Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
Association of CDKN2BAS polymorphism rs4977574 with coronary heart disease: a case-control study and a meta-analysis.
|
25268619 |
2014 |
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
GWASDB |
Genomewide association analysis of coronary artery disease.
|
17634449 |
2007 |
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies a missense variant at APOA5 for coronary artery disease in Multi-Ethnic Cohorts from Southeast Asia.
|
29263402 |
2017 |
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
CAD association was replicated for three GWAS-identified loci (1p13.3/SORT1 (rs599839), 9p21.3/CDKN2A/2B (rs4977574), and 11q22.3/ PDGFD (rs974819)) in Koreans.
|
23364394 |
2013 |
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
Our findings suggest that the GG genotype of the CDKN2B-AS1 gene variant rs4977574, which has been previously associated with an increased CAD risk, is also associated with a decreased susceptibility to the development of hypertension.
|
29791233 |
2018 |
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
The rs4977574 with G allele may confer to a higher risk of CAD, especially MI.
|
30278588 |
2018 |
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
The rs4977574</span> at chromosome 9p21 is associated with presence of CAD in Han Chinese.
|
24804228 |
2014 |
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
Association of rs4977574 with severity of CA</span>D was confirmed in the Canadian Study.
|
23343465 |
2013 |
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
The presence of rs4977574 G and rs1333040 T alleles and interaction may exist as environmental factors associated with lipid metabolism and might be responsible for the development of CAD in a Turkish Cypriot population.
|
30587704 |
2019 |
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
Four SNPs, rs4977574_A [0.56(0.50-0.63); p < 0.0001], rs10757274_A [0.87(0.77-0.97); p = 0.014], rs10738607_A [0.89(0.80-1.00); p = 0.043] and rs1333045_T [0.54(0.48-0.61); p < 0.0001] residing on the CDKN2B gene were significantly associated with CAD following multivariate adjustments for MI, HTN and DM, while four others were weakly associated with the disease.
|
29894795 |
2018 |
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
GWASCAT |
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
|
29212778 |
2018 |
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
Besides the CAD/MI SNP at 9p21 (rs4977574, P = 3.1 × 10(-10)), two additional loci at ADAMTS7 (rs3825807, P = 6.5 × 10(-6)) and at PHACTR1 (rs12526453, P = 1.0 × 10(-3)) show a nominally significant association with coronary artery calcification with MI/CAD risk alleles increasing the degree of arterial calcification.
|
23561647 |
2013 |
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
BEFREE |
One marker, rs6922269, in MTHFD1L was significantly protective against MI (OR=0.68, p=0.0035), while the variant rs4977574 in CDKN2A-CDKN2B was significantly associated with MI (OR=1.33, p=0.0086).
|
22216278 |
2011 |
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
GWASCAT |
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.
|
19198609 |
2009 |
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
BEFREE |
Comparisons of allele frequencies by the χ(2) test revealed that rs9369640 of the phosphatase and actin regulator 1 gene (PHACTR1, FDR=0.0007), rs4977574 of the CDKN2B antisense RNA 1 gene (CDKN2B-AS1, FDR=0.0038), rs264 of the lipoprotein lipase gene (LPL, FDR=0.0061), rs599839 of the proline/serine-rich coiled-coil 1 gene (PSRC1, FDR=0.0118), rs9319428 of the fms-related tyrosine kinase 1 gene (FLT1, FDR=0.0118) and rs12413409 of the cyclin and CBS domain divalent metal cation transport mediator 2 gene (CNNM2, FDR=0.0300) were significantly associated with MI.
|
25738804 |
2015 |
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
BEFREE |
Four SNPs, rs4977574_A [0.56(0.50-0.63); p < 0.0001], rs10757274_A [0.87(0.77-0.97); p = 0.014], rs10738607_A [0.89(0.80-1.00); p = 0.043] and rs1333045_T [0.54(0.48-0.61); p < 0.0001] residing on the CDKN2B gene were significantly associated with CAD following multivariate adjustments for MI, HTN and DM, while four others were weakly associated with the disease.
|
29894795 |
2018 |
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
BEFREE |
The rs4977574 with G allele may confer to a higher risk of CAD, especially MI.
|
30278588 |
2018 |
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
BEFREE |
Besides the CAD/MI SNP at 9p21 (rs4977574, P = 3.1 × 10(-10)), two additional loci at ADAMTS7 (rs3825807, P = 6.5 × 10(-6)) and at PHACTR1 (rs12526453, P = 1.0 × 10(-3)) show a nominally significant association with coronary artery calcification with MI/CAD risk alleles increasing the degree of arterial calcification.
|
23561647 |
2013 |
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
GWASDB |
A common variant on chromosome 9p21 affects the risk of myocardial infarction.
|
17478679 |
2007 |
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
BEFREE |
PCR-RFLP revealed that the frequency of rs4977574, the MI-associated allele (G), was 56.8% (25/44) in patients with MI and 33.9% (9.5/28) in controls; the frequency of rs4977574 in patients with MI was significantly higher compared to controls (P = 0.027).
|
23856978 |
2013 |
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
GWASDB |
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.
|
19198609 |
2009 |
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
BEFREE |
We showed a significant interaction between SSB intake and one of the 3 variants (i.e., rs4977574) on MI risk.
|
26961926 |
2016 |
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
BEFREE |
After age, sex, and BMI adjustment, we observed the SNPs rs12190287, rs12413409, rs1412444, rs1746048 and rs4977574, were significantly associated with MI in additive models and rs12190287, rs12413409, rs4977574 were significantly associated with phenotypes of MI at the same time.
|
24475106 |
2014 |
Coronary heart disease
|
|
0.840 |
GeneticVariation
|
GWASCAT |
Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies.
|
21239051 |
2011 |
Coronary heart disease
|
|
0.840 |
GeneticVariation
|
GWASDB |
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.
|
21378988 |
2011 |