|
rs1060501439
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs397516037
|
|
A |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs768079285
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs869312687
|
|
G |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs4762
|
|
|
0.030 |
GeneticVariation |
BEFREE |
1.The relationship between the angiotensinogen (AGT) T174M, angiotensin converting enzyme (ACE) insertion/deletion (I/D) and the angiotensin II type 1 receptor (AT1) genetic markers and left ventricular hypertrophy was examined in normal subjects and those with aortic stenosis.2.
|
8800593 |
1996 |
|
rs5522
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Left ventricular hypertrophy (LVH) was more prevalent in G carriers than AA homozygous for rs5522 but not for rs2070951 in RHTN.
|
26049084 |
2016 |
|
rs2070951
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Left ventricular hypertrophy (LVH) was more prevalent in G carriers than AA homozygous for rs5522 but not for rs2070951 in RHTN.
|
26049084 |
2016 |
|
rs28935197
|
|
|
0.010 |
GeneticVariation |
BEFREE |
N215S patients showed later symptom onset (males: p< 0.0001, females: p<0.03), later development of left ventricular hypertrophy (LVH) (median survival without LVH: 41 (non-N215S) vs. 64 (N215S) years, p< 0.0001), later development of proteinuria (median survival without proteinuria 43 (non-N215S) vs 71 years (N215S), p< 0.0001), later occurrence of cerebrovascular events (stroke/ Transient Ischaemic Attacks (TIA); median survival without stroke: 74 years (non-N215S) vs. not reached (N215S), p< 0.02), later decline in renal function to GFR <60 ml/min/1.73m2 (median survival: 56 (non-N215S) vs. 72 (N215S) years, p< 0.01), and greater overall survival (median survival 81 (N215S) vs. 66 (non-N215S) years, p< 0.0006).
|
29621274 |
2018 |
|
rs1799983
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A common variant of the eNOS gene (E298D) is an independent risk factor for left ventricular hypertrophy in human essential hypertension.
|
19132956 |
2009 |
|
rs5186
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 176 hypertensive patients with a diagnosis of HFpEF were divided to cases with LVH and controls without. rs4343 and rs4291 of angiotensin-converting enzyme (ACE) and rs5186 of angiotensin receptor type 1 were genotyped using PCR-RFLP method.
|
28513230 |
2017 |
|
rs2074192
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ACE2 tagSNPs rs2074192 and rs2106809 as well as major haplotypes CCGC and TCGT may serve as novel risk markers for LVH in hypertensive patients.
|
30917908 |
2019 |
|
rs2106809
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ACE2 tagSNPs rs2074192 and rs2106809 as well as major haplotypes CCGC and TCGT may serve as novel risk markers for LVH in hypertensive patients.
|
30917908 |
2019 |
|
rs699
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Angiotensinogen M235T and T174M polymorphisms have individually been associated with elevated levels of plasma angiotensinogen, hypertension, and left ventricular hypertrophy.
|
17145981 |
2007 |
|
rs699
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Angiotensinogen gene M235T polymorphism is associated with the variability in left ventricular hypertrophy induced by endurance training, with athletes homozygous for the T allele having the largest hearts.
|
10440164 |
1999 |
|
rs1267969615
|
|
|
0.050 |
GeneticVariation |
BEFREE |
Angiotensinogen gene M235T polymorphism is associated with the variability in left ventricular hypertrophy induced by endurance training, with athletes homozygous for the T allele having the largest hearts.
|
10440164 |
1999 |
|
rs4762
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Angiotensinogen M235T and T174M polymorphisms have individually been associated with elevated levels of plasma angiotensinogen, hypertension, and left ventricular hypertrophy.
|
17145981 |
2007 |
|
rs10500279
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Common variants in RYR1 are associated with left ventricular hypertrophy assessed by electrocardiogram.
|
21828061 |
2012 |
|
rs2071090
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Common variants in RYR1 are associated with left ventricular hypertrophy assessed by electrocardiogram.
|
21828061 |
2012 |
|
rs2960321
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Common variants in RYR1 are associated with left ventricular hypertrophy assessed by electrocardiogram.
|
21828061 |
2012 |
|
rs397516005
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Concentrations of branched chain amino acids, triglycerides and ether phospholipids were increased in mutation carriers with hypertrophy as compared to controls and non-hypertrophic mutation carriers, and correlated with echocardiographic LVH and signs of diastolic and systolic dysfunction in subjects with the MYBPC3-Q1061X mutation.
|
26267065 |
2015 |
|
rs76992529
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Electrocardiographic voltages meet the criteria for LVH in one quarter of patients with ATTR V122I cardiac amyloidosis.
|
22795285 |
2012 |
|
rs148158093
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Fabry disease presenting as apical left ventricular hypertrophy in a patient carrying the missense mutation R118C.
|
24661928 |
2014 |
|
rs1436109
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genetic variation in NCAM1 contributes to left ventricular wall thickness in hypertensive families.
|
21212386 |
2011 |
|
rs5443
|
|
|
0.030 |
GeneticVariation |
BEFREE |
GNB3 825 C>T is likely to be a significant risk factor for LVH but not for EH in the Emirati population, thereby strengthening the view that LVH is genetically a separate clinical entity.
|
15614196 |
2005 |
|
rs1042714
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a prospective follow-up study we screened 970 hypertensive patients of Caucasian descent for the Gly16Arg, Gln27Glu, and Thr164Ile beta(2)AR polymorphisms and left ventricular echocardiographic hypertrophy and assigned selected patients to enalapril or atenolol to assess left ventricular hypertrophy regression after 2-year follow-up.
|
17178264 |
2006 |