|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
Association of CDKN2BAS polymorphism rs4977574 with coronary heart disease: a case-control study and a meta-analysis.
|
25268619 |
2014 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
CAD association was replicated for three GWAS-identified loci (1p13.3/SORT1 (rs599839), 9p21.3/CDKN2A/2B (rs4977574), and 11q22.3/ PDGFD (rs974819)) in Koreans.
|
23364394 |
2013 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
Our findings suggest that the GG genotype of the CDKN2B-AS1 gene variant rs4977574, which has been previously associated with an increased CAD risk, is also associated with a decreased susceptibility to the development of hypertension.
|
29791233 |
2018 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
The rs4977574 with G allele may confer to a higher risk of CAD, especially MI.
|
30278588 |
2018 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
The rs4977574</span> at chromosome 9p21 is associated with presence of CAD in Han Chinese.
|
24804228 |
2014 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
Association of rs4977574 with severity of CA</span>D was confirmed in the Canadian Study.
|
23343465 |
2013 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
The presence of rs4977574 G and rs1333040 T alleles and interaction may exist as environmental factors associated with lipid metabolism and might be responsible for the development of CAD in a Turkish Cypriot population.
|
30587704 |
2019 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
Four SNPs, rs4977574_A [0.56(0.50-0.63); p < 0.0001], rs10757274_A [0.87(0.77-0.97); p = 0.014], rs10738607_A [0.89(0.80-1.00); p = 0.043] and rs1333045_T [0.54(0.48-0.61); p < 0.0001] residing on the CDKN2B gene were significantly associated with CAD following multivariate adjustments for MI, HTN and DM, while four others were weakly associated with the disease.
|
29894795 |
2018 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
Besides the CAD/MI SNP at 9p21 (rs4977574, P = 3.1 × 10(-10)), two additional loci at ADAMTS7 (rs3825807, P = 6.5 × 10(-6)) and at PHACTR1 (rs12526453, P = 1.0 × 10(-3)) show a nominally significant association with coronary artery calcification with MI/CAD risk alleles increasing the degree of arterial calcification.
|
23561647 |
2013 |
|
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
BEFREE |
One marker, rs6922269, in MTHFD1L was significantly protective against MI (OR=0.68, p=0.0035), while the variant rs4977574 in CDKN2A-CDKN2B was significantly associated with MI (OR=1.33, p=0.0086).
|
22216278 |
2011 |
|
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
BEFREE |
Comparisons of allele frequencies by the χ(2) test revealed that rs9369640 of the phosphatase and actin regulator 1 gene (PHACTR1, FDR=0.0007), rs4977574 of the CDKN2B antisense RNA 1 gene (CDKN2B-AS1, FDR=0.0038), rs264 of the lipoprotein lipase gene (LPL, FDR=0.0061), rs599839 of the proline/serine-rich coiled-coil 1 gene (PSRC1, FDR=0.0118), rs9319428 of the fms-related tyrosine kinase 1 gene (FLT1, FDR=0.0118) and rs12413409 of the cyclin and CBS domain divalent metal cation transport mediator 2 gene (CNNM2, FDR=0.0300) were significantly associated with MI.
|
25738804 |
2015 |
|
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
BEFREE |
Four SNPs, rs4977574_A [0.56(0.50-0.63); p < 0.0001], rs10757274_A [0.87(0.77-0.97); p = 0.014], rs10738607_A [0.89(0.80-1.00); p = 0.043] and rs1333045_T [0.54(0.48-0.61); p < 0.0001] residing on the CDKN2B gene were significantly associated with CAD following multivariate adjustments for MI, HTN and DM, while four others were weakly associated with the disease.
|
29894795 |
2018 |
|
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
BEFREE |
The rs4977574 with G allele may confer to a higher risk of CAD, especially MI.
|
30278588 |
2018 |
|
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
BEFREE |
Besides the CAD/MI SNP at 9p21 (rs4977574, P = 3.1 × 10(-10)), two additional loci at ADAMTS7 (rs3825807, P = 6.5 × 10(-6)) and at PHACTR1 (rs12526453, P = 1.0 × 10(-3)) show a nominally significant association with coronary artery calcification with MI/CAD risk alleles increasing the degree of arterial calcification.
|
23561647 |
2013 |
|
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
BEFREE |
PCR-RFLP revealed that the frequency of rs4977574, the MI-associated allele (G), was 56.8% (25/44) in patients with MI and 33.9% (9.5/28) in controls; the frequency of rs4977574 in patients with MI was significantly higher compared to controls (P = 0.027).
|
23856978 |
2013 |
|
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
BEFREE |
We showed a significant interaction between SSB intake and one of the 3 variants (i.e., rs4977574) on MI risk.
|
26961926 |
2016 |
|
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
BEFREE |
After age, sex, and BMI adjustment, we observed the SNPs rs12190287, rs12413409, rs1412444, rs1746048 and rs4977574, were significantly associated with MI in additive models and rs12190287, rs12413409, rs4977574 were significantly associated with phenotypes of MI at the same time.
|
24475106 |
2014 |
|
Coronary heart disease
|
|
0.840 |
GeneticVariation
|
BEFREE |
Meta-analysis of 23 studies among 36,452 cases and 39,781 controls showed a strong association between rs4977574 and the risk of CHD (p<0.0001, OR=1.27, 95% CI=1.22-1.31).
|
25268619 |
2014 |
|
Coronary heart disease
|
|
0.840 |
GeneticVariation
|
BEFREE |
The frequencies of the rs4977574 genotypes and alleles between CHD and control groups, and the rs2740483 genotypes and alleles between IS and control groups were different (p = 0.006-0.001).
|
27096864 |
2016 |
|
Coronary heart disease
|
|
0.840 |
GeneticVariation
|
BEFREE |
ANRIL polymorphism rs4977574 is associated with increased risk of coronary artery disease in Asian populations: A meta-analysis of 12,005 subjects.
|
30278588 |
2018 |
|
Coronary heart disease
|
|
0.840 |
GeneticVariation
|
BEFREE |
Five single-nucleotide polymorphisms, rs4977574 (CDKN2A/2B), rs12526453 (PHACTR1), rs646776 (CELSR2-PSRC1-SORT1), rs2259816 (HNF1A), and rs11206510 (PCSK9) showed directionally consistent associations with CHD in the 3 studies, with combined odds ratios (ORs) ranging from 1.17 to 1.25 (p = 0.03 to 0.0002).
|
22152955 |
2011 |
|
Cardiovascular Diseases
|
|
0.030 |
GeneticVariation
|
BEFREE |
rs4977574 on chromosome 9p21 was genotyped in 24 777 subjects from the Malmö Diet and Cancer study who were free from CVD prior to the baseline examination.
|
23480785 |
2013 |
|
Cardiovascular Diseases
|
|
0.030 |
GeneticVariation
|
BEFREE |
Neither education nor physical activity-leve</span>ls modified the associated risk of CAD, ischemic stroke and CVD mortality conferred by rs4977574.
|
24465769 |
2014 |
|
Acute Chest Syndrome
|
|
0.030 |
GeneticVariation
|
BEFREE |
The hazard ratio associated with the high-risk genotype (a homozygote of high risk for ACS or a heterozygote) was: HR = 2.2 (1.15-4.2) for the rs10757278 polymorphism, HR = 2.7 (95% CI 1.3-5.4) for the rs4977574 one and HR = 2.3 (1.2-4.5) for the rs1333049 one (Cox proportional hazards model).
|
25105296 |
2014 |
|
Acute Chest Syndrome
|
|
0.030 |
GeneticVariation
|
BEFREE |
The rs1333049, rs10757278 and rs4977574 are single nucleotide polymorphisms (SNPs) of chromosome 9p21 locus that are associated with prevalence of acute coronary syndromes (ACS).
|
24069144 |
2013 |