|
Impaired cognition
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs1229984 G→A polymorphism did not decrease the odds of cognitive impairment (AA/GG OR = 1.35, 95% CI = 0.29-6.27; GA/GG OR = 1.05, 95% CI = 0.71-1.55).
|
24553426 |
2014 |
|
Depressed mood
|
|
0.010 |
GeneticVariation
|
BEFREE |
The ADH1B rs1229984 G-->A polymorphism was not associated with current or past depression (P=0.857).
|
24018899 |
2014 |
|
Carcinoma of larynx
|
|
0.010 |
GeneticVariation
|
BEFREE |
Alcohol-dehydrogenase (ADH1B) Arg48His polymorphism in Basque Country patients with oral and laryngeal cancer: preliminary study.
|
21378355 |
2011 |
|
Laryngeal Squamous Cell Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The aim of this study was to determine the distribution of alcohol dehydrogenase-1B polymorphism (Arg48His; rs1229984) in our region and analyze its association with the risk of oral and laryngeal squamous cell carcinoma.
|
21378355 |
2011 |
|
Drug Dependence
|
|
0.010 |
GeneticVariation
|
BEFREE |
A variant of the ADH1B gene (rs1229984 or Arg48His; previously referred to as Arg [*1] and His [*1]) has been reported to be associated with reduced rates of alcohol and drug dependence.
|
21497796 |
2011 |
|
Substance Dependence
|
|
0.010 |
GeneticVariation
|
BEFREE |
Different studies have produced inconclusive results regarding association between rs1229984 (or rs2066702) and substance dependence.
|
21497796 |
2011 |
|
Malignant neoplasm of larynx
|
|
0.010 |
GeneticVariation
|
BEFREE |
Alcohol-dehydrogenase (ADH1B) Arg48His polymorphism in Basque Country patients with oral and laryngeal cancer: preliminary study.
|
21378355 |
2011 |
|
Adenoma of large intestine
|
|
0.010 |
GeneticVariation
|
BEFREE |
In conclusion, the present study suggested that the ADH1B Arg47His polymorphism does not contribute to the risk of colorectal adenoma in any subgroup of middle-aged Japanese men defined by alcohol drinking, as well as the ALDH2 Glu487Lys and MTHFR C677T genotypes.
|
21517275 |
2011 |
|
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant interactions were observed between alcohol and ADH1b (rs1229984) with respect to LDL and between alcohol and ALDH2 (rs886205) with respect to IGT/diabetes.
|
20700531 |
2010 |
|
Impaired glucose tolerance
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant interactions were observed between alcohol and ADH1b (rs1229984) with respect to LDL and between alcohol and ALDH2 (rs886205) with respect to IGT/diabetes.
|
20700531 |
2010 |
|
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant interactions were observed between alcohol and ADH1b (rs1229984) with respect to LDL and between alcohol and ALDH2 (rs886205) with respect to IGT/diabetes.
|
20700531 |
2010 |
|
Flushing
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results bridge the gap between DNA sequence variation and alcohol-related behavior, confirming that the ADH1B-Arg48His polymorphism affects both alcohol-related flushing in Europeans and alcohol intake.
|
18996923 |
2009 |
|
Premature coronary artery atherosclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Joint effects of eNOS gene T-786C and ADH2 Arg47His polymorphisms on the risk of premature coronary artery disease.
|
17289126 |
2007 |
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The mutant genotypes of eNOS gene T-786C mutation and the fast form of ADH2 Arg47His polymorphism had an additive interaction on the risk of premature CAD in Chinese population.
|
17289126 |
2007 |
|
Carcinogenesis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Arg47His (rs1229984 G > A) in <i>ADH1B</i> have been frequently studied for its potential effect on carcinogenesis.
|
30872408 |
2019 |
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, no significant relationship was measured between ADH1B Arg47His and gastric cancer risk.
|
28002588 |
2016 |
|
Malignant neoplasm of stomach
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, no significant relationship was measured between ADH1B Arg47His and gastric cancer risk.
|
28002588 |
2016 |
|
Malignant neoplasm of colon and/or rectum
|
|
0.020 |
GeneticVariation
|
BEFREE |
Association of ADH1B Arg47His and ALDH2 Glu487Lys polymorphisms with risk of colorectal cancer and their interaction with environmental factors in a Chinese population.
|
27706775 |
2016 |
|
Mental disorders
|
|
0.020 |
GeneticVariation
|
BEFREE |
We investigated the relationship of ADH1B rs1229984 and ALDH2 rs671 polymorphism combinations with mental disorder risks.
|
25543168 |
2015 |
|
Mental disorders
|
|
0.020 |
GeneticVariation
|
BEFREE |
We also tested whether the association between rs1229984 and each of the 11 Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV), AUD criteria occurs through consumption.
|
24988262 |
2014 |
|
Stomach Carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
A known functional SNP in ADH1B (rs1229984) was associated with alcohol intake (P-value = 0.04) but not GC risk.
|
22144473 |
2012 |
|
Malignant neoplasm of stomach
|
|
0.020 |
GeneticVariation
|
BEFREE |
A known functional SNP in ADH1B (rs1229984) was associated with alcohol intake (P-value = 0.04) but not GC risk.
|
22144473 |
2012 |
|
Malignant neoplasm of pancreas
|
|
0.020 |
GeneticVariation
|
BEFREE |
Based on the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, we studied the association of polymorphisms in the tobacco carcinogen-metabolizing gene CYP2A13 (Arg101Stop) and the alcohol-metabolizing genes ADH1B (Arg48His) and ADH1C (Ile350Val) with pancreatic cancer risk.
|
19812523 |
2010 |
|
Pancreatic carcinoma
|
|
0.020 |
GeneticVariation
|
BEFREE |
Based on the assumption that genetic variation in carcinogen metabolism further modifies the risk of exposure-related cancers, we studied the association of polymorphisms in the tobacco carcinogen-metabolizing gene CYP2A13 (Arg101Stop) and the alcohol-metabolizing genes ADH1B (Arg48His) and ADH1C (Ile350Val) with pancreatic cancer risk.
|
19812523 |
2010 |
|
Malignant neoplasm of pancreas
|
|
0.020 |
GeneticVariation
|
BEFREE |
The impact of alcohol and polymorphisms in aldehyde dehydrogenase 2 (ALDH2) Glu504Lys, alcohol dehydrogenase (ADH) 1B His48Arg, and ADH1C Arg272Gln on PC risk was examined with multivariate analysis adjusted for potential confounders to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
|
19068087 |
2009 |