|
rs1799793
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate the relationship between DNA repair and NHL we analysed polymorphisms in XPD (R156R, D312N, K751Q) using DNA collected in a UK population-based case-control study of lymphoma.
|
19736055 |
2009 |
|
rs13181
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To investigate the relationship between DNA repair and NHL we analysed polymorphisms in XPD (R156R, D312N, K751Q) using DNA collected in a UK population-based case-control study of lymphoma.
|
19736055 |
2009 |
|
rs17655
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results suggest that the rs1800975, rs17655 and rs1805087 SNPs in DNA repair and synthesis of genes do not seem to play a major role in lymphoma susceptibility.
|
23818366 |
2013 |
|
rs867329357
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Herein we performed a case-control study evaluating the influence of three single nucleotide polymorphisms (SNPs) in XPA, ERCC5 and MTR [rs1800975 (G-4A), rs17655 (Asp1104His) and rs1805087 (A2756G), respectively] in lymphoma risk.
|
23818366 |
2013 |
|
rs267601394
|
|
A |
0.720 |
GeneticVariation |
CLINVAR |
Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma.
|
24563539 |
2014 |
|
rs267601394
|
|
G |
0.720 |
GeneticVariation |
CLINVAR |
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.
|
23023262 |
2012 |
|
rs267601394
|
|
|
0.720 |
GeneticVariation |
BEFREE |
As EZH2 mutations often coincide with other mutations in lymphoma, we combined the expression of EZH2(Y641F) by crossing these transgenic mice with Eµ-Myc transgenic mice.
|
24802772 |
2014 |
|
rs267601394
|
|
|
0.720 |
GeneticVariation |
BEFREE |
These results suggest that Ezh2(Y641F) induces lymphoma and melanoma through a vast reorganization of chromatin structure, inducing both repression and activation of polycomb-regulated loci.
|
27135738 |
2016 |
|
rs267601394
|
|
A |
0.720 |
GeneticVariation |
CLINVAR |
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.
|
23023262 |
2012 |
|
rs1057519833
|
|
|
0.710 |
GeneticVariation |
BEFREE |
Herein, we identify mutation of EZH2 A677 to a glycine (A677G) among lymphoma cell lines and primary tumor specimens.
|
22323599 |
2012 |
|
rs1057519833
|
|
C |
0.710 |
GeneticVariation |
CLINVAR |
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.
|
23023262 |
2012 |
|
rs267601395
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.
|
23023262 |
2012 |
|
rs267601395
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.
|
23023262 |
2012 |
|
rs121913105
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Constitutive phosphorylation of c-Cbl by the K650M mutant appeared to be related to the intracellular retention of the receptor.
|
17509076 |
2007 |
|
rs121913482
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Internalization of the R248C and Y373C mutant receptors, which form stable disulfide-bonded dimers at the cell surface was less efficient than the wild-type, whereas ubiquitylation was markedly increased but apparently independent of the E3 ubiquitin-ligase casitas B-lineage lymphoma (c-Cbl).
|
17509076 |
2007 |
|
rs121913485
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Internalization of the R248C and Y373C mutant receptors, which form stable disulfide-bonded dimers at the cell surface was less efficient than the wild-type, whereas ubiquitylation was markedly increased but apparently independent of the E3 ubiquitin-ligase casitas B-lineage lymphoma (c-Cbl).
|
17509076 |
2007 |
|
rs2274084
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We investigated GJB2 rs2274084 polymorphism in three types of tumors, including nasophoryngeal carcinoma (NPC), gastric cancer (GC) and lymphoma.
|
29103018 |
2018 |
|
rs995922697
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Data from two population-based, case-control studies of lymphoma in the UK (700 cases and 915 controls) and USA (1593 cases and 2517 controls) were pooled to analyze polymorphisms in genes involved in the oxidative stress response (SOD2 Val16Ala, CAT C-262T and GPX1 Pro197Leu).
|
16956821 |
2006 |
|
rs1695
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Pooled results showed that the GSTT1 null polymorphism might increase the risk of lymphoma (odds ratio [OR] 2.26, 95% confidence interval [CI] 1.20, 4.24; p = 0.01; random-effects model), whereas the impact of GSTM1 and GSTP1 Ile105Val polymorphisms was not significant.
|
22734843 |
2013 |
|
rs9461776
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The significant relationship between rs2071286 and rs9461776 MAF and the increased risk for NHL, suggests their use as non-invasive markers to categorize patients at risk of lymphoma.
|
29069725 |
2017 |
|
rs9268853
|
|
C |
0.800 |
GeneticVariation |
GWASCAT |
Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies.
|
23349640 |
2013 |
|
rs9268853
|
|
C |
0.800 |
GeneticVariation |
GWASDB |
Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies.
|
23349640 |
2013 |
|
rs2395185
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We replicated a strong risk association in non-Hispanic White males with rs2395185, a protective marker for lymphoma.
|
24707947 |
2015 |
|
rs2304240
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The ADAM19 rs11466782 SNP was associated with an increased risk of lymphoma (OR, 1.73; 95% CI, 1.28-2.35; Padditive=0.0004), and the ICAM3 rs2304240 (OR, 0.67; 95% CI, 0.52-0.86; Padditive=0.002) and the PTGDR rs708486 SNPs (OR, 0.75; 95% CI, 0.63-0.90; Padditive=0.002) were associated with reduced risk of lymphoma.
|
21239057 |
2011 |
|
rs121913503
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The test evaluates the expression of 20 genes, including 17 markers relevant to T-cell immunology and lymphoma biopathology, one EBV-related transcript, and variants of RHOA (G17V) and IDH2 (R172K/T).
|
31488561 |
2019 |