|
Nasopharyngeal carcinoma
|
|
0.700 |
GeneticVariation
|
GWASDB |
A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.
|
20512145 |
2010 |
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant interactions were observed between alcohol and ADH1b (rs1229984) with respect to LDL and between alcohol and ALDH2 (rs886205) with respect to IGT/diabetes.
|
20700531 |
2010 |
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant interactions were observed between alcohol and ADH1b (rs1229984) with respect to LDL and between alcohol and ALDH2 (rs886205) with respect to IGT/diabetes.
|
20700531 |
2010 |
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant interactions were observed between alcohol and ADH1b (rs1229984) with respect to LDL and between alcohol and ALDH2 (rs886205) with respect to IGT/diabetes.
|
20700531 |
2010 |
|
Esophageal Neoplasms
|
|
0.840 |
GeneticVariation
|
GWASDB |
Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles.
|
20833657 |
2010 |
|
Squamous cell carcinoma of esophagus
|
|
0.080 |
GeneticVariation
|
BEFREE |
By integrating both genetic and environmental risk factors, it was shown that the combination of rs1229984 and rs671 risk alleles with smoking and alcohol consumption was associated with OSCC.
|
20833657 |
2010 |
|
Esophageal Neoplasms
|
|
0.840 |
GeneticVariation
|
BEFREE |
ADH1B Arg47His polymorphism is associated with esophageal cancer risk in high-incidence Asian population: evidence from a meta-analysis.
|
21048924 |
2010 |
|
Malignant neoplasm of esophagus
|
|
0.750 |
GeneticVariation
|
BEFREE |
ADH1B Arg47His polymorphism is associated with esophageal cancer risk in high-incidence Asian population: evidence from a meta-analysis.
|
21048924 |
2010 |
|
Squamous cell carcinoma of esophagus
|
|
0.080 |
GeneticVariation
|
BEFREE |
A dataset composed of 4,220 cases and 8,946 controls from twelve studies of Asian populations was analyzed for ADH1B Arg47His association with ESCC and its interactions with alcohol drinking and ALDH2 Glu504Lys.
|
21048924 |
2010 |
|
Esophageal carcinoma
|
|
0.040 |
GeneticVariation
|
BEFREE |
ADH1B Arg47His polymorphism is associated with esophageal cancer risk in high-incidence Asian population: evidence from a meta-analysis.
|
21048924 |
2010 |
|
Squamous cell carcinoma of esophagus
|
|
0.080 |
GeneticVariation
|
BEFREE |
The genetic variations of ADH1B His47Arg and ALDH2 Glu487Lys are susceptible loci for ESCC in Chinese Han population and interact substantially with alcohol consumption.
|
21157980 |
2010 |
|
Carcinoma of larynx
|
|
0.010 |
GeneticVariation
|
BEFREE |
Alcohol-dehydrogenase (ADH1B) Arg48His polymorphism in Basque Country patients with oral and laryngeal cancer: preliminary study.
|
21378355 |
2011 |
|
Laryngeal Squamous Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to determine the distribution of alcohol dehydrogenase-1B polymorphism (Arg48His; rs1229984) in our region and analyze its association with the risk of oral and laryngeal squamous cell carcinoma.
|
21378355 |
2011 |
|
Malignant neoplasm of larynx
|
|
0.010 |
GeneticVariation
|
BEFREE |
Alcohol-dehydrogenase (ADH1B) Arg48His polymorphism in Basque Country patients with oral and laryngeal cancer: preliminary study.
|
21378355 |
2011 |
|
Head and Neck Neoplasms
|
|
0.800 |
GeneticVariation
|
GWASCAT |
A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.
|
21437268 |
2011 |
|
Head and Neck Neoplasms
|
|
0.800 |
GeneticVariation
|
GWASDB |
A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.
|
21437268 |
2011 |
|
Drug Dependence
|
|
0.010 |
GeneticVariation
|
BEFREE |
A variant of the ADH1B gene (rs1229984 or Arg48His; previously referred to as Arg [*1] and His [*1]) has been reported to be associated with reduced rates of alcohol and drug dependence.
|
21497796 |
2011 |
|
Substance Dependence
|
|
0.010 |
GeneticVariation
|
BEFREE |
Different studies have produced inconclusive results regarding association between rs1229984 (or rs2066702) and substance dependence.
|
21497796 |
2011 |
|
Adenoma of large intestine
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, the present study suggested that the ADH1B Arg47His polymorphism does not contribute to the risk of colorectal adenoma in any subgroup of middle-aged Japanese men defined by alcohol drinking, as well as the ALDH2 Glu487Lys and MTHFR C677T genotypes.
|
21517275 |
2011 |
|
Primary malignant neoplasm
|
|
0.050 |
GeneticVariation
|
BEFREE |
Stratified analyses were carried out to determine the gene-environment interaction between ADH1B His47Arg and alcohol drinking and gene-gene interaction between ADH1B His47Arg and aldehyde dehydrogenase-2 (ALDH2) Glu/Lys related to UADT cancer risk.
|
21895720 |
2012 |
|
Malignant Neoplasms
|
|
0.050 |
GeneticVariation
|
BEFREE |
Stratified analyses were carried out to determine the gene-environment interaction between ADH1B His47Arg and alcohol drinking and gene-gene interaction between ADH1B His47Arg and aldehyde dehydrogenase-2 (ALDH2) Glu/Lys related to UADT cancer risk.
|
21895720 |
2012 |
|
Malignant Neoplasms
|
|
0.050 |
GeneticVariation
|
BEFREE |
Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]).
|
21917409 |
2012 |
|
Primary malignant neoplasm
|
|
0.050 |
GeneticVariation
|
BEFREE |
Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]).
|
21917409 |
2012 |
|
Alcohol abuse
|
|
0.030 |
GeneticVariation
|
BEFREE |
Among conventional markers of alcohol abuse, the mean corpuscular volume (MCV) of erythrocytes is prognostic of alcohol-related cancer and its predictivity increases when combined with functional polymorphisms of alcohol dehydrogenase (ADH1B [rs1229984] and ADH1C [rs698]) and the mitochondrial aldehyde dehydrogenase (ALDH2 [rs671]).
|
21917409 |
2012 |
|
Squamous cell carcinoma of the head and neck
|
|
0.030 |
GeneticVariation
|
BEFREE |
Two SNPs were associated with SCCHN risk: ADH1B rs1229984 A allele (OR = 0.7; 95% CI, 0.6-0.9) and ALDH2 rs2238151 C allele (OR = 1.2; 95% CI, 1.1-1.4).
|
21940907 |
2011 |