|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our data provide supporting evidence of an association between the STin2 VNTR polymorphism of the SLC6A4 gene and OCD.
|
18191318 |
2008 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Haplotype-based testing of rs25532 and all other known non-coding functional SLC6A4 variants revealed a highly significant omnibus association with OCD in a large case-control sample.
|
18055562 |
2008 |
|
Obsessive-Compulsive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The purpose of the present study was to determine whether polymorphisms of the serotonin transporter (5-HTT), 5-HT1B, and 5-HT2A receptor genes affect the efficacy of SRI treatment in OCD.
|
17503984 |
2007 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Here, two different but related statistical techniques (multiple regression and partial least squares), confirmed that physical neglect and the 5-HTT genotype jointly play a role in predicting dissociation in OCD.
|
17943026 |
2007 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Subgroups based on the age of OCD onset, gender, familiality, factor analysis-derived symptom dimensions, or comorbidity with other psychiatric disorders failed to identify SLC6A4- or BDNF-associated phenotypes, with one exception of overall number of comorbid anxiety disorders being significantly associated with 5-HTTLPR/rs25531.
|
17375136 |
2007 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
By using random effects model, data from these studies were pooled to compare the genotypes and allelic distribution of the 5-HTTLPR polymorphism between OCD patients and control subjects.
|
17291658 |
2007 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder.
|
16642437 |
2006 |
|
Obsessive-Compulsive Disorder
|
0.600 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Variation of the serotonin transporter gene SLC6A4 in the susceptibility to migraine with aura.
|
17101915 |
2006 |
|
Obsessive-Compulsive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The goal of this study was to examine relationships between OCD symptom dimensions and 5-HTTLPR.
|
16583440 |
2006 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
However, taking in account OCD phenotypes, we found indication towards an association of the 5-HTTLPR S-allele with female OCD patients, and the 5-HT2A G-allele and GG genotype with patients with a positive family history of OCD and an early onset of disease.
|
16443280 |
2006 |
|
Obsessive-Compulsive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
We assessed whole blood serotonin (5-HT) concentration, platelet 5-HT transporter (5-HTT) and 5-HT2A receptor-binding characteristics, and platelet inositol trisphosphate (IP3) content in a sample of OCD probands (n = 48) and their unaffected parents (n = 65), and compared them with sex- and age-matched controls (n = 113).
|
15886722 |
2005 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Therefore, the aims of this study were to investigate the associations between 5-HT transporter polymorphism and OCD.
|
16220023 |
2005 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No association was detected between the 5-HTTLPR polymorphism and OCD in either the case control study or the family study.
|
15172105 |
2004 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this cross-sectional study, we have examined the allelic and genotypic frequencies of a Val-158-Met substitution in the COMT gene, a 44-base pair (bp) length variation in the regulatory region of the serotonin transporter gene (5-HTTLPR) and the T102C and C516T variants in the serotonin receptor type 2A (5HT2A) gene in 79 OCD patients and 202 control subjects.
|
15005715 |
2004 |
|
Obsessive-Compulsive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The serotonin transporter locus (SLC6A4) maps nearby and is considered a functional candidate gene in autism and obsessive-compulsive disorder.
|
15108191 |
2004 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No significant differences in allele/genotype distribution of the 5-HTTLPR were found between 191 controls and OCD.
|
12082589 |
2002 |
|
Obsessive-Compulsive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Since SSRIs act on the serotonin transporter (5-HTT), it has been suggested that the 5-HTT gene (SCL6A4) could be a good candidate for OCD.
|
11602033 |
2001 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This finding replicates a recent family-based study of this polymorphism in OCD, and thus indicates that the 5-HTTLPR may be associated with susceptibility to OCD.
|
10523819 |
1999 |
|
Obsessive-Compulsive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The human serotonin transporter (hSERT) gene is a promising candidate for mediating the genetic susceptibility for various psychiatric conditions such as mood and obsessive-compulsive disorders.
|
10089018 |
1999 |
|
Obsessive-Compulsive Disorder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These data provide preliminary support for association and linkage disequilibrium between the SLC6A4 'l' allele and OCD.
|
9672904 |
1998 |
|
Obsessive-Compulsive Disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The successful use of SRIs in OCD has led to the hypothesis that 5-HTT may play a pivotal role in the pathogenesis of OCD.
|
9322235 |
1997 |