Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs10500279
rs10500279
RYR1
0.700 GeneticVariation GWASDB Common variants in RYR1 are associated with left ventricular hypertrophy assessed by electrocardiogram. 21828061

2012
dbSNP: rs1060501439
rs1060501439
MYH7
A 0.700 GeneticVariation CLINVAR

dbSNP: rs121908596
rs121908596
MAP2K1
T 0.700 GeneticVariation CLINVAR Mutation and phenotypic spectrum in patients with cardio-facio-cutaneous and Costello syndrome. 18042262

2008
dbSNP: rs1436109
rs1436109
NCAM1
0.700 GeneticVariation GWASCAT Genetic variation in NCAM1 contributes to left ventricular wall thickness in hypertensive families. 21212386

2011
dbSNP: rs2071090
rs2071090
RYR1
0.700 GeneticVariation GWASDB Common variants in RYR1 are associated with left ventricular hypertrophy assessed by electrocardiogram. 21828061

2012
dbSNP: rs2960321
rs2960321
RYR1
0.700 GeneticVariation GWASDB Common variants in RYR1 are associated with left ventricular hypertrophy assessed by electrocardiogram. 21828061

2012
dbSNP: rs768079285
rs768079285
NEBL
A 0.700 GeneticVariation CLINVAR

dbSNP: rs699
rs699
AGT
0.060 GeneticVariation BEFREE Angiotensinogen M235T and T174M polymorphisms have individually been associated with elevated levels of plasma angiotensinogen, hypertension, and left ventricular hypertrophy. 17145981

2007
dbSNP: rs699
rs699
AGT
0.060 GeneticVariation BEFREE There are controversies concerning the association of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism with left ventricular hypertrophy (LVH), and the unclear association between angiotensinogen (ATG) M235T polymorphism and LVH. 10646957

2000
dbSNP: rs699
rs699
AGT
0.060 GeneticVariation BEFREE These results suggest an association of combined angiotensin I-converting enzyme gene I/D polymorphism genotypes, and angiotensinogen gene M235T polymorphism genotypes with left ventricular hypertrophy due to long-term athletic training. 11737220

2001
dbSNP: rs699
rs699
AGT
0.060 GeneticVariation BEFREE Polymorphism of the AGT M235T gene but not ACE I/D gene is associated with greater LVMi and relative wall thickness, indicating more concentric LVH, in Chinese peritoneal dialysis patients. 12675870

2003
dbSNP: rs699
rs699
AGT
0.060 GeneticVariation BEFREE The angiotensinogen T174M and M235T and the AT1-receptor A1166C polymorphisms were related to the change in LVH during antihypertensive treatment with an AT1-receptor antagonist; of these angiotensinogen T174M was the most powerful. 11910301

2002
dbSNP: rs699
rs699
AGT
0.060 GeneticVariation BEFREE Angiotensinogen gene M235T polymorphism is associated with the variability in left ventricular hypertrophy induced by endurance training, with athletes homozygous for the T allele having the largest hearts. 10440164

1999
dbSNP: rs1267969615
rs1267969615
ACE
0.050 GeneticVariation BEFREE Angiotensinogen gene M235T polymorphism is associated with the variability in left ventricular hypertrophy induced by endurance training, with athletes homozygous for the T allele having the largest hearts. 10440164

1999
dbSNP: rs1267969615
rs1267969615
ACE
0.050 GeneticVariation BEFREE Polymorphism of the AGT M235T gene but not ACE I/D gene is associated with greater LVMi and relative wall thickness, indicating more concentric LVH, in Chinese peritoneal dialysis patients. 12675870

2003
dbSNP: rs1267969615
rs1267969615
ACE
0.050 GeneticVariation BEFREE There are controversies concerning the association of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism with left ventricular hypertrophy (LVH), and the unclear association between angiotensinogen (ATG) M235T polymorphism and LVH. 10646957

2000
dbSNP: rs1267969615
rs1267969615
ACE
0.050 GeneticVariation BEFREE These results suggest an association of combined angiotensin I-converting enzyme gene I/D polymorphism genotypes, and angiotensinogen gene M235T polymorphism genotypes with left ventricular hypertrophy due to long-term athletic training. 11737220

2001
dbSNP: rs1267969615
rs1267969615
ACE
0.050 GeneticVariation BEFREE The angiotensinogen T174M and M235T and the AT1-receptor A1166C polymorphisms were related to the change in LVH during antihypertensive treatment with an AT1-receptor antagonist; of these angiotensinogen T174M was the most powerful. 11910301

2002
dbSNP: rs397516005
rs397516005
MYBPC3
0.040 GeneticVariation BEFREE Concentrations of branched chain amino acids, triglycerides and ether phospholipids were increased in mutation carriers with hypertrophy as compared to controls and non-hypertrophic mutation carriers, and correlated with echocardiographic LVH and signs of diastolic and systolic dysfunction in subjects with the MYBPC3-Q1061X mutation. 26267065

2015
dbSNP: rs397516005
rs397516005
MYBPC3
0.040 GeneticVariation BEFREE We studied 140 carriers (G+) of the TPM1-Asp175Asn or MYBPC3-Gln1061X pathogenic variants for HCM: The G+/LVH+ group (n = 98) consisted of mutation carriers with LVH and the G+/LVH- group (n = 42) without LVH. 30497761

2019
dbSNP: rs397516005
rs397516005
MYBPC3
0.040 GeneticVariation BEFREE Our objective was to measure the length of mitral valve leaflets by cardiovascular magnetic resonance (CMR) in subjects with HCM caused by a Finnish founder mutation in the myosin-binding protein C gene (MYBPC3-Q1061X), carriers of the same mutation without left ventricular hypertrophy, as well as in unselected consecutive patients with HCM, and respective controls. 27259862

2016
dbSNP: rs397516005
rs397516005
MYBPC3
0.040 GeneticVariation BEFREE Septal convexity was significantly increased in subjects with the MYBPC3-Q1061X mutation and LVH (n = 32) compared to controls (11.4 ± 4.3 vs 2.7 ± 3.2 mm, P < 0.001). 30976029

2019
dbSNP: rs1801253
rs1801253
ADRB1
0.030 GeneticVariation BEFREE Our data demonstrate that both Gly389Arg and Ser49Gly polymorphisms have very moderate influence on the risk of left ventricular hypertrophy and atrial fibrillation with no statistically significant effects on cardiac function and the development of cardiovascular complications. 24982877

2014
dbSNP: rs1801253
rs1801253
ADRB1
0.030 GeneticVariation BEFREE Our findings show that the Arg389Gly polymorphism of the ADRB1 gene confers higher risk of left ventricular hypertrophy in human essential hypertension. 18298953

2008
dbSNP: rs1801253
rs1801253
ADRB1
0.030 GeneticVariation BEFREE The data suggest an association between the beta1AR Arg389Gly polymorphism and LVH, particularly the septal hypertrophy. 20731869

2010