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rs1800977
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphism rs1800977 was associated with susceptibility to CHD (AA vs GG, P = 0.013; A vs G, P = 0.029; recessive model, P = 0.020).
|
31006134 |
2019 |
|
rs181317402
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Luciferase activity assay showed that rs181317402 allele G significantly increased the basal and Nkx2.5-mediated activity of GDF1 promoter, while the two genetic mutations had the opposite effect. rs181317402 TG genotype was associated with significantly increased mRNA level of GDF1 compared with TT genotype in 18 CHD individuals.
|
31171573 |
2019 |
|
rs182052
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Regression analysis revealed an increase in prevalence of unstable angina (OR (odds ratio) = 2.55; 95%CI 1.4-4.82; p = 0.018) and coronary artery disease (OR = 1.55; 95%CI 1.15-2.09; p = 0.021) per copy of the rs182052 A allele.
|
31561637 |
2019 |
|
rs184003
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs184003 SNP seems related to coronary artery disease, breast cancer, and diabetes.
|
30863465 |
2019 |
|
rs1883832
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Homozygosity for the C allele of the -1T>C SNP of the CD40 gene (rs1883832) results in an enhanced CD40 surface abundance and pro-inflammatory phenotype of vascular endothelial cells, increasing the susceptibility to atherosclerosis and CHD in humans.This appears to be compensated by an enhanced shedding of sCD40 from the endothelial cell membrane to neutralize excess CD40 ligand. sCD40 might be a potential new biomarker for the pro-inflammatory processes occurring in atherosclerosis.
|
31373353 |
2019 |
|
rs231150
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs2954029-rs231150 interactions had an increased risk of both CHD and IS.
|
30787327 |
2019 |
|
rs2383205
|
|
|
0.010 |
GeneticVariation |
BEFREE |
And age-based subgroup tests indicated that rs2383205 and rs10738606 were associated with CHD among individuals, respectively (p < .05).
|
31496134 |
2019 |
|
rs2870463
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two novel loci were associated with birthweight and adult coronary artery disease (rs2870463 in CTRB1) and with birthweight and adult waist circumference (rs12704673 in CALCR).
|
30858448 |
2019 |
|
rs2954029
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The rs2954029-rs231150 interactions had an increased risk of both CHD and IS.
|
30787327 |
2019 |
|
rs3798343
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association between peroxisome proliferator-activated receptor Δ rs3777744, rs3798343, and rs6922548 and coronary artery disease.
|
30429241 |
2019 |
|
rs3834458
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association of Nonalcoholic Fatty Liver Disease and Coronary Artery Disease with FADS2 rs3834458 Gene Polymorphism in the Chinese Han Population.
|
31781193 |
2019 |
|
rs439401
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We try to explore whether long-term consumption of two healthy dietary patterns (low-fat [LF] diet or Mediterranean diet [MedDiet]) interacts with the apolipoprotein E (APOE) single-nucleotide polymorphisms (SNPs: rs439401, rs440446 and rs7412) modulating postprandial hypertriglyceridemia (ppHTG) in coronary heart disease (CHD) patients.
|
31166609 |
2019 |
|
rs440446
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We try to explore whether long-term consumption of two healthy dietary patterns (low-fat [LF] diet or Mediterranean diet [MedDiet]) interacts with the apolipoprotein E (APOE) single-nucleotide polymorphisms (SNPs: rs439401, rs440446 and rs7412) modulating postprandial hypertriglyceridemia (ppHTG) in coronary heart disease (CHD) patients.
|
31166609 |
2019 |
|
rs4455026
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The minor C allele of rs4455026 in TBX2 promoter region was related with lower CHD susceptibility in the Han Chinese population via repressing its transcriptional activity.
|
30525309 |
2019 |
|
rs4717806
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Finally, a statistical association of rs4717806(AA) genotype with higher TyG index in IHD patients (P = .03) was highlighted by multiple regression analysis considering log-transformed biochemical parameters as dependent variable and presence of coronary artery disease, age, gender, waist circumference, presence of diabetes as predictors.
|
31192914 |
2019 |
|
rs4720169
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Two variants were found to confer a risk of CHDs: variant rs4720169 of <i>TBX20</i> in which the OR for the heterozygous state was 1.88 (95% confidence interval [CI]: 1.12-3.14, <i>p</i> = 0.010), whereas the OR for the homozygous state was 3.82 (95% CI: 1.18-12.3, <i>p</i> = 0.010); and variant rs12921862 of <i>AXIN1</i> in which the OR for the heterozygous state was 4.15 (95% CI: 2.42-7.10; <i>p</i> ≤ 0.001), whereas the OR for the homozygous state was 9.2 (95% CI: 1.31-64.7, <i>p</i> = 0.008) for allele A.
|
31524541 |
2019 |
|
rs4809324
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the allele model, using the chi-square test, we found that the patients with the "G" allele of rs6010620 and the "C" allele of rs4809324 in the RTEL1 gene showed a decreased risk of CHD once the results were adjusted for age and gender.
|
30623606 |
2019 |
|
rs4919687
|
|
|
0.010 |
GeneticVariation |
BEFREE |
It showed that A allele of CYP17A1 rs4919687 carried with a 1.59-fold increased risk of CHD (OR = 1.59; 95% CI = 1.26-1.99; P < 0.001).
|
31356544 |
2019 |
|
rs59382073
|
|
|
0.010 |
GeneticVariation |
BEFREE |
T allele of rs59382073 in TBX2 3'UTR contributed to greater CHD risk in the Han Chinese population.
|
30262811 |
2019 |
|
rs6010620
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the genetic model, logistic regression analyses revealed that the rs6010620 polymorphism conferred a decreased risk of CHD in the codominant model (OR = 0.52, 95% CI: 0.31-0.88, p = 0.007 for the "G/G" genotype) and the recessive model (OR = 0.49, 95% CI: 0.30-0.80, p = 0.004 for the "G/G" genotype).
|
30623606 |
2019 |
|
rs6505162
|
|
|
0.010 |
GeneticVariation |
BEFREE |
However, no studies have reported the association between miRNA-423 rs6505162 C>A polymorphism and susceptibility of coronary artery disease.
|
30289085 |
2019 |
|
rs6859
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The high confidence (determined by miCLIP experiment) m<sup>6</sup>A-SNP rs6859 at the 3'-untranslated region of PVRL2 was associated with high-density lipoprotein cholesterol (P = 1.21 × 10<sup>-15</sup>), low-density lipoprotein cholesterol (P = 1.77 × 10<sup>-106</sup>), total cholesterol (P = 4.82 × 10<sup>-82</sup>), and triglycerides (P = 8.10 × 10<sup>-5</sup>) levels, coronary artery disease (P = 0.01), as well as PVRL2 mRNA expression in artery tibial (P = 2.38 × 10<sup>-6</sup>) and whole blood (P = 5.59 × 10<sup>-19</sup>).
|
30262821 |
2019 |
|
rs6882076
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<b>Conclusions</b>: The results of the present study suggest that the <i>TIMD4</i> rs6882076 SNP is associated with decreased risk of CHD and IS in our study population.
|
31337960 |
2019 |
|
rs6922548
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association between peroxisome proliferator-activated receptor Δ rs3777744, rs3798343, and rs6922548 and coronary artery disease.
|
30429241 |
2019 |
|
rs748737164
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Here, we not only report, for the first time, a c.1309G>A-related CHD, but also report a novel de novo balanced translocation, 46,XY,t(5;7)(qter13;qter11), in the same patient which may have influenced the disease severity.
|
31115957 |
2019 |