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rs11549465
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The distribution differences of gene frequencies for rs11549465, rs11549467 and rs1957757 in HIF1A single nucleotide gene polymorphisms for LVH (+) and LVH (-) were statistically significant (p<0.05).
|
31599436 |
2019 |
|
rs11549467
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The distribution differences of gene frequencies for rs11549465, rs11549467 and rs1957757 in HIF1A single nucleotide gene polymorphisms for LVH (+) and LVH (-) were statistically significant (p<0.05).
|
31599436 |
2019 |
|
rs1957757
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The distribution differences of gene frequencies for rs11549465, rs11549467 and rs1957757 in HIF1A single nucleotide gene polymorphisms for LVH (+) and LVH (-) were statistically significant (p<0.05).
|
31599436 |
2019 |
|
rs2074192
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ACE2 tagSNPs rs2074192 and rs2106809 as well as major haplotypes CCGC and TCGT may serve as novel risk markers for LVH in hypertensive patients.
|
30917908 |
2019 |
|
rs2106809
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ACE2 tagSNPs rs2074192 and rs2106809 as well as major haplotypes CCGC and TCGT may serve as novel risk markers for LVH in hypertensive patients.
|
30917908 |
2019 |
|
rs28933979
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Kaplan-Meier analysis demonstrated a significantly higher probability of the composite endpoint in the non-Val30Met group than in the Val30Met group (log-rank test: P = 0.002) and in patients with left ventricular hypertrophy than in patients without left ventricular hypertrophy (log-rank test: P < 0.001).
|
30284755 |
2019 |
|
rs755492182
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified a rare c.740C>T (p.T247M) mutation in ACTN2, encoding α-actinin 2 in a HCM patient, who presented with left ventricular hypertrophy, outflow tract obstruction, and atrial fibrillation.
|
31680489 |
2019 |
|
rs28935197
|
|
|
0.010 |
GeneticVariation |
BEFREE |
N215S patients showed later symptom onset (males: p< 0.0001, females: p<0.03), later development of left ventricular hypertrophy (LVH) (median survival without LVH: 41 (non-N215S) vs. 64 (N215S) years, p< 0.0001), later development of proteinuria (median survival without proteinuria 43 (non-N215S) vs 71 years (N215S), p< 0.0001), later occurrence of cerebrovascular events (stroke/ Transient Ischaemic Attacks (TIA); median survival without stroke: 74 years (non-N215S) vs. not reached (N215S), p< 0.02), later decline in renal function to GFR <60 ml/min/1.73m2 (median survival: 56 (non-N215S) vs. 72 (N215S) years, p< 0.01), and greater overall survival (median survival 81 (N215S) vs. 66 (non-N215S) years, p< 0.0006).
|
29621274 |
2018 |
|
rs861539
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The XRCC3 241Thr/Met genotype was more frequent in the LVH (+) group than in the LVH (-) group (42.3 vs. 13.7%, χ2 = 7.85, p = 0.0051).
|
29626209 |
2018 |
|
rs1050606
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the luciferase experiment, ANXA5 rs1050606 had the most promoter activity in myocardial cells (P < .001).These results showed that ANXA5 rs1050606 was significantly associated with LVH in Chinese EH patients, likely via influencing ANXA5 expression in serum and in myocardial cells.
|
29095261 |
2017 |
|
rs1349963459
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to test the association between a functional polymorphism Glu37Asp (rs2296545) of the renalase gene and left ventricular hypertrophy in a large cohort of patients with aortic stenosis.
|
29065134 |
2017 |
|
rs2073618
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Thalassemia patients having minor allele of OPG rs2073618, RANK rs75404003 and RANKL rs9594782 SNPs were at high risk for LVH as suggested by high odds ratio of 2.470, 3.783, and 2.148, respectively; however, none of the SNPs tested were statistically significantly associated after applying Bonferroni corrections for multiple testing adjustment.
|
28244588 |
2017 |
|
rs2296545
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to test the association between a functional polymorphism Glu37Asp (rs2296545) of the renalase gene and left ventricular hypertrophy in a large cohort of patients with aortic stenosis.
|
29065134 |
2017 |
|
rs2296545
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of this study was to test the association between a functional polymorphism Glu37Asp (rs2296545) of the renalase gene and left ventricular hypertrophy in a large cohort of patients with aortic stenosis.
|
29065134 |
2017 |
|
rs4291
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Increased ACE activity explains the significant association of rs4343 and rs4291 polymorphisms with LVH in the carriers.
|
28513230 |
2017 |
|
rs4343
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Increased ACE activity explains the significant association of rs4343 and rs4291 polymorphisms with LVH in the carriers.
|
28513230 |
2017 |
|
rs5186
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A total of 176 hypertensive patients with a diagnosis of HFpEF were divided to cases with LVH and controls without. rs4343 and rs4291 of angiotensin-converting enzyme (ACE) and rs5186 of angiotensin receptor type 1 were genotyped using PCR-RFLP method.
|
28513230 |
2017 |
|
rs75404003
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Thalassemia patients having minor allele of OPG rs2073618, RANK rs75404003 and RANKL rs9594782 SNPs were at high risk for LVH as suggested by high odds ratio of 2.470, 3.783, and 2.148, respectively; however, none of the SNPs tested were statistically significantly associated after applying Bonferroni corrections for multiple testing adjustment.
|
28244588 |
2017 |
|
rs9594782
|
|
|
0.010 |
GeneticVariation |
BEFREE |
OPG rs2073618, RANK rs75404003, and RANKL rs9594782 SNPs may predispose LVH in thalassemia patients.
|
28244588 |
2017 |
|
rs2070951
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Left ventricular hypertrophy (LVH) was more prevalent in G carriers than AA homozygous for rs5522 but not for rs2070951 in RHTN.
|
26049084 |
2016 |
|
rs238234
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results provide evidence that the rs238234 GG genotype in the coding region of CAMTA2 may increase the risk of LVH by affecting the activation of Nkx2.5-dependent transcription.
|
26886562 |
2016 |
|
rs5522
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Left ventricular hypertrophy (LVH) was more prevalent in G carriers than AA homozygous for rs5522 but not for rs2070951 in RHTN.
|
26049084 |
2016 |
|
rs17168525
|
|
|
0.010 |
GeneticVariation |
BEFREE |
No significant association between the variant rs17168525 and left ventricular hypertrophy in hypertensive patients in a Han Chinese population (P>0.05).
|
26274321 |
2015 |
|
rs1799998
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Some studies have focused on the relationship between -344C/T polymorphism (rs1799998) in the CYP11B2 gene and LVH, but the results are controversial.
|
25208931 |
2015 |
|
rs4129218
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study suggests that rs4129218 on chromosome 12 showed consistent tendency of possibly related loci for LVH independent of ethnic background.
|
25927456 |
2015 |