|
Diabetes Mellitus, Insulin-Dependent
|
0.030 |
Biomarker
|
disease |
BEFREE |
Polymorphism of the genes encoding the alpha, beta, and gamma chains of the human T-cell receptor (TCRA, TCRB, and TCRG), insulin gene (INS), and three closely linked polymorphic genes on chromosome 11q23, Thy-1 (THY1), T3-D (CD3D), and c-ets proto oncogene (ETS1) were investigated among 56 unrelated patients with insulin-dependent diabetes mellitus (IDDM) and 48 healthy controls.
|
1982251 |
1991 |
|
Primary malignant neoplasm
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Dominant Variable (V) and Joining (J) gene pair rearrangements in cancer cells were confirmed by polymerase chain reaction (PCR) amplification and Sanger sequencing; clonality assessment of clinical isolates using BIOMED-2 methods showed agreement for 73% and 77% of samples at the β and γ loci, respectively, whereas β locus V and J allele prevalence in PBMCs were well correlated with results from commercial PCR-based DNA sequencing assays (<i>r</i><sup>2</sup> = 0.94 with Adaptive ImmunoSEQ, 0.77-0.83 with Invivoscribe LymphoTrack TRB Assay).
|
30530777 |
2018 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Shuffling the deck with CTLA-4 therapy: Deep sequencing of rearranged TCRB genes demonstrates T cell repertoire remodeling in cancer patients.
|
29632706 |
2018 |
|
Sezary Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
The lack of clear stereotypic TCRA and TCRB CDR3 amino acid motifs would argue against involvement of a single common antigen in the pathogenesis of SS.
|
21410672 |
2011 |
|
Lymphoma, T-Cell, Cutaneous
|
0.020 |
Biomarker
|
disease |
BEFREE |
We analyzed TCR gene loci (TCRAD, TCRB, and TCRG) status in CTCLs by fluorescence in situ hybridization (FISH).
|
21872828 |
2011 |
|
Leukemia, T-Cell
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Strikingly, profiling of the T-ALLs by clinical, genomic, and large-scale gene expression analyses shows that the TCRB-MYB translocation defines a new T-ALL subtype associated with a very young age for T-cell leukemia (median, 2.2 years) and with a proliferation/mitosis expression signature.
|
17452517 |
2007 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Strikingly, profiling of the T-ALLs by clinical, genomic, and large-scale gene expression analyses shows that the TCRB-MYB translocation defines a new T-ALL subtype associated with a very young age for T-cell leukemia (median, 2.2 years) and with a proliferation/mitosis expression signature.
|
17452517 |
2007 |
|
Sezary Syndrome
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We have examined in detail the features of the T-cell receptor beta (TCRB) gene rearrangements in 20 individuals with well-defined stages of cutaneous T-cell lymphoma (CTCL) comprising 10 cases with early-stage mycosis fungoides (MF) and 10 cases with late-stage MF or Sezary syndrome.
|
16741518 |
2006 |
|
Lymphoma, T-Cell, Cutaneous
|
0.020 |
Biomarker
|
disease |
BEFREE |
Although we found that TCRB gene usage in CTCL and normal individuals share common features, our analysis also revealed preferential usage of Jbeta1 genes in all cases with advanced stages of disease.
|
16741518 |
2006 |
|
Lymphoma, T-Cell, Cutaneous
|
0.020 |
Biomarker
|
disease |
LHGDN |
Although we found that TCRB gene usage in CTCL and normal individuals share common features, our analysis also revealed preferential usage of Jbeta1 genes in all cases with advanced stages of disease.
|
16741518 |
2006 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Simultaneous detection of TCRA/D or TCRB breaks was achieved in a multicolor approach, which was further combined with detection of the T-cell-specific CD3 antigen in a multicolor FICTION (Fluorescence Immunophenotyping and Interphase Cytogenetics as a Tool for the Investigation of Neoplasm) assay.
|
12682631 |
2003 |
|
Arthritis, Reactive
|
0.020 |
Biomarker
|
disease |
LHGDN |
All but one patient-derived conserved sequences originated from acute stage ReA-patients, and were not present among approximately 3800 other human TCRB sequences in the database.
|
12472659 |
2002 |
|
Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Genotypic analysis showed that the tumors were B-lineage and clonal, with rearrangements of the Ig heavy- and kappa light-chain loci and no rearrangements of the T-cell receptor beta locus.
|
9376569 |
1997 |
|
Arthritis, Reactive
|
0.020 |
Biomarker
|
disease |
BEFREE |
The authors, therefore, sequenced 25 TCRB chains from HLA-B27-restricted CD8+ CTL clones and two clonal lines specific for self- or Yersinia enterocolitica antigen isolated from synovial fluids of 3 HLA-B27+ patients with ReA and PBL of one healthy HLA-B27+ individual.
|
8560188 |
1996 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Molecular analysis of TCRB and ABL in a t(7;9)-containing cell line (SUP-T3) from a human T-cell leukemia.
|
3025859 |
1987 |
|
Cystic Fibrosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Genetic linkage has been analyzed between cystic fibrosis (CF) and a number of markers on the long arm of chromosome 7, including D7S15, COL1A2, PON, MET, D7S8, and TCRB, using a cohort of 47 Canadian and 13 Danish CF families.
|
3467587 |
1986 |
|
Cystic Fibrosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The linkage of cystic fibrosis (CF) and the polymorphic DNA markers pJ3.11, met, 7C22, DOCR1-917, COL1A2, and TCRB have jointly localized the mutation causing CF to chromosome 7q2.1-3.1.
|
3467586 |
1986 |
|
Leukemia, T-Cell
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In an attempt to more accurately define cell lineage we have analyzed cells from patients with B- or T-cell leukemia (n = 26) at various stages of maturation with probes to two additional TCR genes, TCRG and TCRA (encoding the TCR gamma and alpha chains, respectively), as well as the IG heavy chain joining region (IGHJ) and TCRB genes.
|
3464980 |
1986 |
|
Chronic Lymphocytic Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Thus, standardization of protocols in NGS immunogenetics is urgently needed.Here, we describe the experimental protocol that we developed for T-cell receptor beta chain (TRB) gene repertoire analysis in chronic lymphocytic leukemia, aiming to provide a reproducible and biologically meaningful output.
|
30350216 |
2019 |
|
Influenza A
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, multiplex PCR based on genomic DNA amplicons and Illumina high-throughput sequencing (HTS) were applied to study the characteristics and polymorphisms of the TRB and IGH repertoire in the peripheral blood mononuclear cells (PBMCs) from two H5N6 AIV patients and six healthy donors (NC).
|
31092835 |
2019 |
|
Degenerative polyarthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These results suggest the potential of TRB-N0224 to modulate MMP and cytokine levels, slowing the macroscopic and histopathological progression of OA.
|
30486657 |
2018 |
|
Hematologic Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We performed comprehensive next generation sequencing based genomic characterization of 11 cases of BIA-ALCL including sequence variant detection on 180 genes frequently mutated in haematological malignancy, genome-wide copy number assessment, structural variant detection involving the T-cell receptor loci and TRB deep-sequencing.
|
30546832 |
2018 |
|
T-Cell Prolymphocytic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We compared the results of parallel analyses of Vβ expression by FCM and TRB rearrangements by DNA-based next-generation sequencing (NGS) in 80 diagnostic peripheral blood samples of patients with T-cell prolymphocytic leukemia (T-PLL) for (1) the diagnosis of clonality and (2) the assessment of dominant Vβ usage.
|
30414304 |
2018 |
|
Hemophilia A
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
TCRB sequencing of clones and lines from the mild HA subjects also identified a limited TCRB gene repertoire.
|
27471234 |
2016 |
|
Lymphoma
|
0.010 |
GeneticVariation
|
group |
BEFREE |
In T-cell acute lymphoblastic leukemia/lymphoma (T-ALL/LBL), activating mutations of NOTCH1 are observed in more than 50% of cases, whereas the t(7;9)(q34;q34) involving NOTCH1 at 9q34 and TRB@ at 7q34 is an extremely rare but recurrent translocation.
|
23033986 |
2013 |