|
rs10859871
|
|
|
0.850 |
GeneticVariation |
BEFREE |
In addition, we establish an association of rs13394619 in GREB1 at 2p25.1 with endometriosis and identify a newly associated locus at 12q22 near VEZT (rs10859871).
|
23104006 |
2012 |
|
rs10859871
|
|
|
0.850 |
GeneticVariation |
BEFREE |
In the present study, an association of rs7521902 (WNT4) and rs10859871 (VEZT) was confirmed in women with endometriosis at the genotypic but not the allelic level.
|
28901453 |
2017 |
|
rs10859871
|
|
|
0.850 |
GeneticVariation |
BEFREE |
Endometriosis risk SNPs (including rs10859871) located within this locus demonstrated evidence for ITALIC! cis-eQTLs on ITALIC!VEZT expression.
|
27005890 |
2016 |
|
rs10859871
|
|
|
0.850 |
GeneticVariation |
BEFREE |
Genome-wide and candidate-gene association studies for endometriosis have identified 10 independent risk loci, and of these, nine (rs7521902, rs13394619, rs4141819, rs6542095, rs1519761, rs7739264, rs12700667, rs1537377, and rs10859871) are polymorphic in European populations.
|
26337243 |
2015 |
|
rs10859871
|
|
|
0.850 |
GeneticVariation |
BEFREE |
Meta-analysis with previous data confirmed the rs10859871 </span>SNP as that with the strongest evidence for association with endometriosis (OR = 1.19, 95% CI: 1.15-1.24, P = 7.9 × 10(-20)).
|
25678572 |
2015 |
|
rs7521902
|
|
|
0.850 |
GeneticVariation |
BEFREE |
Genome-wide and candidate-gene association studies for endometriosis have identified 10 independent risk loci, and of these, nine (rs7521902, rs13394619, rs4141819, rs6542095, rs1519761, rs7739264, rs12700667, rs1537377, and rs10859871) are polymorphic in European populations.
|
26337243 |
2015 |
|
rs7521902
|
|
|
0.850 |
GeneticVariation |
BEFREE |
The meta-analysis showed that rs7521902 was associated with endometriosis at a genome-wide significance (p(meta)=2.23×10(-9)) while for rs1250248, a genome-wide significant p(meta) value of 3.89×10(-9) was detected only in association with severe forms.
|
23142796 |
2013 |
|
rs7521902
|
|
|
0.850 |
GeneticVariation |
BEFREE |
In the present study, an association of rs7521902 (WNT4) and rs10859871 (VEZT) was confirmed in women with endometriosis at the genotypic but not the allelic level.
|
28901453 |
2017 |
|
rs7521902
|
|
|
0.850 |
GeneticVariation |
BEFREE |
No significant association was found between endometriosis and rs7521902 (A/C), rs16826658 (G/T), or rs7515106 (C/T).
|
25682310 |
2015 |
|
rs7521902
|
|
|
0.850 |
GeneticVariation |
BEFREE |
TaqMan allelic discrimination technique was used to investigate the relationship between endometriosis and four single-nucleotide polymorphisms (rs16826658, rs3820282, rs2235529, and rs7521902) in WNT4 gene.
|
26139156 |
2015 |
|
rs13394619
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Fine mapping results identified a number of SNPs showing stronger association (0.004 < P < 0.032) with endometriosis risk than the original GWAS SNP (rs13394619) (P = 0.034).
|
25788566 |
2015 |
|
rs13394619
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Notably, three coding variants in GREB1 (near rs13394619) and CDKN2B-AS1 (near rs1537377) also showed nominally significant associations with endometriosis.
|
26337243 |
2015 |
|
rs13394619
|
|
|
0.840 |
GeneticVariation |
BEFREE |
In addition, we establish an association of rs13394619 in GREB1 at 2p25.1 with endometriosis and identify a newly associated locus at 12q22 near VEZT (rs10859871).
|
23104006 |
2012 |
|
rs13394619
|
|
|
0.840 |
GeneticVariation |
BEFREE |
Is it possible to replicate the genetic association of single nucleotide polymorphisms (SNPs) rs13394619, rs4141819, rs7739264, rs17694933 and rs10859871 in five genetic loci previously identified as associated with endometriosis in an Italian Caucasian population?
|
25678572 |
2015 |
|
rs10965235
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Our results suggest that the rs10965235 SNP in the CDKN2B-AS gene and the rs16826658 SNP near the WNT4 gene were significantly associated with endometriosis in this Korean population.
|
25154675 |
2014 |
|
rs10965235
|
|
|
0.820 |
GeneticVariation |
BEFREE |
Through a genome-wide association study and a replication study using a total of 1,907 Japanese individuals with endometriosis (cases) and 5,292 controls, we identified a significant association of endometriosis with rs10965235 (P = 5.57 x 10(-12), odds ratio = 1.44), which is located in CDKN2BAS on chromosome 9p21, encoding the cyclin-dependent kinase inhibitor 2B antisense RNA.
|
20601957 |
2010 |
|
rs12700667
|
|
|
0.820 |
GeneticVariation |
BEFREE |
The strongest association signal was on 7p15.2 (rs12700667) for 'all' endometriosis (P = 2.6 × 10⁻⁷, odds ratio (OR) = 1.22, 95% CI 1.13-1.32) and for moderate to severe disease (P = 1.5 × 10⁻⁹, OR = 1.38, 95% CI 1.24-1.53).
|
21151130 |
2011 |
|
rs12700667
|
|
|
0.820 |
GeneticVariation |
BEFREE |
The study suggests that the endometriosis-associated genetic polymorphisms (rs12700667) from GWAS be associated with the risk of developing ovarian endometriosis in North Chinese women.
|
27233752 |
2017 |
|
rs12700667
|
|
|
0.820 |
GeneticVariation |
GWASCAT |
Genome-wide genetic analyses highlight mitogen-activated protein kinase (MAPK) signaling in the pathogenesis of endometriosis.
|
28333195 |
2017 |
|
rs2235529
|
|
|
0.820 |
GeneticVariation |
BEFREE |
The results demonstrated that WNT4 rs2235529 is associated with endometriosis in Chinese Han women, which may result in aberrant expression of WNT4, leading to the pathogenesis of endometriosis.
|
25682310 |
2015 |
|
rs2235529
|
|
|
0.820 |
GeneticVariation |
BEFREE |
This might constitute the first step towards identifying polymorphism combinations that predispose to endometriosis (IFNG (CA) repeat, GSTM1 null genotype, GSTP1 rs1695, WNT4 rs16826658 and WNT4 rs2235529) in a large cohort of patients with well-defined inclusion criteria.
|
31821471 |
2020 |
|
rs4141819
|
|
|
0.820 |
GeneticVariation |
BEFREE |
SNP rs10859871 near the vezatin (VEZT) gene was found to be significantly associated with endometriosis in general while SNPs rs17694933 and rs4141819 were associated with Stage III/IV and ovarian disease, respectively.
|
25678572 |
2015 |
|
rs4141819
|
|
|
0.820 |
GeneticVariation |
BEFREE |
In addition to the six loci, two showed borderline genome-wide significant associations with Stage III/IV endometriosis, including rs1250248 in FN1 (P = 8 × 10(-8)) and rs4141819 on 2p14 (P = 9.2 × 10(-8)).
|
24676469 |
2014 |
|
rs1537377
|
|
|
0.810 |
GeneticVariation |
BEFREE |
Notably, three coding variants in GREB1 (near rs13394619) and CDKN2B-AS1 (near rs1537377) also showed nominally significant associations with endometriosis.
|
26337243 |
2015 |
|
rs7739264
|
|
|
0.810 |
GeneticVariation |
BEFREE |
Is it possible to replicate the genetic association of single nucleotide polymorphisms (SNPs) rs13394619, rs4141819, rs7739264, rs17694933 and rs10859871 in five genetic loci previously identified as associated with endometriosis in an Italian Caucasian population?
|
25678572 |
2015 |