|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We studied beta 2-adrenoceptor genotype for the Gln/Glu 27 polymorphism and airway reactivity in 65 patients with mild to moderate asthma.
|
7739309 |
1995 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The Gln27Glu polymorphism was markedly associated with obesity with a relative risk for obesity of approximately 7 and an odds ratio of approximately 10.
|
9399946 |
1997 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Asthmatics heterozygous for Gln/Glu27 had significantly later asthma onsets than those homozygous for Gln27.
|
10524541 |
1999 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
The different effects of a Gln27Glu beta 2-adrenoceptor gene polymorphism on obesity in males and in females.
|
10205587 |
1999 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Polymorphisms at amino acid positions 16 (arginine to glycine) and 27 (glutamine to glutamic acid) of the beta2-adrenoreceptor (B2AR) gene are known to be functionally relevant and have been associated with more severe forms of asthma, nocturnal asthma and decreased airway responsiveness in asthmatic subjects.
|
10469027 |
1999 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, we have found that in Japanese men the Gln27Glu beta2AR variant is associated with obesity due to subcutaneous fat accumulation.
|
10222249 |
1999 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Neither the Arg16Gly nor Gln27Glu polymorphisms showed evidence of linkage to qualitative measures of asthma and bronchial hyperresponsiveness (BHR) (p > 0.10) or to quantitative measures of serum IgE and airway reactivity (p > 0.10).
|
10934093 |
2000 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our results suggest that the Gln27Glu and Arg16Gly polymorphisms of the beta2AR gene are not a major contributing factor to obesity in Japanese men.
|
11016907 |
2000 |
|
Bronchial Hyperreactivity
|
|
0.010 |
GeneticVariation
|
BEFREE |
Neither the Arg16Gly nor Gln27Glu polymorphisms showed evidence of linkage to qualitative measures of asthma and bronchial hyperresponsiveness (BHR) (p > 0.10) or to quantitative measures of serum IgE and airway reactivity (p > 0.10).
|
10934093 |
2000 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate whether polymorphisms in the beta(2)-adrenergic receptor gene (5'LC-Arg19Cys, Arg16Gly, Gln27Glu) are associated with hypertension in patients with or without type 2 diabetes and with the blood pressure levels in normotensive sib pairs.
|
11358945 |
2001 |
|
Asthma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recent studies have suggested that two polymorphisms of the beta(2)-adrenergic receptor (beta(2)AR) gene at codons 16 (arginine to glycine) and 27 (glutamine to glutamate) affect an individual's airway responsiveness, or response to acute or chronic beta(2)-agonist therapy but are not risk factors for asthma.
|
11371409 |
2001 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, the Gln27Glu beta2-ADR variant is excluded in HT, but might influence body weight.
|
11775127 |
2001 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Even in Japanese-Americans, who have a more westernized life style than Japanese, the association of the beta(2)-AR gene (Gln27Glu) variant with the parameters of obesity, insulin resistance, and serum lipid level has yet to be clarified.
|
11288039 |
2001 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
There was no evidence of association between the C-47T and Glu27Gln polymorphisms and hypertension in this population.
|
11775126 |
2001 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.040 |
GeneticVariation
|
BEFREE |
The aim of this study was to investigate whether polymorphisms in the beta(2)-adrenergic receptor gene (5'LC-Arg19Cys, Arg16Gly, Gln27Glu) are associated with hypertension in patients with or without type 2 diabetes and with the blood pressure levels in normotensive sib pairs.
|
11358945 |
2001 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
|
0.040 |
GeneticVariation
|
BEFREE |
Common variants in the beta2-(Gln27Glu) and beta3-(Trp64Arg)--adrenoceptor genes are associated with elevated serum NEFA concentrations and type II diabetes.
|
11380082 |
2001 |
|
Hypertriglyceridemia
|
|
0.020 |
GeneticVariation
|
BEFREE |
Gln27Glu beta2-adrenergic receptor variant is associated with hypertriglyceridemia and the development of fatty liver.
|
11718682 |
2001 |
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Gln27Glu variant of the beta2-adrenergic receptor gene is not associated with obesity and diabetes in Japanese-Americans.
|
11288039 |
2001 |
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
In both males and females, there were no differences in the indices of obesity, insulin resistance, and serum lipid levels between the subjects with and without the beta(2)-AR gene (Gln27Glu) variant in patients with normal glucose tolerance (NGT), impaired glucose tolerance (IGT), or diabetes (DM).
|
11288039 |
2001 |
|
Steatohepatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Univariate analysis indicated that subjects with the heterozygous Gln27Glu mutant alleles had a significantly higher prevalence of fatty liver vs. those without the mutation (Glu27 allele frequency, 0.07 vs. 0.12, p=0.047; odds ratio, 1.92; 95% confidence interval, 1.01-3.68).
|
11718682 |
2001 |
|
Fatty Liver
|
|
0.010 |
GeneticVariation
|
BEFREE |
Univariate analysis indicated that subjects with the heterozygous Gln27Glu mutant alleles had a significantly higher prevalence of fatty liver vs. those without the mutation (Glu27 allele frequency, 0.07 vs. 0.12, p=0.047; odds ratio, 1.92; 95% confidence interval, 1.01-3.68).
|
11718682 |
2001 |
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
We conclude that the beta(2)-AR gene (Gln27Glu) variant might not be an important factor for obesity or IGT in Japanese subjects.
|
11288039 |
2001 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
Additionally, for the polymorphic sites of BAR-2 (Arg16Gly and Gln27Glu) a significant effect on obesity risk was seen.
|
12395215 |
2002 |
|
Obesity
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results provide evidence about a possible impact of the Gln27Glu polymorphism in the ADRB2 gene concerning a better response to exercise in obese Gln27 female subjects, in which basal insulinemia may play a role.
|
12435085 |
2002 |
|
Hypertensive disease
|
|
0.100 |
GeneticVariation
|
BEFREE |
Four ADRB2 gene polymorphisms C19R (T-47C), T-20C, G16R (G+46A), Q27E (C+79G) were investigated in two studies: PEGASE, a study of moderate to severe hypertension (707 cases) conducted in France, and ECTIM, a case-control study of MI (1178 cases, 1187 controls) conducted in France, Northern Ireland and Scotland.
|
11821707 |
2002 |