|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Anxiety Disorders
|
|
0.030 |
GeneticVariation |
BEFREE |
It has been proposed that the common intronic CRHR1 SNP rs110402 is associated with anxiety and cortisol response patterns and plays a key role in vulnerability to certain mental disorders.
|
30447186 |
2019 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Major Depressive Disorder
|
|
0.030 |
GeneticVariation |
BEFREE |
Results from healthy controls and a preliminary sample of MDD participants show that CRHR1 single nucleotide polymorphism rs110402 moderates neural responses to emotional stimuli, suggesting a potential mechanism of vulnerability for the development of MDD.
|
22378896 |
2012 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Major Depressive Disorder
|
|
0.030 |
GeneticVariation |
BEFREE |
The T-A haplotype consisting of rs7209436 and rs110402 in CRHR1 was positively associated with MDD.
|
22467522 |
2012 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Anxiety Disorders
|
|
0.030 |
GeneticVariation |
BEFREE |
Here, we provide clinical translation for the importance of these molecular interactions using an imaging genetics strategy to examine whether interactions between genetic polymorphisms associated with differential anandamide (FAAH rs324420) and CRF1 (CRHR1 rs110402) signaling modulate amygdala function and anxiety disorder diagnosis.
|
26923505 |
2016 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
child abuse behavior
|
|
0.030 |
GeneticVariation |
BEFREE |
We then extended our previously reported interaction with both a CRHR1 SNP (rs110402) and TCA haplotype interacting with child abuse to predict current symptoms (N = 1,059; P = 0.0089).
|
20029939 |
2010 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
child abuse behavior
|
|
0.030 |
GeneticVariation |
BEFREE |
While GSK561679 was not superior to placebo overall, it was associated with a significantly stronger symptom reduction in a subset of patients with probable CRF system hyperactivity, i.e., patients with child abuse and CRHR1 SNP rs110402 GG carriers.
|
30390684 |
2018 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Anxiety Disorders
|
|
0.030 |
GeneticVariation |
BEFREE |
We observed interactions between trait anxiety and rs7209436 and rs110402 in CRHR1 in association with baseline cortisol (p LRT = 0.0272 and p LRT = 0.0483, respectively).
|
23274505 |
2013 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Major Depressive Disorder
|
|
0.030 |
GeneticVariation |
BEFREE |
The association of the CRHR1 SNPs rs12944712, rs110402, and rs878886 with MDD was evaluated in 629 Brazilian adults of European descent recruited from the general population [180 (28.6%) with lifetime MDD].
|
27544317 |
2016 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
child abuse behavior
|
|
0.030 |
GeneticVariation |
BEFREE |
This study examined the contributions of a polymorphism of the corticotropin-releasing hormone receptor type I (CRHR1) gene (rs110402) and a history of child maltreatment--alone and in interaction--to patterns of cortisol reactivity in adolescents.
|
24703172 |
2014 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Mental disorders
|
|
0.020 |
GeneticVariation |
BEFREE |
An interaction of CRHR1 rs110402 and CRHBP rs3811939 predicts high risk of comorbid AUD in schizophrenic patients (odds ratio = 2.27; 95% confidence interval, 1.56-3.30; P < .001) as well as psychiatric disease controls (odds ratio = 4.02; 95% confidence interval, 0.95-17.05; P = .06) and leads to the highest CRHR1/CRHBP messenger RNA ratio (P = .02; dysbalanced stress axis).
|
21810631 |
2011 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Mental disorders
|
|
0.020 |
GeneticVariation |
BEFREE |
It has been proposed that the common intronic CRHR1 SNP rs110402 is associated with anxiety and cortisol response patterns and plays a key role in vulnerability to certain mental disorders.
|
30447186 |
2019 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Anxiety
|
|
0.020 |
GeneticVariation |
BEFREE |
It has been proposed that the common intronic CRHR1 SNP rs110402 is associated with anxiety and cortisol response patterns and plays a key role in vulnerability to certain mental disorders.
|
30447186 |
2019 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Anxiety
|
|
0.020 |
GeneticVariation |
BEFREE |
We observed interactions between trait anxiety and rs7209436 and rs110402 in CRHR1 in association with baseline cortisol (p LRT = 0.0272 and p LRT = 0.0483, respectively).
|
23274505 |
2013 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Stress, Psychological
|
|
0.010 |
GeneticVariation |
BEFREE |
The current study explored the effect of rs110402 genotype on psychological stress processing in healthy adults.
|
30447186 |
2019 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Post-Traumatic Stress Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
However, subjects who had experienced a moderate or severe history of childhood abuse and who were also GG homozygotes for rs110402 showed significant improvement after treatment with GSK561679 (n = 6) but not with placebo (n = 7) on the PTSD Symptom Scale-Self-Report.
|
28793974 |
2017 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Drug abuse
|
|
0.010 |
GeneticVariation |
BEFREE |
However, subjects who had experienced a moderate or severe history of childhood abuse and who were also GG homozygotes for rs110402 showed significant improvement after treatment with GSK561679 (n = 6) but not with placebo (n = 7) on the PTSD Symptom Scale-Self-Report.
|
28793974 |
2017 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Alcoholic Intoxication, Chronic
|
|
0.010 |
GeneticVariation |
BEFREE |
This study examined the influence of an intronic CRHR1 gene variant, rs110402, on brain responses to negative emotional words, negative emotional traits, and alcohol use in adolescents and young adults at high risk for alcoholism.
|
24623788 |
2014 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Alcohol Use Disorder
|
|
0.010 |
GeneticVariation |
BEFREE |
An interaction of CRHR1 rs110402 and CRHBP rs3811939 predicts high risk of comorbid AUD in schizophrenic patients (odds ratio = 2.27; 95% confidence interval, 1.56-3.30; P < .001) as well as psychiatric disease controls (odds ratio = 4.02; 95% confidence interval, 0.95-17.05; P = .06) and leads to the highest CRHR1/CRHBP messenger RNA ratio (P = .02; dysbalanced stress axis).
|
21810631 |
2011 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Depressive Symptoms
|
|
0.010 |
GeneticVariation |
BEFREE |
Participants were assessed prospectively for EA up to age 5 and recent chronic stress and depressive symptoms at age 20 and genotyped for CRHR1 single nucleotide polymorphism rs110402 and 5-HTTLPR.
|
25422958 |
2014 |
|
rs110402
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Depressive episode, unspecified
|
|
0.010 |
GeneticVariation |
BEFREE |
rs110402, in CRHR1 gene, was associated with an increased risk to present a seasonal pattern and an early age of onset of the first depressive episode.
|
17467808 |
2007 |
|
rs12150390
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Parkinson Disease
|
|
0.700 |
GeneticVariation |
GWASDB |
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.
|
22438815 |
2012 |
|
rs12936511
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Mental Depression
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus, while the characteristics of the suicide female attempters remained undetermined, the male suicidal offspring had increased depression intensity related to main genetic effects by exonic SNP rs12936511 and homozygous non-CGC haplotypes.
|
19220485 |
2009 |
|
rs12936511
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Mental disorders
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor T-allele of exonic SNP rs12936511, not previously studied in the context of psychiatric disorders and suicidal behaviors, was significantly transmitted to suicidal males with increased Beck Depression Inventory (BDI) scores (n = 347; P = 0.0028).
|
19220485 |
2009 |
|
rs12936511
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Depressed mood
|
|
0.010 |
GeneticVariation |
BEFREE |
Thus, while the characteristics of the suicide female attempters remained undetermined, the male suicidal offspring had increased depression intensity related to main genetic effects by exonic SNP rs12936511 and homozygous non-CGC haplotypes.
|
19220485 |
2009 |
|
rs12936511
|
CRHR1;MAPT-AS1;LINC02210-CRHR1
|
Abnormal behavior
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor T-allele of exonic SNP rs12936511, not previously studied in the context of psychiatric disorders and suicidal behaviors, was significantly transmitted to suicidal males with increased Beck Depression Inventory (BDI) scores (n = 347; P = 0.0028).
|
19220485 |
2009 |