|
Esophageal Neoplasms
|
|
0.840 |
GeneticVariation
|
GWASDB |
Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles.
|
20833657 |
2010 |
|
Esophageal Neoplasms
|
|
0.840 |
GeneticVariation
|
BEFREE |
ADH1B Arg47His polymorphism is associated with esophageal cancer risk in high-incidence Asian population: evidence from a meta-analysis.
|
21048924 |
2010 |
|
Esophageal Neoplasms
|
|
0.840 |
GeneticVariation
|
GWASCAT |
Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk.
|
19698717 |
2009 |
|
Alcohol consumption
|
|
0.800 |
GeneticVariation
|
GWASCAT |
We also observed a genome-wide significant association in non-Hispanic whites between the previously reported SNP rs1229984 in ADH1B and both alcohol consumption phenotypes (OR=0.79, P=2.47 × 10<sup>-20</sup> for drinker status and beta=-0.19, P=1.91 × 10<sup>-35</sup> for drinks/week), which replicated in Hispanic/Latinos (OR=0.72, P=4.35 × 10<sup>-7</sup> and beta=-0.21, P=2.58 × 10<sup>-6</sup>, respectively).
|
28485404 |
2017 |
|
Alcohol consumption
|
|
0.800 |
GeneticVariation
|
GWASCAT |
A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.
|
23743675 |
2013 |
|
Alcohol consumption
|
|
0.800 |
GeneticVariation
|
GWASDB |
A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.
|
23743675 |
2013 |
|
Head and Neck Neoplasms
|
|
0.800 |
GeneticVariation
|
GWASCAT |
A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.
|
21437268 |
2011 |
|
Head and Neck Neoplasms
|
|
0.800 |
GeneticVariation
|
GWASDB |
A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.
|
21437268 |
2011 |
|
Malignant neoplasm of esophagus
|
|
0.750 |
GeneticVariation
|
BEFREE |
Our results suggested that ADH1B gene Arg47His variant was associated with the decreased esophageal cancer risk.
|
27450204 |
2016 |
|
Malignant neoplasm of esophagus
|
|
0.750 |
GeneticVariation
|
BEFREE |
ADH1B rs1229984 polymorphism HRs for HNC and oesophageal cancer death and for alcohol related cancer death were 0.67 (95% CI: 0.42-1.08), and 0.64 (95% CI: 0.40-1.03), respectively.
|
25770642 |
2015 |
|
Malignant neoplasm of esophagus
|
|
0.750 |
GeneticVariation
|
BEFREE |
The functional polymorphisms ADH1B rs1229984 may contribute to susceptibility to esophageal cancer.
|
24093763 |
2014 |
|
Malignant neoplasm of esophagus
|
|
0.750 |
GeneticVariation
|
BEFREE |
In conclusion, our findings indicated that ADH1B (rs1229984) was associated with EC independent of alcohol drinking and tobacco smoking status and alcohol drinking interacted with ALDH2 (rs671) on EC susceptibility in this high-risk Chinese population.
|
22930414 |
2013 |
|
Malignant neoplasm of esophagus
|
|
0.750 |
GeneticVariation
|
BEFREE |
ADH1B Arg47His polymorphism is associated with esophageal cancer risk in high-incidence Asian population: evidence from a meta-analysis.
|
21048924 |
2010 |
|
Malignant neoplasm of esophagus
|
|
0.750 |
GeneticVariation
|
GWASDB |
Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk.
|
19698717 |
2009 |
|
Cardiovascular Diseases
|
|
0.710 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Cardiovascular Diseases
|
|
0.710 |
GeneticVariation
|
BEFREE |
To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as an instrument to investigate the causal role of alcohol in cardiovascular disease.
|
25011450 |
2014 |
|
Alcohol-Related Disorders
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association studies of alcohol dependence, DSM-IV criterion count and individual criteria.
|
31090166 |
2019 |
|
Alcohol-Induced Disorders
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.
|
30940813 |
2019 |
|
Alcohol-Induced Disorders
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association studies of alcohol dependence, DSM-IV criterion count and individual criteria.
|
31090166 |
2019 |
|
Red Blood Cell Count measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Finding of Mean Corpuscular Hemoglobin
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Sodium measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits.
|
31409800 |
2019 |
|
Body mass index
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Alcohol-Related Disorders
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.
|
30940813 |
2019 |
|
Blood urea nitrogen measurement
|
|
0.700 |
GeneticVariation
|
GWASCAT |
A catalog of genetic loci associated with kidney function from analyses of a million individuals.
|
31152163 |
2019 |