|
rs1333049
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
Of thousands of chromosomal loci studied, the same locus had the strongest association with coronary artery disease in both the WTCCC and the German studies: chromosome 9p21.3 (SNP, rs1333049) (P=1.80x10(-14) and P=3.40x10(-6), respectively).
|
17634449 |
2007 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Two-marker association tests yield new disease associations for coronary artery disease and hypertension.
|
21626137 |
2011 |
|
rs1333049
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
|
17554300 |
2007 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Independent association of the variant rs1333049 at the 9p21 locus and coronary heart disease.
|
21874923 |
2011 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The results showed that 3 SNPs in whites (rs599839, rs1333049, and rs501120; HRRs were 1.10 (P = 0.044), 1.14 (P < 0.001), and 1.14 (P = 0.030), respectively) and 1 SNP in African Americans (rs7250581; HRR = 1.60, P = 0.05) were significantly associated with incident CHD.
|
19955471 |
2010 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Using the combined TDT/S-TDT test, the 3 single nucleotide polymorphisms (SNP), rs10757274, rs2383206 and rs1333049, were strongly associated with early-onset CHD (p = 2.7 x 10(-6), 2.7 x 10(-6), 3.8 x 10(-7), respectively).
|
18957718 |
2008 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
SNP rs1333049 on chromosome 9p21.3 was associated with both CHD and stroke (HR=1.20, 95% CI 1.08-1.34 for incident CHD events and 1.15, 0.99-1.34 for incident stroke).
|
18979498 |
2009 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
However, the effect of rs1333049 on clinical outcomes in patients with established coronary disease has yet to be determined.
|
20400779 |
2010 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our study aims to explore the association of rs7025486 single-nucleotide polymorphisms (SNP) in DAB2IP and rs1333049 on chromosome 9p21.3 with the coronary artery disease in Chinese population.
|
28962556 |
2017 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Despite excellent power, the 9p21 locus SNP (rs1333049) was only modestly associated with MI (HR = 1.09, p-value = 0.02) and marginally with CHD (HR = 1.06, p-value = 0.08).
|
26950853 |
2016 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
To address the relationship of rs1333049, the 9p21 variant showing the strongest association with coronary heart disease (CHD), with carotid plaques and plaque-free common carotid artery intima-media thickness (CCA-IMT) in older adults from 2 French population-based cohorts.
|
22436605 |
2012 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Of thousands of chromosomal loci studied, the same locus had the strongest association with coronary artery disease in both the WTCCC and the German studies: chromosome 9p21.3 (SNP, rs1333049) (P=1.80x10(-14) and P=3.40x10(-6), respectively).
|
17634449 |
2007 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Large-scale gene-centric analysis identifies novel variants for coronary artery disease.
|
21966275 |
2011 |
|
rs1333049
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Of thousands of chromosomal loci studied, the same locus had the strongest association with coronary artery disease in both the WTCCC and the German studies: chromosome 9p21.3 (SNP, rs1333049) (P=1.80x10(-14) and P=3.40x10(-6), respectively).
|
17634449 |
2007 |
|
rs1333049
|
|
C |
0.900 |
GeneticVariation |
GWASDB |
A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease.
|
21606135 |
2011 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The Ch9p21 SNPs rs1333049 (OR 1.17; 95% confidence limits 1.11-1.24) and rs10757274 (OR 1.17; 1.09-1.26), MIA3 rs17465637 (OR 1.10; 1.04-1.15), Ch2q36 rs2943634 (OR 1.08; 1.03-1.14), APC rs383830 (OR 1.10; 1.02, 1.18), MTHFD1L rs6922269 (OR 1.10; 1.03, 1.16), CXCL12 rs501120 (OR 1.12; 1.04, 1.20), and SMAD3 rs17228212 (OR 1.11; 1.05, 1.17) were all associated with CHD risk, but not with the CHD biomarkers and risk factors measured.
|
21804106 |
2012 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Gender-based subgroup tests showed that four polymorphisms (rs75227345, rs2383205, rs10738606 and rs1333049) were associated with CHD in males (p < .05).
|
31496134 |
2019 |
|
rs1333049
|
|
C |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
|
17554300 |
2007 |
|
rs1333049
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.
|
22751097 |
2012 |
|
rs671
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We genotyped rs671 of ALDH2 in 96 coronary heart disease (CHD) patients with four methods including high resolution melting analysis (HRM), TaqMan allelic discrimination assay (TaqMan), allele-specific PCR (AS-PCR) and pyrosequencing.
|
25803854 |
2015 |
|
rs671
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism is an established genetic risk of hypertension, diabetes, and coronary heart diseases in Asian population.
|
30846829 |
2020 |
|
rs671
|
|
A |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study of coronary artery disease in the Japanese.
|
21971053 |
2012 |
|
rs671
|
|
A |
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association study of coronary artery disease in the Japanese.
|
21971053 |
2012 |
|
rs671
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Previous studies demonstrated that aldehyde dehydrogenase 2 (ALDH2) rs671 polymorphism, which eliminates ALDH2 activity down to 1%-6%, is a susceptibility gene for coronary disease.
|
27191745 |
2016 |
|
rs671
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The association between the aldehyde dehydrogenase 2 (ALDH2, rs671) genotypes and the estimated glomerular filtration rate (eGFR) was investigated in Japanese hypertensive patients with/without coronary artery disease or with ischemic heart failure (HF), and age/sex-matched normotensive healthy controls.
|
24067347 |
2014 |