rs1217691063
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, we have demonstrated that the rare TT genotype of the C677T polymorphism in the MTHFR gene is associated with increased risk of osteoporotic fractures in women and a weak predictor of lumbar spine BMD.
|
15300362 |
2005 |
rs1800629
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated the association between a G-308A polymorphism (rs1800629) at the TNFA locus and osteoporosis phenotypes in 4306 older women participating in the Study of Osteoporotic Fractures.
|
15797957 |
2005 |
rs1213308971
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the associations between the Glu298Asp polymorphism of NOS3, indices of bone strength, and the incidence of fracture among 6691 women aged 65 years and older enrolled in the Study of Osteoporotic Fractures.
|
16503213 |
2006 |
rs1427938321
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the associations between the Glu298Asp polymorphism of NOS3, indices of bone strength, and the incidence of fracture among 6691 women aged 65 years and older enrolled in the Study of Osteoporotic Fractures.
|
16503213 |
2006 |
rs1799983
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the associations between the Glu298Asp polymorphism of NOS3, indices of bone strength, and the incidence of fracture among 6691 women aged 65 years and older enrolled in the Study of Osteoporotic Fractures.
|
16503213 |
2006 |
rs281865264
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the associations between the Glu298Asp polymorphism of NOS3, indices of bone strength, and the incidence of fracture among 6691 women aged 65 years and older enrolled in the Study of Osteoporotic Fractures.
|
16503213 |
2006 |
rs876657777
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the associations between the Glu298Asp polymorphism of NOS3, indices of bone strength, and the incidence of fracture among 6691 women aged 65 years and older enrolled in the Study of Osteoporotic Fractures.
|
16503213 |
2006 |
rs1217691063
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, the C677T polymorphism of the MTHFR gene does not appear to be associated with the overall risk of osteoporotic fractures.
|
17712717 |
2007 |
rs2073618
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We investigated the association between a Lys3Asn polymorphism in the OPG gene and bone mineral density (BMD), and the risk of fracture in 6695 women aged 65 yr and older participating in the Study of Osteoporotic Fractures.
|
18319311 |
2008 |
rs3736228
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A non-synonymous SNP in the LRP5 gene was associated with decreased bone mineral density (rs3736228, p=6.3x10(-12) for lumbar spine and p=1.9x10(-4) for femoral neck) and an increased risk of both osteoporotic fractures (odds ratio [OR] 1.3, 95% CI 1.09-1.52, p=0.002) and osteoporosis (OR 1.3, 1.08-1.63, p=0.008).
|
18455228 |
2008 |
rs13182402
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that a SNP, rs13182402 within the ALDH7A1 gene on chromosome 5q31, was strongly associated with OF with evidence combined GWAS and replication studies (P = 2.08x10(-9), odds ratio = 2.25).
|
20072603 |
2010 |
rs11898505
|
|
|
0.020 |
GeneticVariation |
BEFREE |
SPTBN1 (rs11898505) and SOST (rs1107748) were associated with osteoporotic fracture.
|
20554715 |
2010 |
rs6469804
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A significant gene-gene interaction for osteoporotic fracture involving rs1107748 in SOST and rs6469804 in OPG gene was identified from generalized multifactor dimensionality reduction analysis.
|
20554715 |
2010 |
rs1107748
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant gene-gene interaction for osteoporotic fracture involving rs1107748 i</span>n SOST and rs6469804 in OPG gene was identified from generalized multifactor dimensionality reduction analysis.
|
20554715 |
2010 |
rs4680
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Catechol-O-methyltransferase (COMT) Val158Met polymorphism and risk of osteoporotic fracture.
|
21691708 |
2012 |
rs11898505
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Genetic (rs11898505) and non-genetic factors (age, number of falls in a year and L1-4 BMD) could work in concert to contribute to the risk of osteoporotic fractures.
|
22798246 |
2013 |
rs12475342
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified one SNP in TNFRSF11B (rs3102734), three SNPs in ESR1 (rs9397448, rs2234693, and rs1643821), two SNPs in LRP4 (rs17790156 and rs898604), and four SNPs in SPTBN1 (rs2971886, rs2941583, rs2941584, and rs12475342) were associated with all of the broadly defined osteoporotic fractures.
|
22807154 |
2012 |
rs1643821
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified one SNP in TNFRSF11B (rs3102734), three SNPs in ESR1 (rs9397448, rs2234693, and rs1643821), two SNPs in LRP4 (rs17790156 and rs898604), and four SNPs in SPTBN1 (rs2971886, rs2941583, rs2941584, and rs12475342) were associated with all of the broadly defined osteoporotic fractures.
|
22807154 |
2012 |
rs17790156
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified one SNP in TNFRSF11B (rs3102734), three SNPs in ESR1 (rs9397448, rs2234693, and rs1643821), two SNPs in LRP4 (rs17790156 and rs898604), and four SNPs in SPTBN1 (rs2971886, rs2941583, rs2941584, and rs12475342) were associated with all of the broadly defined osteoporotic fractures.
|
22807154 |
2012 |
rs2234693
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified one SNP in TNFRSF11B (rs3102734), three SNPs in ESR1 (rs9397448, rs2234693, and rs1643821), two SNPs in LRP4 (rs17790156 and rs898604), and four SNPs in SPTBN1 (rs2971886, rs2941583, rs2941584, and rs12475342) were associated with all of the broadly defined osteoporotic fractures.
|
22807154 |
2012 |
rs2941584
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified one SNP in TNFRSF11B (rs3102734), three SNPs in ESR1 (rs9397448, rs2234693, and rs1643821), two SNPs in LRP4 (rs17790156 and rs898604), and four SNPs in SPTBN1 (rs2971886, rs2941583, rs2941584, and rs12475342) were associated with all of the broadly defined osteoporotic fractures.
|
22807154 |
2012 |
rs3102734
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The most significant polymorphism was rs3102734, with increased risk of osteoporotic fractures (odds ratio, 1.35; 95% confidence interval [CI], 1.17-1.55, Bonferroni p = 2.6 × 10(-4) ).
|
22807154 |
2012 |
rs898604
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified one SNP in TNFRSF11B (rs3102734), three SNPs in ESR1 (rs9397448, rs2234693, and rs1643821), two SNPs in LRP4 (rs17790156 and rs898604), and four SNPs in SPTBN1 (rs2971886, rs2941583, rs2941584, and rs12475342) were associated with all of the broadly defined osteoporotic fractures.
|
22807154 |
2012 |
rs3087456
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Despite increasing bone loss, the rs3087456(G) allele was protective against incident fracture overall (p = 0.002), osteoporotic fracture and hip fracture.
|
23133532 |
2012 |
rs784288
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a combined meta-analysis of a discovery cohort (288 cases and 1139 controls), three hospital based sets in replication stage I (462 cases and 1745 controls), and an independent ethnic group in replication stage II (369 cases and 560 for controls), we identified a new locus associated with OF (rs784288 in the MECOM gene) that showed genome-wide significance (p=3.59×10(-8); OR 1.39).
|
23349225 |
2013 |