|
rs17689882
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Depressive Symptoms
|
|
0.010 |
GeneticVariation |
BEFREE |
Specifically, we found that the impact of childhood maltreatment on adult depressive symptoms was significantly higher in individuals (i) with two copies of the CRHR1 TAT haplotype, and (ii) homozygous for the G allele of rs17689882.
|
22748421 |
2013 |
|
rs17689966
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Alcoholic Intoxication, Chronic
|
|
0.010 |
GeneticVariation |
BEFREE |
In block 2, rs17689966 (P = 0.018) showed significant and rs173365 (P = 0.026) showed nominally significant, gene × environment (G × E) effects on alcoholism status.
|
23473364 |
2013 |
|
rs1876828
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Depressive disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
The BclI and ER22/23EK single nucleotide polymorphisms (SNPs) of the GR and the haplotype-tagged rs1876828, rs242939 and rs242941 SNPs of the CRHR1 associated with genetic risk to depressive disorders were genotyped.
|
23726670 |
2013 |
|
rs242939
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Depressive disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
The BclI and ER22/23EK single nucleotide polymorphisms (SNPs) of the GR and the haplotype-tagged rs1876828, rs242939 and rs242941 SNPs of the CRHR1 associated with genetic risk to depressive disorders were genotyped.
|
23726670 |
2013 |
|
rs242941
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate the possible relationship between genetic risk factors and depression in AD, we assessed genetic polymorphisms reported to be associated with depression (MAOA VNTR, ACE 288bp Insertion/ Deletion, 5HTTLPR, COMT Val158Met, BDNF Val66Met, TPH1 A218C, HTR2A T102C, P2RX7 Q460R, FKBP5 rs1360780 and CRHR1 rs242941) in a cross-sectional study on 246 AD patients with or without clinically significant major depressive disorder (MDD) according to DSM-IV.
|
23157339 |
2013 |
|
rs4792887
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Post-Traumatic Stress Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
After correction for multiple testing, rs12938031 and rs4792887 remained associated with post-hurricane PTSD symptoms.
|
24077033 |
2013 |
|
rs4792888
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Major Depressive Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
Only rs4792888 in CRHR1 showed modest evidence of association with duloxetine response in MDD (P=0.029 in GAD, P=0.054 in MDD).
|
22249355 |
2013 |
|
rs4792888
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Generalized Anxiety Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
Only rs4792888 in CRHR1 showed modest evidence of association with duloxetine response in MDD (P=0.029 in GAD, P=0.054 in MDD).
|
22249355 |
2013 |
|
rs7209436
|
CRHR1;LINC02210-CRHR1
|
Anxiety Disorders
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed interactions between trait anxiety and rs7209436 and rs110402 in CRHR1 in association with baseline cortisol (p LRT = 0.0272 and p LRT = 0.0483, respectively).
|
23274505 |
2013 |
|
rs7209436
|
CRHR1;LINC02210-CRHR1
|
Anxiety
|
|
0.010 |
GeneticVariation |
BEFREE |
We observed interactions between trait anxiety and rs7209436 and rs110402 in CRHR1 in association with baseline cortisol (p LRT = 0.0272 and p LRT = 0.0483, respectively).
|
23274505 |
2013 |
|
rs173365
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Major Depressive Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
The T-A-T-G-G haplotype consisting of rs7209436 and rs173365 in CRHR1 was positively associated with MDD.
|
22467522 |
2012 |
|
rs173365
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Panic Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
To confirm the association of CRHR1 and CRHR2 with MDD and PD, we investigated 12 single nucleotide polymorphisms (SNPs) (rs4076452, rs7209436, rs110402, rs242924, rs242940, and rs173365 for CRHR1 and rs4722999, rs3779250, rs2267710, rs1076292, rs2284217, and rs226771 for CRHR2) in MDD patients (n = 173), PD patients (n = 180), and healthy controls (n = 285).
|
22467522 |
2012 |
|
rs242924
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Major Depressive Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNP rs110402 and rs242924 in the CRHR1 gene and the rs3779250 in the CRHR2 gene were associated with MDD.
|
22467522 |
2012 |
|
rs242924
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Panic Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
The SNP rs242924 in the CRHR1 gene was also associated with PD.
|
22467522 |
2012 |
|
rs7209436
|
CRHR1;LINC02210-CRHR1
|
Fragile X Syndrome
|
|
0.010 |
GeneticVariation |
BEFREE |
Results indicate a statistically significant interaction between CRHR1 genotype and the status of raising a child with FXS to predict social anxiety symptoms reported on the SPAI (rs7209436, P = 0.0001).
|
22573456 |
2012 |
|
rs7209436
|
CRHR1;LINC02210-CRHR1
|
Major Depressive Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
The T-A haplotype consisting of rs7209436 and rs110402 in CRHR1 was positively associated with MDD.
|
22467522 |
2012 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Alcohol Use Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
An interaction of CRHR1 rs110402 and CRHBP rs3811939 predicts high risk of comorbid AUD in schizophrenic patients (odds ratio = 2.27; 95% confidence interval, 1.56-3.30; P < .001) as well as psychiatric disease controls (odds ratio = 4.02; 95% confidence interval, 0.95-17.05; P = .06) and leads to the highest CRHR1/CRHBP messenger RNA ratio (P = .02; dysbalanced stress axis).
|
21810631 |
2011 |
|
rs12944712
|
CRHR1;LINC02210-CRHR1
|
Post-Traumatic Stress Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
Results indicated that multiple SNPs were associated with acute symptoms at a univariate level, and after correction for multiple testing, rs12944712 was significantly related to acute PTSD symptoms.
|
21508513 |
2011 |
|
rs12936511
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Mental Depression
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus, while the characteristics of the suicide female attempters remained undetermined, the male suicidal offspring had increased depression intensity related to main genetic effects by exonic SNP rs12936511 and homozygous non-CGC haplotypes.
|
19220485 |
2009 |
|
rs12936511
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Mental disorders
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor T-allele of exonic SNP rs12936511, not previously studied in the context of psychiatric disorders and suicidal behaviors, was significantly transmitted to suicidal males with increased Beck Depression Inventory (BDI) scores (n = 347; P = 0.0028).
|
19220485 |
2009 |
|
rs12936511
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Depressed mood
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus, while the characteristics of the suicide female attempters remained undetermined, the male suicidal offspring had increased depression intensity related to main genetic effects by exonic SNP rs12936511 and homozygous non-CGC haplotypes.
|
19220485 |
2009 |
|
rs12936511
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Abnormal behavior
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor T-allele of exonic SNP rs12936511, not previously studied in the context of psychiatric disorders and suicidal behaviors, was significantly transmitted to suicidal males with increased Beck Depression Inventory (BDI) scores (n = 347; P = 0.0028).
|
19220485 |
2009 |
|
rs12936511
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Depressive disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus, while the characteristics of the suicide female attempters remained undetermined, the male suicidal offspring had increased depression intensity related to main genetic effects by exonic SNP rs12936511 and homozygous non-CGC haplotypes.
|
19220485 |
2009 |
|
rs4792887
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Depressed mood
|
|
0.010 |
GeneticVariation |
BEFREE |
To comprehensively map the genetic variation in CRHR1 in relation to suicidality and depression, as a follow-up to our initial report on SNP rs4792887, we analyzed six new single nucleotide polymorphisms (SNPs), in an extended sample of family trios (n = 672) with suicide attempter offspring, by using family-based association tests.
|
19220485 |
2009 |
|
rs4792887
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Mental Depression
|
|
0.010 |
GeneticVariation |
BEFREE |
To comprehensively map the genetic variation in CRHR1 in relation to suicidality and depression, as a follow-up to our initial report on SNP rs4792887, we analyzed six new single nucleotide polymorphisms (SNPs), in an extended sample of family trios (n = 672) with suicide attempter offspring, by using family-based association tests.
|
19220485 |
2009 |