|
rs3782025
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Subsequent analysis of these two interaction models revealed an OR of 2.71 and 2.80, respectively, for AD (P < 0.001) in carriers of genotype combinations 5'-HTTLPR:LL/LS(SLC6A4)-rs1042173:TT/TG(SLC6A4)-rs1176744:AC(HTR3B)-rs3782025:AG(HTR3B) and 5'-HTTLPR:LL/LS(SLC6A4)-rs10160548:GT/TT(HTR3A)-rs1176744:AC(HTR3B)-rs3782025:AG(HTR3B).
|
23757001 |
2013 |
|
rs4935356
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The best novel signal was SNP rs2239803 associated with AD in both samples (p = 0.000817 for the COGA sample and p = 0.0026 for the SAGE sample, respectively) while one flanking SNP rs4935356 also showed strong association in both samples (p = 0.00219 and 0.0026 for the COGA and SAGE samples, respectively).
|
22890421 |
2013 |
|
rs5916144
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that, after experiment-wide correction, two SNPs on the X chromosome were associated significantly with alcohol dependence in European-American men (P = 1.0 × 10 for rs5916144 and P = 5.5 × 10 for rs5961794 at 3' UTR of NLGN4X), but not in the women.
|
23907288 |
2013 |
|
rs5961794
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that, after experiment-wide correction, two SNPs on the X chromosome were associated significantly with alcohol dependence in European-American men (P = 1.0 × 10 for rs5916144 and P = 5.5 × 10 for rs5961794 at 3' UTR of NLGN4X), but not in the women.
|
23907288 |
2013 |
|
rs7204609
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two SNPs (rs12597786 and rs7204609) associated with AD in the SAGE sample (p = 0.017 and 0.034, respectively) were replicated in the COGA sample (p = 0.017 and 0.014, respectively).
|
23771786 |
2013 |
|
rs8062891
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Through meta-analysis of two samples using PLINK, the top three SNPs associated with AD were rs8062891, rs12597786, and rs7204609 (p = 0.00064, 0.00076 and 0.0011, respectively).
|
23771786 |
2013 |
|
rs900418273
|
|
|
0.010 |
GeneticVariation |
BEFREE |
COMT Val158Met modulates the effect of childhood adverse experiences on the risk of alcohol dependence.
|
22509987 |
2013 |
|
rs10009145
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype ATAAAT, which contained the minor allele of rs10009145 and the major allele of rs7689753, increased the risk of alcohol dependence, whereas haplotype GGGGAT, bearing the major allele of rs10009145 and the minor allele of rs7689753, protected against it.
|
22044940 |
2012 |
|
rs1034866440
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we explored whether functionally relevant genetic polymorphisms in SRD5A2 (V89L, A49T, [TA](n)) are linked to alcohol addiction and craving.
|
22707254 |
2012 |
|
rs11568817
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The results suggest an association between a functional variant of the gene (rs11568817) and alcohol dependence (p=0.001).
|
22005095 |
2012 |
|
rs130058
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study is to investigate the role of the most relevant variants (rs11568817, rs130058, rs6296 and rs13212041) of the HTR1B gene in the susceptibility to alcohol dependence.
|
22005095 |
2012 |
|
rs13212041
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study is to investigate the role of the most relevant variants (rs11568817, rs130058, rs6296 and rs13212041) of the HTR1B gene in the susceptibility to alcohol dependence.
|
22005095 |
2012 |
|
rs137852569
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we explored whether functionally relevant genetic polymorphisms in SRD5A2 (V89L, A49T, [TA](n)) are linked to alcohol addiction and craving.
|
22707254 |
2012 |
|
rs1800532
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our aim was to assess the association of TPH1 A218C polymorphism (rs1800532) with mood disorders, including major depressive disorder and bipolar disorder, and alcohol dependence by using meta-analysis.
|
21601290 |
2012 |
|
rs1800564
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we explored whether functionally relevant genetic polymorphisms in SRD5A2 (V89L, A49T, [TA](n)) are linked to alcohol addiction and craving.
|
22707254 |
2012 |
|
rs2273816
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One SNP rs2273816 was found to be significantly associated with schizophrenia, opiate dependence and alcohol dependence at the genotype and allele level.
|
22960338 |
2012 |
|
rs279826
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a sample of 173 families (449 subjects), 129 of whom had at least one member diagnosed with alcohol dependence or abuse, carriers for the G allele in two single-nucleotide polymorphisms (SNPs) and haplotypes were more likely to have alcohol dependence symptoms (rs279858, P=0.01; rs279826, P=0.05; haplotype, P=0.02) and higher NEO Personality Inventory-Revised (NEO-PI-R) Impulsiveness scores (rs279858, P=0.016; rs279826, P=0.012; haplotype, P=0.032) with a stronger effect in women (rs279858, P=0.011; rs279826, P=0.002; haplotype, P=0.006), all P-values are corrected for family history and age.
|
21483437 |
2012 |
|
rs36020
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two single nucleotide polymorphisms (SNP) (rs36020 and rs36029) in SLC6A2 were significantly associated with alcoholism [false discovery rate corrected P-value (FDR) P = 0.007].
|
21070505 |
2012 |
|
rs36029
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two single nucleotide polymorphisms (SNP) (rs36020 and rs36029) in SLC6A2 were significantly associated with alcoholism [false discovery rate corrected P-value (FDR) P = 0.007].
|
21070505 |
2012 |
|
rs371308207
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results show statistically significant associations between SNP in exon 8 A/G in the DRD2 gene and alcohol withdrawal syndrome with seizures, and between SNP in promoter -141 C I/D in the DRD2 gene and early onset of alcohol dependence (AD).
|
23238469 |
2012 |
|
rs521674
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two SNPs in ADRA2A (rs521674 and rs602618) were associated with a positive family history of alcoholism (FDR P ≤ 0.05).
|
21070505 |
2012 |
|
rs523349
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we explored whether functionally relevant genetic polymorphisms in SRD5A2 (V89L, A49T, [TA](n)) are linked to alcohol addiction and craving.
|
22707254 |
2012 |
|
rs602618
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two SNPs in ADRA2A (rs521674 and rs602618) were associated with a positive family history of alcoholism (FDR P ≤ 0.05).
|
21070505 |
2012 |
|
rs727532
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Especially, SNP rs727532 within ABLIM1 gene at 10q25 showed the most significant association (p = 6.4 × 10(-5)) in the multivariate test and strong associations with NS, HA, RD, and AD (p = 4.48 × 10(-4), 1.2 × 10(-5), 5.6 × 10(-5), 3.12 × 10(-4), respectively) in the COGA sample.
|
21547531 |
2012 |
|
rs738409
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Patatin-like phospholipase domain-containing 3 (PNPLA3) I148M (rs738409) genetic variant has been associated with hepatocellular carcinoma (HCC) in individuals with chronic alcohol abuse or hepatic viral infection.
|
22704398 |
2012 |