|
Acute Chest Syndrome
|
|
0.030 |
GeneticVariation
|
BEFREE |
The hazard ratio associated with the high-risk genotype (a homozygote of high risk for ACS or a heterozygote) was: HR = 2.2 (1.15-4.2) for the rs10757278 polymorphism, HR = 2.7 (95% CI 1.3-5.4) for the rs4977574 one and HR = 2.3 (1.2-4.5) for the rs1333049 one (Cox proportional hazards model).
|
25105296 |
2014 |
|
Acute Chest Syndrome
|
|
0.030 |
GeneticVariation
|
BEFREE |
The rs1333049, rs10757278 and rs4977574 are single nucleotide polymorphisms (SNPs) of chromosome 9p21 locus that are associated with prevalence of acute coronary syndromes (ACS).
|
24069144 |
2013 |
|
Acute Chest Syndrome
|
|
0.030 |
GeneticVariation
|
BEFREE |
An interaction for increased ACS risk was found between carriers of the chromosome 9p21 variant rs4977574 and low omega-3 index (OR 1.57, 95% CI 1.07-2.32, p = 0.02), but this was not significant after correction for multiple testing.
|
24998078 |
2014 |
|
Acute Coronary Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
The rs10757278, rs1333049 and rs4977574 are single nucleotide polymorphisms (SNPs) of chromosome 9p21 locus associated with a prevalence of acute coronary syndromes (ACS).
|
25105296 |
2014 |
|
Acute Coronary Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
The rs1333049, rs10757278 and rs4977574 are single nucleotide polymorphisms (SNPs) of chromosome 9p21 locus that are associated with prevalence of acute coronary syndromes (ACS).
|
24069144 |
2013 |
|
Angina Pectoris
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this follow-up study, rs4977574, a tag SNP at chromosome 9p21, was shown to be associated with cardiovascular mortality in Taiwanese patients with angina pectoris but no coronary lesions.
|
26426617 |
2015 |
|
Brain Ischemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs4977574 and rs7857345 polymorphisms in patients with carotid artery stenosis appear to affect a person's susceptibility to atherogenic brain ischemia.
|
31824394 |
2019 |
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In addi- tion, among all observed haplotypes (with SNP order of rs1333045, rs1333048 rs4977574 and rs10757278), four haplotypes were shown to be associated with breast cancer risk.
|
28580310 |
2017 |
|
Calcification of coronary artery
|
|
0.700 |
GeneticVariation
|
GWASDB |
Candidate gene association study of coronary artery calcification in chronic kidney disease: findings from the CRIC study (Chronic Renal Insufficiency Cohort).
|
23727086 |
2013 |
|
Calcification of coronary artery
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction.
|
22144573 |
2011 |
|
Cardiovascular Diseases
|
|
0.030 |
GeneticVariation
|
BEFREE |
rs4977574 on chromosome 9p21 was genotyped in 24 777 subjects from the Malmö Diet and Cancer study who were free from CVD prior to the baseline examination.
|
23480785 |
2013 |
|
Cardiovascular Diseases
|
|
0.030 |
GeneticVariation
|
BEFREE |
Neither education nor physical activity-leve</span>ls modified the associated risk of CAD, ischemic stroke and CVD mortality conferred by rs4977574.
|
24465769 |
2014 |
|
Cardiovascular Diseases
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our results indicate that rs4977574 interacts with vegetable and wine intake to affect the incidence of CVD, and suggest that an interaction may exist between environmental risk factors and rs4977574 on known risk markers of CVD.
|
25551366 |
2014 |
|
Carotid Stenosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
<b>Conclusions:</b> The present research on the carotid artery stenosis patient cohort suggests the significant association between the rs4977574, rs7857345 and rs3798220 polymorphisms and carotid artery stenosis as well as between the rs4977574 and rs7857345 polymorphisms and atherogenic stroke.
|
31824394 |
2019 |
|
Coronary Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Association of CDKN2BAS polymorphism rs4977574 with coronary heart disease: a case-control study and a meta-analysis.
|
25268619 |
2014 |
|
Coronary Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
ANRIL polymorphism rs4977574 is associated with increased risk of coronary artery disease in Asian populations: A meta-analysis of 12,005 subjects.
|
30278588 |
2018 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
Association of CDKN2BAS polymorphism rs4977574 with coronary heart disease: a case-control study and a meta-analysis.
|
25268619 |
2014 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
GWASDB |
Genomewide association analysis of coronary artery disease.
|
17634449 |
2007 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies a missense variant at APOA5 for coronary artery disease in Multi-Ethnic Cohorts from Southeast Asia.
|
29263402 |
2017 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
CAD association was replicated for three GWAS-identified loci (1p13.3/SORT1 (rs599839), 9p21.3/CDKN2A/2B (rs4977574), and 11q22.3/ PDGFD (rs974819)) in Koreans.
|
23364394 |
2013 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
Our findings suggest that the GG genotype of the CDKN2B-AS1 gene variant rs4977574, which has been previously associated with an increased CAD risk, is also associated with a decreased susceptibility to the development of hypertension.
|
29791233 |
2018 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
The rs4977574 with G allele may confer to a higher risk of CAD, especially MI.
|
30278588 |
2018 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
The rs4977574</span> at chromosome 9p21 is associated with presence of CAD in Han Chinese.
|
24804228 |
2014 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
Association of rs4977574 with severity of CA</span>D was confirmed in the Canadian Study.
|
23343465 |
2013 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
The presence of rs4977574 G and rs1333040 T alleles and interaction may exist as environmental factors associated with lipid metabolism and might be responsible for the development of CAD in a Turkish Cypriot population.
|
30587704 |
2019 |