|
COPD exacerbation
|
|
0.010 |
GeneticVariation
|
BEFREE |
In current users of β<sub>2</sub>-agonists, the risk of COPD exacerbation decreased by 30% (hazard ratio (HR); 0.70, 95% CI: 0.59-0.84) for each copy of the Arg allele of rs1042713 and by 20% (HR; 0.80, 95% CI: 0.69-0.94) for each copy of the Gln allele of rs1042714.
|
31683975 |
2019 |
|
Gestational Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate the correlations and interactions between the polymorphisms of insulin resistance-related genes (ADIPOQ rs2241766), inflammation factors (TNF-α rs1800629, IL-6 rs1800795), obesity-related genes (GNB3 rs5443, ADRB rs1042714), and risk factors for gestational diabetes mellitus (GDM) such as diet structure in the development of GDM.
|
29519182 |
2019 |
|
Ischemic cardiomyopathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
Polymorphism Gln27Glu of β2 Adrenergic Receptors in Patients with Ischaemic Cardiomyopathy.
|
28933308 |
2018 |
|
Multi vessel coronary artery disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
In HF patients concerning the differences in patient characteristics between allele categories (Gln27Gln vs. Gln27Glu/Glu27Glu) there was no difference in risk factors, LVEF, treatment, the clinical status and NYHA categorization of patients, and in the prevalence of multi-vessel coronary artery disease.
|
28933308 |
2018 |
|
Gastroschisis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs4961 (ADD1), rs5443 (GNB3), rs1042713, and rs1042714 (ADRB2) were significantly associated with gastroschisis.
|
29550988 |
2018 |
|
Tuberculosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The association was reported between rs1042713 and rs1042714 polymorphisms in ADRB2 gene and tuberculosis for the first time. rs1042713*G and rs1042714*G polymorphisms in ADRB2 gene makes people more susceptible to develop the disease.
|
27900465 |
2017 |
|
Tuberculosis, Pulmonary
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genotype distributions of the rs1042713 (Arg16Gly +46A>G) and rs1042714 (Gln27Glu +79C>G) polymorphisms in ADRB2 gene in 106 patients with pulmonary tuberculosis and 88 healthy subjects were studied by PCR-RFLP method in an Iranian population.
|
27900465 |
2017 |
|
Labor Pain
|
|
0.010 |
GeneticVariation
|
BEFREE |
Labor pain more rapidly became severe in parturients heterozygous or homozygous for the G allele at rs1042714 in the ADRB2 gene.
|
24714117 |
2014 |
|
Polycystic Ovary Syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
ADRB2 haplotypes (comprising rs1042711, rs1801704, rs1042713 and rs1042714 in that order), genotyping and statistical analysis to evaluate associations with continuous variables and traits related to IR and MS in a PCOS population.
|
22900502 |
2013 |
|
Metabolic Syndrome X
|
|
0.010 |
GeneticVariation
|
BEFREE |
ADRB2 haplotypes (comprising rs1042711, rs1801704, rs1042713 and rs1042714 in that order), genotyping and statistical analysis to evaluate associations with continuous variables and traits related to IR and MS in a PCOS population.
|
22900502 |
2013 |
|
Childhood asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Four ADRB2 single nucleotide polymorphisms (rs1042711, rs1042713, rs1042714 and rs1800888) were genotyped in 953 children from the prospective birth cohort 'Environment and Childhood Asthma' study and analysed for association with flow-volume parameters at birth (tidal breathing) and at 10 years of age (maximally forced), stratified by environmental exposures.
|
23463918 |
2013 |
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We evaluated the hypothesis that ADRB2 variants (rs1042713, rs1042714) are associated with breast cancer risk in non-Hispanic white (NHW) and Hispanic (H) women using data from a population-based case-control study conducted in the southwestern United States.
|
22864926 |
2012 |
|
Meningitis, Bacterial
|
|
0.010 |
GeneticVariation
|
BEFREE |
We identified a functional polymorphism in ADRB2 (rs1042714) to be associated with an increased risk for bacterial meningitis (Odds ratio [OR] 1.35, 95% confidence interval [CI] 1.04-1.76; p = 0.026).
|
22624056 |
2012 |
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
We evaluated the hypothesis that ADRB2 variants (rs1042713, rs1042714) are associated with breast cancer risk in non-Hispanic white (NHW) and Hispanic (H) women using data from a population-based case-control study conducted in the southwestern United States.
|
22864926 |
2012 |
|
Intermittent Claudication
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Gln(27)Glu polymorphism but not the Arg(16)Gly polymorphism of the beta2-adrenergic receptor (ADRB2) gene appears to be associated with a broad range of aging-associated phenotypes, including cancers at different sites, myocardial infarction (MI), intermittent claudication (IC), and overall/healthy longevity in the Framingham Heart Study Offspring cohort.
|
20399803 |
2010 |
|
Hyperinsulinism
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Gln27Glu polymorphism in β2-adrenergic receptor gene is linked to hypertriglyceridemia, hyperinsulinemia and hyperleptinemia in Saudis.
|
20738880 |
2010 |
|
High altitude pulmonary edema
|
|
0.010 |
GeneticVariation
|
BEFREE |
The haplotypes from 46A/G and 79C/G SNP of ADRB2 were associated with HAPE.
|
20546540 |
2010 |
|
Migraine Disorders
|
|
0.010 |
GeneticVariation
|
BEFREE |
The multivariable-adjusted odds ratios (ORs) (95% confidence intervals) for any history of migraine in the additive model were 1.0 (0.96-1.05) for rs1042713, 1.0 (0.95-1.05) for rs1042714, and 0.84 (0.68-1.05) for rs1800888.
|
18647184 |
2009 |
|
Juvenile arthritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genotypes and haplotypes of two ADRB2 variants (G16R and Q27E) were determined in 348 children with JIA and 448 healthy controls by direct molecular haplotyping using melting-curve analysis of a fluorescently labelled loci-spanning probe.
|
19177262 |
2009 |
|
Allergic sensitization
|
|
0.010 |
GeneticVariation
|
BEFREE |
The authors analyze the possible implication of 7 genetic polymorphisms described as asthma susceptibility genes: IL13 (C-1112T and R130Q), IL4RA (I50V, Q551R), IL5 (C-746T) and ADRB2 (Q27E and R16G) in specific olive pollen allergic sensitization.
|
18849614 |
2009 |
|
Chronic Kidney Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
The Chi-square test, multivariable logistic regression analysis with adjustment for covariates, and a stepwise forward selection procedure revealed that seven different polymorphisms were significantly (P<0.005) associated with the prevalence of CKD in individuals with low or high serum concentrations of TG or HDL- or LDL-cholesterol: the Aright curved arrow G (Glu23Lys) polymorphism of KCNJ11 and the 125592Cright curved arrow A (Thr431Asn) polymorphism of ROCK2 in individuals with low serum TG; the 734Cright curved arrow T (Thr254Ile) polymorphism of ACAT2 and the Cright curved arrow G (Gln27Glu) polymorphism of ADRB2 in individuals with high serum TG; the -1607/1Gright curved arrow 2G polymorphism of MMP1 in individuals with low serum HDL-cholesterol; the Gright curved arrow A (Val158Met) polymorphism of COMT in individuals with low serum LDL-cholesterol; the 584Gright curved arrow A (Gln192Arg) polymorphism of PON1 in individuals with high serum LDL-cholesterol.
|
19578796 |
2009 |
|
Graves Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our meta-analysis of the ADRB2 SNP rs1042714 measured heterogeneity between the ethnic groups (I2 = 53.1%) and no association to GD was observed in the overall three studies with a random effects model (OR = 1.13, 95% CI, 0.95 to 1.36; P = 0.18).
|
19284637 |
2009 |
|
ST segment elevation myocardial infarction
|
|
0.010 |
GeneticVariation
|
BEFREE |
For the ADRB2 Gln27Glu polymorphism, subjects having one or two copies of the Glu27 allele showed a decreased risk of MI compared with Gln27 homozygote subjects (OR=0.48, 95% CI=0.24-0.94, P=0.03).
|
19623647 |
2009 |
|
Intraocular pressure disorder
|
|
0.010 |
GeneticVariation
|
BEFREE |
After adjusting for sex, family history of glaucoma, and use of systemic beta-blockers, subjects with the CC genotype at coding single-nucleotide polymorphism rs1042714 in the ADRB2 gene were significantly more likely to experience an IOP decrease of 20% or more (odds ratio, 2.00; 95% confidence interval, 1.00-4.02).
|
18625943 |
2008 |
|
Ventricular arrhythmia
|
|
0.010 |
GeneticVariation
|
BEFREE |
beta1AR (Ser49Gly, Arg389Gly) and beta2AR (Gly16Arg, Gln27Glu) SNPs were genotyped in a case-control study comparing 107 patients with CAD and aborted SCD due to VA with 287 CAD control subjects and 101 healthy control subjects.
|
18534365 |
2008 |