|
rs967771
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two additional SNPs, rs10051667 (S31) and rs967771 (S32), previously associated with alcohol dependence and bipolar disorder respectively, were also analyzed.
|
26561861 |
2015 |
|
rs110402
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study examined the influence of an intronic CRHR1 gene variant, rs110402, on brain responses to negative emotional words, negative emotional traits, and alcohol use in adolescents and young adults at high risk for alcoholism.
|
24623788 |
2014 |
|
rs149775276
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, one variant (rs149775276; H329Y) shows association with both cocaine dependence symptoms (P = 7.4 × 10(-5), β = 2.04) and alcohol dependence symptoms (P = 2.6 × 10(-4), β = 2.04).
|
24057674 |
2014 |
|
rs149775276
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, one variant (rs149775276; H329Y) shows association with both cocaine dependence symptoms (P = 7.4 × 10(-5), β = 2.04) and alcohol dependence symptoms (P = 2.6 × 10(-4), β = 2.04).
|
24057674 |
2014 |
|
rs17037102
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Furthermore, rs17037102 was in linkage disequilibrium with the nonexonic DKK2 SNPs which showed associations with AD in the previous study with Irish population, which suggests that rs17037102 may be the causal SNP.
|
24117450 |
2014 |
|
rs1800498
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to evaluate 3 single nucleotide polymorphisms: D2 (rs1076560), Tag1D (rs1800498), Tag1B (rs1079597) located in dopamine receptor 2 DRD2 gene and its role in alcohol dependence.
|
25380208 |
2014 |
|
rs35349697
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One SNP in exon 3, rs35349697, demonstrated a significant correlation with opioid addiction as well as with alcohol addiction.
|
24704376 |
2014 |
|
rs3771829
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To further elucidate the role of TACR1 in affective disorders, rs3771829 was genotyped in a second BPAD sample of 593 subjects (UCL2), in 997 subjects with ADS, and a subsample of 143 individuals diagnosed with BPAD and comorbid alcohol dependence (BPALC). rs3771829 was associated with BPAD (UCL1 and UCL2 combined: P = 2.0 × 10(-3)), ADS (P = 2.0 × 10(-3)) and BPALC (P = 6.0 × 10(-4)) compared with controls screened for the absence of mental illness and alcohol dependence.
|
24817687 |
2014 |
|
rs4147541
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three mQTLs (rs2173201, rs4147542, and rs4147541 in ADH1B-AHD1C gene cluster region) found in AAs were previously identified by our genome-wide association studies as being significantly associated with AD in AAs.
|
24889829 |
2014 |
|
rs4147542
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Three mQTLs (rs2173201, rs4147542, and rs4147541 in ADH1B-AHD1C gene cluster region) found in AAs were previously identified by our genome-wide association studies as being significantly associated with AD in AAs.
|
24889829 |
2014 |
|
rs779838446
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, one variant (rs149775276; H329Y) shows association with both cocaine dependence symptoms (P = 7.4 × 10(-5), β = 2.04) and alcohol dependence symptoms (P = 2.6 × 10(-4), β = 2.04).
|
24057674 |
2014 |
|
rs991316
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additional linkage analysis suggested that nearby variants in linkage disequilibrium with rs991316 were not responsible for the observed association with the alcohol dependence phenotypes in this study.
|
25527893 |
2014 |
|
rs10160548
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subsequent analysis of these two interaction models revealed an OR of 2.71 and 2.80, respectively, for AD (P < 0.001) in carriers of genotype combinations 5'-HTTLPR:LL/LS(SLC6A4)-rs1042173:TT/TG(SLC6A4)-rs1176744:AC(HTR3B)-rs3782025:AG(HTR3B) and 5'-HTTLPR:LL/LS(SLC6A4)-rs10160548:GT/TT(HTR3A)-rs1176744:AC(HTR3B)-rs3782025:AG(HTR3B).
|
23757001 |
2013 |
|
rs1042173
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subsequent analysis of these two interaction models revealed an OR of 2.71 and 2.80, respectively, for AD (P < 0.001) in carriers of genotype combinations 5'-HTTLPR:LL/LS(SLC6A4)-rs1042173:TT/TG(SLC6A4)-rs1176744:AC(HTR3B)-rs3782025:AG(HTR3B) and 5'-HTTLPR:LL/LS(SLC6A4)-rs10160548:GT/TT(HTR3A)-rs1176744:AC(HTR3B)-rs3782025:AG(HTR3B).
|
23757001 |
2013 |
|
rs1051740
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found significant association between EPHX1 gene Tyr113His polymorphism and alcoholism in the Kota population (T vs. C: OR = .615, 95% CI = .399-.949, p = .027; TT vs. CC + CT: OR = .536, 95% CI = .297-.969, p = .038).
|
22257321 |
2013 |
|
rs12597786
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two SNPs (rs12597786 and rs7204609) associated with AD in the SAGE sample (p = 0.017 and 0.034, respectively) were replicated in the COGA sample (p = 0.017 and 0.014, respectively).
|
23771786 |
2013 |
|
rs1611115
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs1611115 (near 5') C-allele and related haplotypes were significantly associated with alcohol dependence in females.
|
23906995 |
2013 |
|
rs16969968
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The analysis revealed a candidate SNP from CHRNA5, rs16969968, associated with both ND and AD, and replicated the findings in an independent dataset with a P-value of 1.06 × 10(-03) .
|
23334941 |
2013 |
|
rs173365
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In block 2, rs17689966 (P = 0.018) showed significant and rs173365 (P = 0.026) showed nominally significant, gene × environment (G × E) effects on alcoholism status.
|
23473364 |
2013 |
|
rs17689966
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In block 2, rs17689966 (P = 0.018) showed significant and rs173365 (P = 0.026) showed nominally significant, gene × environment (G × E) effects on alcoholism status.
|
23473364 |
2013 |
|
rs17817449
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, we found association of rs17817449 (which has a strong linkage disequilibrium with rs9939609) with AD in the SAGE sample (p = 0.00339).
|
23771786 |
2013 |
|
rs2072450
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These results indicate that rs2072450 might confer risk for alcohol dependence through deficient fear acquisition indexed by a diminished amygdala response during aversive learning, and provide a neural basis for a weak behavioral inhibition previously documented in individuals at high risk for alcohol dependence.
|
23693003 |
2013 |
|
rs2239803
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The best novel signal was SNP rs2239803 associated with AD in both samples (p = 0.000817 for the COGA sample and p = 0.0026 for the SAGE sample, respectively) while one flanking SNP rs4935356 also showed strong association in both samples (p = 0.00219 and 0.0026 for the COGA and SAGE samples, respectively).
|
22890421 |
2013 |
|
rs2276305
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the alleles of the low-frequency SNPs rs33940208:T in HTR3A and rs2276305:A in HTR3B were inversely and nominally significantly associated with AD with odds ratio (OR) and 95 % confidence interval of 0.212 and 0.073, 0.616 (P = 0.004) and 0.261 and 0.088, 0.777 (P = 0.016), respectively.
|
23757001 |
2013 |
|
rs33940208
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that the alleles of the low-frequency SNPs rs33940208:T in HTR3A and rs2276305:A in HTR3B were inversely and nominally significantly associated with AD with odds ratio (OR) and 95 % confidence interval of 0.212 and 0.073, 0.616 (P = 0.004) and 0.261 and 0.088, 0.777 (P = 0.016), respectively.
|
23757001 |
2013 |