|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Stress, Psychological
|
|
0.010 |
GeneticVariation |
BEFREE |
The current study explored the effect of rs110402 genotype on psychological stress processing in healthy adults.
|
30447186 |
2019 |
|
rs17689918
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Post-Traumatic Stress Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
Logistic and linear regression was used to examine the associations between the FKBP5 SNP rs1360780 and the CRHR1 SNP rs17689918 with PTSD diagnosis and severity, as well as general psychiatric symptom severity, separately for current and remitted PTSD patients.
|
31291236 |
2019 |
|
rs17689918
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Antisocial behavior
|
|
0.010 |
GeneticVariation |
BEFREE |
We assess the effects of CRHR1 variant (rs17689918)-by-environment interactions on emotionality and behavioral traits, including anxiety, depression, aggression and antisocial behaviors.
|
29772307 |
2018 |
|
rs17689918
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Mixed anxiety and depressive disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
We assess the effects of CRHR1 variant (rs17689918)-by-environment interactions on emotionality and behavioral traits, including anxiety, depression, aggression and antisocial behaviors.
|
29772307 |
2018 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Post-Traumatic Stress Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
However, subjects who had experienced a moderate or severe history of childhood abuse and who were also GG homozygotes for rs110402 showed significant improvement after treatment with GSK561679 (n = 6) but not with placebo (n = 7) on the PTSD Symptom Scale-Self-Report.
|
28793974 |
2017 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Drug abuse
|
|
0.010 |
GeneticVariation |
BEFREE |
However, subjects who had experienced a moderate or severe history of childhood abuse and who were also GG homozygotes for rs110402 showed significant improvement after treatment with GSK561679 (n = 6) but not with placebo (n = 7) on the PTSD Symptom Scale-Self-Report.
|
28793974 |
2017 |
|
rs12944712
|
CRHR1;LINC02210-CRHR1
|
Major Depressive Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
The sample was subdivided according to sex and smoking status RESULTS: Among nonsmokers, there were nominal associations between MDD and all tested SNPs (rs12944712, P=0.042; rs110402, P=0.031, and rs878886, P=0.040), regardless of sex.
|
27544317 |
2016 |
|
rs17689918
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Panic Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor allele of rs17689918 was found to significantly increase risk for PD in females after Bonferroni correction and furthermore decreased CRHR1 mRNA expression in human forebrains and amygdalae.
|
26324098 |
2016 |
|
rs17689918
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Anxiety
|
|
0.010 |
GeneticVariation |
BEFREE |
When investigating neural correlates underlying this association in patients with PD using functional magnetic resonance imaging, risk allele carriers of rs17689918 showed aberrant differential conditioning predominantly in the bilateral prefrontal cortex and safety signal processing in the amygdalae, arguing for predominant generalization of fear and hence anxious apprehension.
|
26324098 |
2016 |
|
rs1876828
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
Eighty-two children (56 boys/26 girls, mean age 9.6 ± 3.2 years) with moderate-severe asthma exacerbation were genotyped for eight single-nucleotide polymorphisms that were a priori associated with ICS response in chronic asthma treatment: glucocorticosteroid receptor (NR3C1) rs41423247; corticotrophin-releasing hormone receptor1 (CRHR1) rs242939, rs242941, and rs1876828; T-box 21 (TBX21) rs2240017; glucocorticoid-induced transcript 1 (GLCCl1); and T gene rs3099266 and rs2305089.
|
27003716 |
2016 |
|
rs242939
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
Eighty-two children (56 boys/26 girls, mean age 9.6 ± 3.2 years) with moderate-severe asthma exacerbation were genotyped for eight single-nucleotide polymorphisms that were a priori associated with ICS response in chronic asthma treatment: glucocorticosteroid receptor (NR3C1) rs41423247; corticotrophin-releasing hormone receptor1 (CRHR1) rs242939, rs242941, and rs1876828; T-box 21 (TBX21) rs2240017; glucocorticoid-induced transcript 1 (GLCCl1); and T gene rs3099266 and rs2305089.
|
27003716 |
2016 |
|
rs242941
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Asthma
|
|
0.010 |
GeneticVariation |
BEFREE |
Eighty-two children (56 boys/26 girls, mean age 9.6 ± 3.2 years) with moderate-severe asthma exacerbation were genotyped for eight single-nucleotide polymorphisms that were a priori associated with ICS response in chronic asthma treatment: glucocorticosteroid receptor (NR3C1) rs41423247; corticotrophin-releasing hormone receptor1 (CRHR1) rs242939, rs242941, and rs1876828; T-box 21 (TBX21) rs2240017; glucocorticoid-induced transcript 1 (GLCCl1); and T gene rs3099266 and rs2305089.
|
27003716 |
2016 |
|
rs878886
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Major Depressive Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
The sample was subdivided according to sex and smoking status RESULTS: Among nonsmokers, there were nominal associations between MDD and all tested SNPs (rs12944712, P=0.042; rs110402, P=0.031, and rs878886</span>, P=0.040), regardless of sex.
|
27544317 |
2016 |
|
rs242941
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Perinatal depression in mother
|
|
0.010 |
GeneticVariation |
BEFREE |
There was no statistically significant association of perinatal depression for CRHR1 rs242941 and GR rs41423247 (BclI).
|
26518448 |
2015 |
|
rs242941
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Asthma attack
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus, CRHR1 gene SNP rs242941 polymorphism is associated with better response to systemic corticosteroid during acute exacerbation of asthma.
|
25712009 |
2015 |
|
rs242941
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Mental disorders
|
|
0.010 |
GeneticVariation |
BEFREE |
When all subjects were grouped based on family history of mental illness, there was a statistically significant association of CRHR1 rs242941 with family history regardless of depression status (P = 0.043).
|
26518448 |
2015 |
|
rs242948
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Infantile Spasm
|
|
0.010 |
GeneticVariation |
BEFREE |
Under the assumption of the dominant model, the selected five SNPs, rs4458044, rs171440, rs17689966, rs28364026 and rs242948, showed no association with the risk of infantile spasms and the effectiveness of adrenocorticotropic hormone treatment.
|
25954915 |
2015 |
|
rs242948
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
West Syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
Under the assumption of the dominant model, the selected five SNPs, rs4458044, rs171440, rs17689966, rs28364026 and rs242948, showed no association with the risk of infantile spasms and the effectiveness of adrenocorticotropic hormone treatment.
|
25954915 |
2015 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Alcoholic Intoxication, Chronic
|
|
0.010 |
GeneticVariation |
BEFREE |
This study examined the influence of an intronic CRHR1 gene variant, rs110402, on brain responses to negative emotional words, negative emotional traits, and alcohol use in adolescents and young adults at high risk for alcoholism.
|
24623788 |
2014 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Depressive Symptoms
|
|
0.010 |
GeneticVariation |
BEFREE |
Participants were assessed prospectively for EA up to age 5 and recent chronic stress and depressive symptoms at age 20 and genotyped for CRHR1 single nucleotide polymorphism rs110402 and 5-HTTLPR.
|
25422958 |
2014 |
|
rs12944712
|
CRHR1;LINC02210-CRHR1
|
child abuse behavior
|
|
0.010 |
GeneticVariation |
BEFREE |
FKBP5 (rs1360780) and CRHR1 (rs12944712) polymorphisms significantly interacted with child abuse and adult stress to predict increases in physical health ailments over 3 years.
|
24099078 |
2014 |
|
rs1876831
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Depressive Symptoms
|
|
0.010 |
GeneticVariation |
BEFREE |
To determine if single nucleotide polymorphisms of the corticotrophin-releasing hormone binding protein (CRHBP, rs10055255) and CRH receptor type 1 (CRHR1, rs1876831) were associated with posttraumatic stress disorder (PTSD) and depressive symptoms following medical-surgical intensive care unit (ICU) hospitalization.
|
24075295 |
2014 |
|
rs1876831
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Post-Traumatic Stress Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
To determine if single nucleotide polymorphisms of the corticotrophin-releasing hormone binding protein (CRHBP, rs10055255) and CRH receptor type 1 (CRHR1, rs1876831) were associated with posttraumatic stress disorder (PTSD) and depressive symptoms following medical-surgical intensive care unit (ICU) hospitalization.
|
24075295 |
2014 |
|
rs16940655
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Mood Disorders
|
|
0.010 |
GeneticVariation |
BEFREE |
By single marker analysis we have found an association of rs28536160 of AVPR1b and rs4076452 and rs16940655 of CRHR1 with mood disorders (P=0.036, 0.0013, and 0.003, respectively).
|
23962971 |
2013 |
|
rs173365
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Alcoholic Intoxication, Chronic
|
|
0.010 |
GeneticVariation |
BEFREE |
In block 2, rs17689966 (P = 0.018) showed significant and rs173365 (P = 0.026) showed nominally significant, gene × environment (G × E) effects on alcoholism status.
|
23473364 |
2013 |