Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs1267969615
rs1267969615
ACE
0.050 GeneticVariation BEFREE Angiotensinogen gene M235T polymorphism is associated with the variability in left ventricular hypertrophy induced by endurance training, with athletes homozygous for the T allele having the largest hearts. 10440164

1999

dbSNP: rs1267969615
rs1267969615
ACE
0.050 GeneticVariation BEFREE Polymorphism of the AGT M235T gene but not ACE I/D gene is associated with greater LVMi and relative wall thickness, indicating more concentric LVH, in Chinese peritoneal dialysis patients. 12675870

2003

dbSNP: rs1267969615
rs1267969615
ACE
0.050 GeneticVariation BEFREE There are controversies concerning the association of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism with left ventricular hypertrophy (LVH), and the unclear association between angiotensinogen (ATG) M235T polymorphism and LVH. 10646957

2000

dbSNP: rs1267969615
rs1267969615
ACE
0.050 GeneticVariation BEFREE These results suggest an association of combined angiotensin I-converting enzyme gene I/D polymorphism genotypes, and angiotensinogen gene M235T polymorphism genotypes with left ventricular hypertrophy due to long-term athletic training. 11737220

2001

dbSNP: rs1267969615
rs1267969615
ACE
0.050 GeneticVariation BEFREE The angiotensinogen T174M and M235T and the AT1-receptor A1166C polymorphisms were related to the change in LVH during antihypertensive treatment with an AT1-receptor antagonist; of these angiotensinogen T174M was the most powerful. 11910301

2002

dbSNP: rs1277204441
rs1277204441
ACE
0.010 GeneticVariation BEFREE In a prospective follow-up study we screened 970 hypertensive patients of Caucasian descent for the Gly16Arg, Gln27Glu, and Thr164Ile beta(2)AR polymorphisms and left ventricular echocardiographic hypertrophy and assigned selected patients to enalapril or atenolol to assess left ventricular hypertrophy regression after 2-year follow-up. 17178264

2006

dbSNP: rs1415088003
rs1415088003
ACE
0.010 GeneticVariation BEFREE In conclusion, our results suggest an association between LVH and the C825T allele of the G-protein beta3 subunit gene. 11768721

2001

dbSNP: rs4291
rs4291
ACE
0.010 GeneticVariation BEFREE Increased ACE activity explains the significant association of rs4343 and rs4291 polymorphisms with LVH in the carriers. 28513230

2017

dbSNP: rs4343
rs4343
ACE
0.010 GeneticVariation BEFREE Increased ACE activity explains the significant association of rs4343 and rs4291 polymorphisms with LVH in the carriers. 28513230

2017

dbSNP: rs2074192
rs2074192
0.010 GeneticVariation BEFREE ACE2 tagSNPs rs2074192 and rs2106809 as well as major haplotypes CCGC and TCGT may serve as novel risk markers for LVH in hypertensive patients. 30917908

2019

dbSNP: rs2106809
rs2106809
0.010 GeneticVariation BEFREE ACE2 tagSNPs rs2074192 and rs2106809 as well as major haplotypes CCGC and TCGT may serve as novel risk markers for LVH in hypertensive patients. 30917908

2019

dbSNP: rs755492182
rs755492182
0.010 GeneticVariation BEFREE We identified a rare c.740C>T (p.T247M) mutation in ACTN2, encoding α-actinin 2 in a HCM patient, who presented with left ventricular hypertrophy, outflow tract obstruction, and atrial fibrillation. 31680489

2019

dbSNP: rs1801253
rs1801253
0.030 GeneticVariation BEFREE Our data demonstrate that both Gly389Arg and Ser49Gly polymorphisms have very moderate influence on the risk of left ventricular hypertrophy and atrial fibrillation with no statistically significant effects on cardiac function and the development of cardiovascular complications. 24982877

2014

dbSNP: rs1801253
rs1801253
0.030 GeneticVariation BEFREE Our findings show that the Arg389Gly polymorphism of the ADRB1 gene confers higher risk of left ventricular hypertrophy in human essential hypertension. 18298953

2008

dbSNP: rs1801253
rs1801253
0.030 GeneticVariation BEFREE The data suggest an association between the beta1AR Arg389Gly polymorphism and LVH, particularly the septal hypertrophy. 20731869

2010

dbSNP: rs1801252
rs1801252
0.010 GeneticVariation BEFREE Our data demonstrate that both Gly389Arg and Ser49Gly polymorphisms have very moderate influence on the risk of left ventricular hypertrophy and atrial fibrillation with no statistically significant effects on cardiac function and the development of cardiovascular complications. 24982877

2014

dbSNP: rs1042714
rs1042714
0.010 GeneticVariation BEFREE In a prospective follow-up study we screened 970 hypertensive patients of Caucasian descent for the Gly16Arg, Gln27Glu, and Thr164Ile beta(2)AR polymorphisms and left ventricular echocardiographic hypertrophy and assigned selected patients to enalapril or atenolol to assess left ventricular hypertrophy regression after 2-year follow-up. 17178264

2006

dbSNP: rs1800888
rs1800888
0.010 GeneticVariation BEFREE In a prospective follow-up study we screened 970 hypertensive patients of Caucasian descent for the Gly16Arg, Gln27Glu, and Thr164Ile beta(2)AR polymorphisms and left ventricular echocardiographic hypertrophy and assigned selected patients to enalapril or atenolol to assess left ventricular hypertrophy regression after 2-year follow-up. 17178264

2006

dbSNP: rs699
rs699
AGT
0.060 GeneticVariation BEFREE Angiotensinogen M235T and T174M polymorphisms have individually been associated with elevated levels of plasma angiotensinogen, hypertension, and left ventricular hypertrophy. 17145981

2007

dbSNP: rs699
rs699
AGT
0.060 GeneticVariation BEFREE There are controversies concerning the association of angiotensin-converting enzyme (ACE) insertion/deletion (I/D) polymorphism with left ventricular hypertrophy (LVH), and the unclear association between angiotensinogen (ATG) M235T polymorphism and LVH. 10646957

2000

dbSNP: rs699
rs699
AGT
0.060 GeneticVariation BEFREE These results suggest an association of combined angiotensin I-converting enzyme gene I/D polymorphism genotypes, and angiotensinogen gene M235T polymorphism genotypes with left ventricular hypertrophy due to long-term athletic training. 11737220

2001

dbSNP: rs699
rs699
AGT
0.060 GeneticVariation BEFREE Polymorphism of the AGT M235T gene but not ACE I/D gene is associated with greater LVMi and relative wall thickness, indicating more concentric LVH, in Chinese peritoneal dialysis patients. 12675870

2003

dbSNP: rs699
rs699
AGT
0.060 GeneticVariation BEFREE The angiotensinogen T174M and M235T and the AT1-receptor A1166C polymorphisms were related to the change in LVH during antihypertensive treatment with an AT1-receptor antagonist; of these angiotensinogen T174M was the most powerful. 11910301

2002

dbSNP: rs699
rs699
AGT
0.060 GeneticVariation BEFREE Angiotensinogen gene M235T polymorphism is associated with the variability in left ventricular hypertrophy induced by endurance training, with athletes homozygous for the T allele having the largest hearts. 10440164

1999

dbSNP: rs4762
rs4762
AGT
0.030 GeneticVariation BEFREE Angiotensinogen M235T and T174M polymorphisms have individually been associated with elevated levels of plasma angiotensinogen, hypertension, and left ventricular hypertrophy. 17145981

2007