|
rs710886
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Finally, a significant genetic effect was observed in both the dominant (AG+GG vs AA) and recessive models (GG vs AG+AA), indicating the presence of an association between the genotype of SNP rs710886 and the risk of endometriosis.
|
31595574 |
2020 |
|
rs11615
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The multivariate logistic regression analysis showed that subjects carrying the ERCC1 rs11615 TT (OR = 2.04, 95% CI = 1.36-3.41), ERCC2 rs1799793 AA (OR = 1.86, 95% CI = 1.14-3.11), and ERCC6 rs2228528 AA genotypes (OR = 1.79, 95% CI = 1.13-2.83) exhibited significantly increased risks of developing endometriosis compared with their counterparts carrying the wild-type genotypes.
|
31373346 |
2019 |
|
rs11977660
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Genotypes with a T nucleotide at rs11977660 may significantly increase risk of endometriosis in Chinese.
|
31027056 |
2019 |
|
rs1536309
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CT/CC genotype of miR-146b rs1536309 was associated with the risk of pain symptom of endometriosis.
|
31122533 |
2019 |
|
rs1799793
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The multivariate logistic regression analysis showed that subjects carrying the ERCC1 rs11615 TT (OR = 2.04, 95% CI = 1.36-3.41), ERCC2 rs1799793 AA (OR = 1.86, 95% CI = 1.14-3.11), and ERCC6 rs2228528 AA genotypes (OR = 1.79, 95% CI = 1.13-2.83) exhibited significantly increased risks of developing endometriosis compared with their counterparts carrying the wild-type genotypes.
|
31373346 |
2019 |
|
rs2020917
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We failed to find any significant association between rs2020917 and endometriosis risk in the crude results.
|
30608422 |
2019 |
|
rs2072454
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No significant association was found between genotype at rs2072454 and endometriosis.
|
31027056 |
2019 |
|
rs2228528
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The multivariate logistic regression analysis showed that subjects carrying the ERCC1 rs11615 TT (OR = 2.04, 95% CI = 1.36-3.41), ERCC2 rs1799793 AA (OR = 1.86, 95% CI = 1.14-3.11), and ERCC6 rs2228528 AA genotypes (OR = 1.79, 95% CI = 1.13-2.83) exhibited significantly increased risks of developing endometriosis compared with their counterparts carrying the wild-type genotypes.
|
31373346 |
2019 |
|
rs2237895
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Gene variant (AC/CC) of KCNQ1 rs2237895 showed a slight difference in the endometriosis group compared to the fertile group (p = .049), with the C allele showing a significant association with infertility overall (OR = 1.42 [1.100-1.833]; p < .0069).
|
31579970 |
2019 |
|
rs354476
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Immunohistofluorescence analysis for assessing whether GP210 is expressed in endometrial tissues from patients and controls; genotyping and case-control study for assessing the association between rs354476 within NUP210 and risk of endometriosis; in vitro luciferase assay for assessing the functional activity of rs354476.
|
31256999 |
2019 |
|
rs591291
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The MALAT1 rs591291 C > T polymorphism was associated with a significant increase in endometriosis risk.
|
31803924 |
2019 |
|
rs7574865
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A single-polymorphism analysis revealed that the TT genotype of the rs7574865/T > G polymorphism was significantly more frequent in women with minimal or mild endometriosis than in the controls (10% vs. 5%, p = 0.047).
|
30887509 |
2019 |
|
rs12030576
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A known dysmenorrhea signal near NGF replicated in our data (rs12030576; P = 1.1 × 10<sup>-19</sup>) and was associated with RP4-663N10.1 expression, a putative lncRNA enhancer of NGF, while a novel dysmenorrhea signal in the IL1 locus (rs80111889; P = 1.9 × 10<sup>-16</sup>) contained SNPs previously associated with endometriosis, and GWAS SNPs were most significantly associated with IL1A expression.
|
29855537 |
2018 |
|
rs174538
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The FEN1 rs174538 A allele is a novel protective biomarker for endometriosis and this genotype may have interactions with age- and hormone-related factors on the development of endometriosis.
|
29109095 |
2018 |
|
rs1801516
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five variants were previously reported to confer risk of various malignant or benign tumors (rs78378222 in TP53, rs10069690 in TERT, rs1800057 and rs1801516 in ATM, and rs7907606 at OBFC1) and four signals are located at established risk loci for hormone-related traits (endometriosis and breast cancer) at 1q36.12 (CDC42/WNT4), 2p25.1 (GREB1), 20p12.3 (MCM8), and 6q26.2 (SYNE1/ESR1).
|
30194396 |
2018 |
|
rs2475335
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Cross-disease GWAS meta-analysis highlighted 13 distinct loci associated at P ≤ 10<sup>-5</sup> with both endometriosis and endometrial cancer, with one locus (SNP rs2475335) located within PTPRD associated at a genomewide significant level (P = 4.9 × 10<sup>-8</sup> , OR = 1.11, 95% CI = 1.07-1.15).
|
29608257 |
2018 |
|
rs3918242
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, we performed two meta-analyses for MMP9 rs3918242 polymorphism in endometriosis/adenomyosis and preeclampsia but found no association with either disorder.
|
29309889 |
2018 |
|
rs4246215
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The genotypes of FEN1 rs174538, but not those of rs4246215, were differently distributed between the endometriosis and control groups.
|
29109095 |
2018 |
|
rs4980524
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G/G allele of STIP1 SNP rs4980524 is associated with the increased expression of STIP1 and MMP9 in endometriosis.
|
29673672 |
2018 |
|
rs78378222
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five variants were previously reported to confer risk of various malignant or benign tumors (rs78378222 in TP53, rs10069690 in TERT, rs1800057 and rs1801516 in ATM, and rs7907606 at OBFC1) and four signals are located at established risk loci for hormone-related traits (endometriosis and breast cancer) at 1q36.12 (CDC42/WNT4), 2p25.1 (GREB1), 20p12.3 (MCM8), and 6q26.2 (SYNE1/ESR1).
|
30194396 |
2018 |
|
rs7907606
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Five variants were previously reported to confer risk of various malignant or benign tumors (rs78378222 in TP53, rs10069690 in TERT, rs1800057 and rs1801516 in ATM, and rs7907606 at OBFC1) and four signals are located at established risk loci for hormone-related traits (endometriosis and breast cancer) at 1q36.12 (CDC42/WNT4), 2p25.1 (GREB1), 20p12.3 (MCM8), and 6q26.2 (SYNE1/ESR1).
|
30194396 |
2018 |
|
rs80111889
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A known dysmenorrhea signal near NGF replicated in our data (rs12030576; P = 1.1 × 10<sup>-19</sup>) and was associated with RP4-663N10.1 expression, a putative lncRNA enhancer of NGF, while a novel dysmenorrhea signal in the IL1 locus (rs80111889; P = 1.9 × 10<sup>-16</sup>) contained SNPs previously associated with endometriosis, and GWAS SNPs were most significantly associated with IL1A expression.
|
29855537 |
2018 |
|
rs11031006
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found a genetic association between rs11031006 (FSHB) SNP and endometriosis.
|
28901453 |
2017 |
|
rs11651755
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As rs11651755 in HNF1B modified both the ovarian cancer risk and also the risk for endometriosis, HNF1B may be causally involved in the pathogenetic pathway leading from endometriosis to ovarian cancer.
|
28214017 |
2017 |
|
rs1799964
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No significant difference was observed in genotypic or allelic frequencies between control and endometriosis groups for rs498679 (TLR4 gene), rs1799964 (TNF-α gene), rs3024496 (IL-10 gene), neither when comparing endometriosis subgroups (I-II versus III-IV).
|
28470452 |
2017 |