|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation |
BEFREE |
For four candidate SNPs (rs780094, rs10830963, rs7903146, and rs4607517), the strength of association between genotype and glucose was significantly (P-interaction<0.05) different in those with and without prevalent diabetes, and for all five fasting glucose candidate SNPs (rs780094, rs10830963, rs560887, rs4607517, and rs13266634) the association with measured fasting glucose was more significant in the smaller sample without prevalent diabetes than in the larger combined sample of those with and without diabetes.
|
20839289 |
2010 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation |
BEFREE |
Zinc supplementation appears to affect the early insulin response to glucose differentially by rs13266634 genotype and could be beneficial for diabetes prevention and/or treatment for some individuals based on SLC30A8 variation.
|
25348609 |
2015 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that the diabetes risk genotype C/C at rs13266634 is associated with higher islet Zn concentration (C/C genotype: 16792 ± 1607, n = 22, C/T genotype: 11221 ± 1245, n = 18 T/T genotype: 11543 ± 6054, n = 3, all values expressed as mean nmol/g protein ± standard error of the mean, p = 0.040 by ANOVA).
|
28352089 |
2017 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation |
BEFREE |
Diabetes genomics research has illuminated single nucleotide polymorphism (SNP) in several genes including, fat mass and obesity associated (FTO) (rs9939609 and rs9926289), potassium voltage-gated channel subfamily J member 11 (rs5219), SLC30A 8 (rs13266634) and peroxisome proliferator-activated receptor gamma 2 (rs1805192).
|
31823921 |
2019 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation |
BEFREE |
ZnT8 Arg325Trp polymorphism influences zinc transporter expression and cytokine production in PBMCs from patients with diabetes.
|
30142362 |
2018 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation |
BEFREE |
We searched all the publications about the association between SLC30A8 and diabetes from PubMed, and evaluated the association between SLC30A8 rs13266634 C/T polymorphism and T2DM, IGT and T1DM, respectively, by meta-analysis of all the validated studies.
|
21131091 |
2011 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation |
BEFREE |
Moreover, overexpression of human ZnT8 diabetes high-risk allele R325W increased 5-HT levels relative to the low-risk allele in RIN14B cells.
|
30936149 |
2019 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation |
BEFREE |
Moreover, ZnT8A-COOH-positive children who carried homozygous SLC30A8 SNP rs13266634 genotypes progressed faster to diabetes than those who were heterozygous (59% [95% CI 42.3-75.7%] vs 22% [95% CI 0-44.3%] within 5 years; p = 0.01).
|
19590848 |
2009 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphism rs13266634 in SLC30A8 causes abnormal synthesis, maturation and secretion of insulin, resulting in decrease in efficiency of glucose metabolism and diabetes.
|
30633652 |
2020 |
|
rs4876369
|
SLC30A8;LOC105375716
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation |
BEFREE |
Diabetes status modified the associations between rs4876369 and rs2241745 and BC incidence, on the multiplicative interaction scale.
|
30457165 |
2019 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.070 |
GeneticVariation |
BEFREE |
The present study along with the meta-analysis does not show any substantial association of the rs13266634 C/T polymorphism with T1D development in this population.
|
30197307 |
2019 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.070 |
GeneticVariation |
BEFREE |
A common variant W325R in the C-terminal domain (CTD) increases the risk to develop type 2 diabetes and affects autoantibody specificity in type 1 diabetes.
|
29430817 |
2018 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.070 |
GeneticVariation |
BEFREE |
Our meta-analysis results revealed the significant association between rs13266634 C/T polymorphism and T2DM and IGT, but did not support the association between this polymorphism and T1DM.
|
21131091 |
2011 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.070 |
GeneticVariation |
BEFREE |
No evidence of an association between rs13266634 and type 1 diabetes was observed.
|
18850084 |
2008 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.070 |
GeneticVariation |
BEFREE |
Our study confirms ZnT8 as a major target for autoantibodies at disease onset in our Danish T1D cohort of children and adolescents, and we have further characterised the relationship between autoantibody specificity for the ZnT8 Arg325Trp epitopes and rs13266634 in relation to established autoantibodies, AAD, measures of β-cell function and HLA-DQB1 genotypes in T1D.
|
20836749 |
2011 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.070 |
GeneticVariation |
BEFREE |
The genetic determination of the rs13266634 variant on the ZnT8Ab specificity is sustained the first 12 months after the diagnosis of type 1 diabetes in a pediatric cohort.
|
21604969 |
2011 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.070 |
GeneticVariation |
BEFREE |
The prevalence and predictive value of the SLC30A8 R325W polymorphism and zinc transporter 8 autoantibodies in the development of GDM and postpartum type 1 diabetes.
|
27003436 |
2016 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
C |
1.000 |
GeneticVariation |
GWASCAT |
A genome-wide association study identifies novel risk loci for type 2 diabetes.
|
17293876 |
2007 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
C |
1.000 |
GeneticVariation |
GWASCAT |
Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes.
|
17463249 |
2007 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation |
BEFREE |
In Chinese Han, we replicated the associations between 7 genetic loci and T2D, with risk allele-specific odds ratios (ORs) as follows: 1.27 (95% CI, 1.11-1.45; p = 0.0008) for CDKAL1-rs10946398, 1.26 (95% CI, 1.08-1.47; p = 0.003) for IGF2BP2-rs4402960, 1.19 (95% CI, 1.04-1.37; p = 0.009) for SLC30A8-rs13266634, 1.22 (95% CI, 1.06-1.41; p = 0.005) for CDKN2A/B-rs10811661, 1.20 (95% CI, 1.01-1.42; p = 0.03) for HHEX-rs5015480, 1.37 (95% CI, 1.19-1.69; p = 1.0 x 10(-4)) for KCNQ1-rs2237892, and 1.24 (95% CI, 1.01-1.52; p = 0.046) for FTO-rs8050136 after adjustment for age, gender, and body mass index.
|
20509872 |
2010 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation |
BEFREE |
We replicated the association with type 2 diabetes for rs10811661 in the vicinity of CDKN2B (OR 1.20, 95% CI: 1.06-1.37, p=0.004), rs9939609 in FTO (OR 1.14, 95% CI: 1.04-1.25, p=0.006) and rs13266634 in SLC30A8 (OR 1.20, 95% CI: 1.09-1.33, p=3.9 x 10(-4)).
|
18437351 |
2008 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation |
BEFREE |
A significant association with type 2 diabetes was not observed for rs13266634.
|
17971426 |
2008 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation |
BEFREE |
The variant rs13266634 in SLC30A8, encoding a β-cell-specific zinc transporter, is associated with type 2 diabetes.
|
24471563 |
2014 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation |
BEFREE |
We estimate that the rs13266634 single nucleotide polymorphism, a type 2 diabetes susceptibility genotype, has a genetic prevalence of 56.3%, 47.4% and 37.0% in Mexican Mestizo, Caucasian, and Asian populations.
|
25875676 |
2015 |
|
rs13266634
|
SLC30A8;LOC105375716
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
1.000 |
GeneticVariation |
BEFREE |
Our results suggest that rs13266634 may be an important genetic factor of type 2 diabetes risk among Asian and European but not African populations.
|
26214053 |
2015 |