.
|
30199849 |
2018 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
A down-regulation of reelin and glutamic acid decarboxylase (GAD) 67 mRNAs was detected in gamma-aminobutyric acid (GABA)ergic cortical interneurons of schizophrenia (SZ) postmortem brains (10), suggesting that the availability of GABA and reelin may be decreased in SZ cortex.
|
14684836 |
2004 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The DNA methylation status of the promoter region of RELN was examined by using the pyrosequencing method in the prefrontal cortices of 14 patients with schizophrenia and 13 control subjects.
|
17870056 |
2008 |
|
Schizophrenia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
It has been suggested that reduced Reelin activity contributes to the pathogenesis of several neuropsychiatric and neurodegenerative disorders, such as schizophrenia and Alzheimer's disease; however, noninvasive methods that can upregulate Reelin activity <i>in vivo</i> have yet to be developed.
|
28213441 |
2017 |
|
Schizophrenia
|
0.700 |
Biomarker
|
disease |
BEFREE |
We thus propose a particular role for RELN as a modifier gene of the pathogenesis of schizophrenia.
|
19922905 |
2010 |
|
Schizophrenia
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
The female-specific association between RELN and schizophrenia is one of the few examples of a replicated sex-specific genetic association in any disease.
|
18282107 |
2008 |