|
Obesity, Morbid
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Severe obesity is associated with suppressed expression of both ApN and its receptors in both SAT and VAT, the expression levels in VAT are specifically linked with hyperinsulinemia and dyslipidemia.
|
17607322 |
2007 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Obesity increases the expression of leptin and other cytokines, as well as some macrophage and inflammatory markers, and decreases adiponectin expression in adipose tissue.A number of cytokines, e.g. tumour necrosis factor alpha (TNF-alpha) and monocyte chemotactic protein 1 (MCP-1), and some pro-inflammatory interleukins, leuckocyte antigens, chemochines, surface adhesion molecules and metalloproteases are up-regulated whereas other factors are down-regulated.
|
17922949 |
2007 |
|
Obesity
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Obesity-related phenotype candidate genes include the gene encoding adiponectin (AdipoQ).
|
17992633 |
2007 |
|
Hyperinsulinism
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Insulin increased adiponectin expression specifically in the omental tissue (P = 0.011).
|
18208577 |
2008 |
|
Endocrine System Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Endocrine disorders in epicardial adipose tissue are strongly linked to CAD, and adiponectin has a protective effect by inhibiting macrophage-mediated inflammation.
|
21226932 |
2011 |
|
Hypoadiponectinemia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Hypoadiponectinemia was defined as the lowest quartile of adiponectin.
|
21617638 |
2012 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Obesity is associated with circulating levels of adiponectin and leptin and endometrial cancer risk.
|
22038736 |
2012 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Obesity is a well-established risk factor for endometrial cancer, due in part to the adipokines generated by adipose tissue, such as adiponectin (also known as Acrp30) and leptin, which are associated with many endocrine-related cancers.
|
22327423 |
2012 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Obesity is per se associated with increased adipose expression and plasma levels of leptin, lower expression of adiponectin, and marginally elevated expression of IL-6, but PCOS does not appear to have an independent effect on the adipose expression of leptin, adiponectin, and IL-6 or the circulating adipocytokines.
|
22607892 |
2012 |
|
Essential Hypertension
|
0.070 |
Biomarker
|
disease |
BEFREE |
Essential hypertension (EH) is often accompanied by hyperinsulinemia/insulin resistance (IR) and deranged adiponectin secretion.
|
23822941 |
2013 |
|
Hyperinsulinism
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Increased insulin and decreased adiponectin levels along with endothelial dysfunction are present in normotensive subjects with FT. IR and hypoadiponectinemia are interrelated, but only hyperinsulinemia has an independent adverse influence on endothelial function.
|
23822941 |
2013 |
|
Decreased Concentration
|
0.040 |
GeneticVariation
|
phenotype |
BEFREE |
Decreased concentration of adiponectin was associated with -11377C>G polymorphism (p<0.001); this polymorphism was significantly more frequent in the metabolic syndrome group than in the control group (p<0.001).
|
24561985 |
2014 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Obesity in pregnancy is associated with negative regulation of adpN adipose expression with increase in adpN DNA methylation associated with lower mRNA concentrations and hypoadiponectinemia.
|
24796925 |
2014 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Obesity, a known risk factor for liver fibrosis is associated with reduced levels of adiponectin, a protein that inhibits liver fibrosis in vivo and limits HSC proliferation and migration in vitro.
|
25575598 |
2015 |
|
Lipodystrophy
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lipodystrophies (LD) are genetic or acquired disorders sharing the symptom of partial or complete adipose tissue deficiency and a dysregulation of adipokines including leptin and adiponectin.
|
27497155 |
2016 |
|
Overweight and obesity
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Overweight and obesity and adiponectin levels may be useful as markers in HSCT survivors.
|
28039914 |
2017 |
|
Hypoadiponectinemia
|
0.500 |
Biomarker
|
disease |
BEFREE |
Hypoadiponectinemia and adiponectin resistance are implicated in the aetiology of obesity-related cardiometabolic disorders, hence represent a potential therapeutic axis.
|
28145500 |
2017 |
|
Mammary Tumorigenesis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Mammary tumorigenesis reduced plasma levels of adiponectin compared to non-tumor-bearing controls.
|
29032404 |
2018 |
|
Obesity
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Obesity and the metabolic syndrome (MS) are characterized by an increase in circulating leptin concentrations, in parallel to a decrease in blood levels of adiponectin.
|
29205099 |
2018 |
|
Obesity
|
0.600 |
Biomarker
|
disease |
BEFREE |
Obesity was associated with higher adiponectin-resistin index value in sera (P < 0.0001) and decreased in subcutaneous adipose tissue (P < 0.001), but only adiponectin-resistin index measured in sera was significantly higher in obese with the metabolic syndrome (P = 0.04).
|
29213336 |
2017 |
|
Lipodystrophy
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Lipodystrophy was only associated with increased macrophage infiltration (P = .04) and adiponectin messenger ribonucleic acid ([mRNA] P = .008), whereas metabolic syndrome was associated with larger adipocytes (P < .0001), decreased expression of genes related to adipogenesis and adipocyte function (P values between <.0001 and .08), increased leptin mRNA (P = .04), and a trend towards increased expression of inflammatory genes (P values between .08 and .6).
|
29788076 |
2018 |
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease.
|
29869823 |
2018 |
|
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Breast cancer survivors showed significant improvements in metabolic risk biomarkers and insulin resistance indicators along with a non-significant leptin decrease and a significant adiponectin decrease.
|
29869823 |
2018 |
|
Hyperinsulinism
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Increased insulin as well as HOMA-IR levels and decreased adiponectin levels were found in VPA treated subjects when compared to the newly diagnosed patients.
|
29906708 |
2018 |
|
Lupus Erythematosus, Systemic
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
SLE disease activity and complement components may suggest regulatory effect of adipokines (adiponectin and leptin) on disease pathogenesis.
|
30098476 |
2018 |