|
Carotid Stenosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
<b>Conclusions:</b> The present research on the carotid artery stenosis patient cohort suggests the significant association between the rs4977574, rs7857345 and rs3798220 polymorphisms and carotid artery stenosis as well as between the rs4977574 and rs7857345 polymorphisms and atherogenic stroke.
|
31824394 |
2019 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
CAD association was replicated for three GWAS-identified loci (1p13.3/SORT1 (rs599839), 9p21.3/CDKN2A/2B (rs4977574), and 11q22.3/ PDGFD (rs974819)) in Koreans.
|
23364394 |
2013 |
|
Malignant Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
rs4977574 on chromosome 9p21 was genotyped in 24 777 subjects from the Malmö Diet and Cancer study who were free from CVD prior to the baseline examination.
|
23480785 |
2013 |
|
Primary malignant neoplasm
|
|
0.010 |
GeneticVariation
|
BEFREE |
rs4977574 on chromosome 9p21 was genotyped in 24 777 subjects from the Malmö Diet and Cancer study who were free from CVD prior to the baseline examination.
|
23480785 |
2013 |
|
Cardiovascular Diseases
|
|
0.030 |
GeneticVariation
|
BEFREE |
rs4977574 on chromosome 9p21 was genotyped in 24 777 subjects from the Malmö Diet and Cancer study who were free from CVD prior to the baseline examination.
|
23480785 |
2013 |
|
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
GWASDB |
A common variant on chromosome 9p21 affects the risk of myocardial infarction.
|
17478679 |
2007 |
|
Coronary heart disease
|
|
0.840 |
GeneticVariation
|
GWASDB |
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.
|
21378988 |
2011 |
|
Coronary heart disease
|
|
0.840 |
GeneticVariation
|
GWASCAT |
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.
|
21378988 |
2011 |
|
Coronary heart disease
|
|
0.840 |
GeneticVariation
|
GWASDB |
A genome-wide association study of a coronary artery disease risk variant.
|
23364394 |
2013 |
|
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
BEFREE |
After age, sex, and BMI adjustment, we observed the SNPs rs12190287, rs12413409, rs1412444, rs1746048 and rs4977574, were significantly associated with MI in additive models and rs12190287, rs12413409, rs4977574 were significantly associated with phenotypes of MI at the same time.
|
24475106 |
2014 |
|
Acute Chest Syndrome
|
|
0.030 |
GeneticVariation
|
BEFREE |
An interaction for increased ACS risk was found between carriers of the chromosome 9p21 variant rs4977574 and low omega-3 index (OR 1.57, 95% CI 1.07-2.32, p = 0.02), but this was not significant after correction for multiple testing.
|
24998078 |
2014 |
|
Coronary heart disease
|
|
0.840 |
GeneticVariation
|
BEFREE |
ANRIL polymorphism rs4977574 is associated with increased risk of coronary artery disease in Asian populations: A meta-analysis of 12,005 subjects.
|
30278588 |
2018 |
|
Coronary Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
ANRIL polymorphism rs4977574 is associated with increased risk of coronary artery disease in Asian populations: A meta-analysis of 12,005 subjects.
|
30278588 |
2018 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
Association of rs4977574 with severity of CA</span>D was confirmed in the Canadian Study.
|
23343465 |
2013 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
Association of CDKN2BAS polymorphism rs4977574 with coronary heart disease: a case-control study and a meta-analysis.
|
25268619 |
2014 |
|
Coronary Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Association of CDKN2BAS polymorphism rs4977574 with coronary heart disease: a case-control study and a meta-analysis.
|
25268619 |
2014 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
Besides the CAD/MI SNP at 9p21 (rs4977574, P = 3.1 × 10(-10)), two additional loci at ADAMTS7 (rs3825807, P = 6.5 × 10(-6)) and at PHACTR1 (rs12526453, P = 1.0 × 10(-3)) show a nominally significant association with coronary artery calcification with MI/CAD risk alleles increasing the degree of arterial calcification.
|
23561647 |
2013 |
|
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
BEFREE |
Besides the CAD/MI SNP at 9p21 (rs4977574, P = 3.1 × 10(-10)), two additional loci at ADAMTS7 (rs3825807, P = 6.5 × 10(-6)) and at PHACTR1 (rs12526453, P = 1.0 × 10(-3)) show a nominally significant association with coronary artery calcification with MI/CAD risk alleles increasing the degree of arterial calcification.
|
23561647 |
2013 |
|
Calcification of coronary artery
|
|
0.700 |
GeneticVariation
|
GWASDB |
Candidate gene association study of coronary artery calcification in chronic kidney disease: findings from the CRIC study (Chronic Renal Insufficiency Cohort).
|
23727086 |
2013 |
|
Glioma
|
|
0.700 |
GeneticVariation
|
GWASDB |
Chromosome 7p11.2 (EGFR) variation influences glioma risk.
|
21531791 |
2011 |
|
Major Depressive Disorder
|
|
0.700 |
GeneticVariation
|
GWASDB |
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
|
23377640 |
2013 |
|
Glaucoma, Open-Angle
|
|
0.700 |
GeneticVariation
|
GWASDB |
Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma.
|
22570617 |
2012 |
|
Myocardial Infarction
|
|
0.880 |
GeneticVariation
|
BEFREE |
Comparisons of allele frequencies by the χ(2) test revealed that rs9369640 of the phosphatase and actin regulator 1 gene (PHACTR1, FDR=0.0007), rs4977574 of the CDKN2B antisense RNA 1 gene (CDKN2B-AS1, FDR=0.0038), rs264 of the lipoprotein lipase gene (LPL, FDR=0.0061), rs599839 of the proline/serine-rich coiled-coil 1 gene (PSRC1, FDR=0.0118), rs9319428 of the fms-related tyrosine kinase 1 gene (FLT1, FDR=0.0118) and rs12413409 of the cyclin and CBS domain divalent metal cation transport mediator 2 gene (CNNM2, FDR=0.0300) were significantly associated with MI.
|
25738804 |
2015 |
|
Coronary heart disease
|
|
0.840 |
GeneticVariation
|
BEFREE |
Five single-nucleotide polymorphisms, rs4977574 (CDKN2A/2B), rs12526453 (PHACTR1), rs646776 (CELSR2-PSRC1-SORT1), rs2259816 (HNF1A), and rs11206510 (PCSK9) showed directionally consistent associations with CHD in the 3 studies, with combined odds ratios (ORs) ranging from 1.17 to 1.25 (p = 0.03 to 0.0002).
|
22152955 |
2011 |
|
Coronary Artery Disease
|
|
0.890 |
GeneticVariation
|
BEFREE |
Four SNPs, rs4977574_A [0.56(0.50-0.63); p < 0.0001], rs10757274_A [0.87(0.77-0.97); p = 0.014], rs10738607_A [0.89(0.80-1.00); p = 0.043] and rs1333045_T [0.54(0.48-0.61); p < 0.0001] residing on the CDKN2B gene were significantly associated with CAD following multivariate adjustments for MI, HTN and DM, while four others were weakly associated with the disease.
|
29894795 |
2018 |