|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Obesity risk is associated with carbohydrate intake in women carrying the Gln27Glu beta2-adrenoceptor polymorphism.
|
12888635 |
2003 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate whether polymorphisms in the beta(2)-adrenergic receptor gene (5'LC-Arg19Cys, Arg16Gly, Gln27Glu) are associated with hypertension in patients with or without type 2 diabetes and with the blood pressure levels in normotensive sib pairs.
|
11358945 |
2001 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Neither the Arg16Gly nor Gln27Glu polymorphisms showed evidence of linkage to qualitative measures of asthma and bronchial hyperresponsiveness (BHR) (p > 0.10) or to quantitative measures of serum IgE and airway reactivity (p > 0.10).
|
10934093 |
2000 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
We evaluated Gln27Glu polymorphism in the β2AR gene in obese Saudi populations to investigate the association of β2AR gene with obesity</span> and other related metabolic parameters.
|
20738880 |
2010 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent studies have suggested that two polymorphisms of the beta(2)-adrenergic receptor (beta(2)AR) gene at codons 16 (arginine to glycine) and 27 (glutamine to glutamate) affect an individual's airway responsiveness, or response to acute or chronic beta(2)-agonist therapy but are not risk factors for asthma.
|
11371409 |
2001 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The ADRbeta2 variations Gly(16)Arg and Gln(27)Glu and, more recently, haplotypic variations, have been the focus of numerous pharmacogenetic studies looking at responses to short-acting (SABA) and long-acting beta-agonists (LABA) in subjects with asthma.
|
18303970 |
2008 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results suggest that in the group of mestizo schoolchildren studied, the Arg16Gly and Gln27Glu polymorphisms are not markers of susceptibility or severity of asthma and do not affect ADRB2 gene expression during the rescue therapy.
|
22328447 |
2012 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Expression of the C7</span>9G polymorphism of the ADRB2 gene was significantly associated with risk of pediatric asthma associated with the C or G allele with comparison of the co-dominant model (GG vs. CC: OR, 0.69; 95% CI, 0.55-0.88) and the recessive model (GG vs. CC+CG: OR, 0.65; 95% CI, 0.53-0.81).
|
31142730 |
2019 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Gln27Glu polymorphism was markedly associated with obesity with a relative risk for obesity of approximately 7 and an odds ratio of approximately 10.
|
9399946 |
1997 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the association between polymorphisms in the beta(2)-adrenergic receptor gene (ADRB2) (-47C/T, Arg16/Gly, Gln27/Glu) and stage-2 hypertension in northern Han Chinese.
|
15638826 |
2005 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Glu27Gln polymorphism had no significant effect on asthma exacerbations in any treatment group.
|
16772309 |
2006 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study indicates that the ADRB2 rs1042714 SNP may contribute to the risk of obesity and predict obesity-related metabolic traits such as BMI, triglyceride, and systolic blood pressure in Taiwanese subjects.
|
24322328 |
2014 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the age stratification analysis, C79G polymorphism owned a reduced effect on asth</span>ma risk for children (GG vs. CC: OR=0.69, p=0.002; GG vs. CC+CG: OR=0.65, p<0.001).
|
31115019 |
2019 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The summary odds ratio (OR) from overall analyses showed no association between either rs1042714 or rs1042713 and obesity.
|
19186333 |
2008 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings show that the risk of development of asthma or response to treatment can be, respectively, deciphered by the detection of both rs1042713 and rs1042714 variants in <i>ADRB2</i> gene.
|
30468638 |
2019 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that the Gln27Glu and Arg16Gly polymorphisms of the beta2AR gene are not a major contributing factor to obesity in Japanese men.
|
11016907 |
2000 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Additionally, for the polymorphic sites of BAR-2 (Arg16Gly and Gln27Glu) a significant effect on obesity risk was seen.
|
12395215 |
2002 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Interactions were detected between ADRA2A C-1291G and ADRB2 Gln27-->Glu variants for obesity in African Americans and between ADRA2A C-1291G SNP and ADBR1 haplotype for obesity in whites.
|
17512307 |
2007 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We studied beta 2-adrenoceptor genotype for the Gln/Glu 27 polymorphism and airway reactivity in 65 patients with mild to moderate asthma.
|
7739309 |
1995 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The findings suggest that the Arg16Gly and Gln27Glu polymorphisms in the β2-AR gene are associated with asthma severity and response to therapy and might be used in personalized treatment for these patients in the future.
|
30178312 |
2018 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Common Arg16Gly and Gln27Glu polymorphisms of the beta(2)-adrenergic receptor (beta(2)AR) have been associated with hypertension and coronary disease.
|
15797659 |
2005 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, the Gln27Glu beta2-ADR variant is excluded in HT, but might influence body weight.
|
11775127 |
2001 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis revealed that the rs1042714 (Gln27Glu) polymorphism is associated with obesity susceptibility.
|
24960039 |
2014 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Results for Gln/Glu27 in adults seem to indicate that heterozygotes are at decreased risk of asthma than either homozygote (odds ratio = 0.73, 95% CI: 0.62, 0.87), although the studies are heterogeneous; in children, the Glu/Glu genotype has a decreased risk of asthma (odds ratio = 0.60, 95% CI: 0.35, 0.99) compared with the other genotypes.
|
15987731 |
2005 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Even in Japanese-Americans, who have a more westernized life style than Japanese, the association of the beta(2)-AR gene (Gln27Glu) variant with the parameters of obesity, insulin resistance, and serum lipid level has yet to be clarified.
|
11288039 |
2001 |