|
rs6831280
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>IDUA</i> rs6831280 is associated with BMDs at L2-4 and TH in the elderly Chinese population with SOP and may serve as a marker for the genetic susceptibility to osteoporotic fractures.
|
31275456 |
2019 |
|
rs3736228
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A non-synonymous SNP in the LRP5 gene was associated with decreased bone mineral density (rs3736228, p=6.3x10(-12) for lumbar spine and p=1.9x10(-4) for femoral neck) and an increased risk of both osteoporotic fractures (odds ratio [OR] 1.3, 95% CI 1.09-1.52, p=0.002) and osteoporosis (OR 1.3, 1.08-1.63, p=0.008).
|
18455228 |
2008 |
|
rs1107748
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant gene-gene interaction for osteoporotic fracture involving rs1107748 i</span>n SOST and rs6469804 in OPG gene was identified from generalized multifactor dimensionality reduction analysis.
|
20554715 |
2010 |
|
rs6469804
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A significant gene-gene interaction for osteoporotic fracture involving rs1107748 in SOST and rs6469804 in OPG gene was identified from generalized multifactor dimensionality reduction analysis.
|
20554715 |
2010 |
|
rs6469804
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Among the nine SNPs genotyped, rs6469804 and rs2073618 showed significant associations with both BMD and osteoporotic fractures, while rs3102735 was only associated with BMD in our samples (P < 0.05).
|
28496203 |
2017 |
|
rs2073618
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Among the nine SNPs genotyped, rs6469804 and rs2073618 showed significant associations with both BMD and osteoporotic fractures, while rs3102735 was only associated with BMD in our samples (P < 0.05).
|
28496203 |
2017 |
|
rs3102735
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the nine SNPs genotyped, rs6469804 and rs2073618 showed significant associations with both BMD and osteoporotic fractures, while rs3102735 was only associated with BMD in our samples (P < 0.05).
|
28496203 |
2017 |
|
rs758488397
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both variants associate with low BMD and with osteoporotic fractures. p.Gly496Ala (frequency of 0.105%) shows the strongest association with low BMD at the spine (p = 1.8 × 10(-7) , odds ratio [OR] = 4.61 [95% confidence interval (CI) 2.59, 8.18]), whereas p.Gly703Ser (frequency of 0.050%) is most strongly associated with low BMD at the hip (p = 1.9 × 10(-8) , OR = 9.34 [95% CI 4.28, 20.3]).
|
26235824 |
2016 |
|
rs4680
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Catechol-O-methyltransferase (COMT) Val158Met polymorphism and risk of osteoporotic fracture.
|
21691708 |
2012 |
|
rs3087456
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Despite increasing bone loss, the rs3087456(G) allele was protective against incident fracture overall (p = 0.002), osteoporotic fracture and hip fracture.
|
23133532 |
2012 |
|
rs1982073
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Disease-stratified results yielded that rs1982073 C>T may increase the risk of fracture, OP, and OA under the allele model, but was only significantly related to OP under the dominant model.
|
25501632 |
2016 |
|
rs4342521
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Eight selected variants were tested for association in the complete cohort and 2 of them (rs4342521 and rs10085588) were found significantly associated with lumbar spine BMD and nominally associated with osteoporotic fracture. cis-eQTL analyses of these 2 SNPs, together with SNP rs4727338 (GWAS lead SNP in Estrada et al., Nat Genet.
|
30878523 |
2019 |
|
rs10085588
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Eight selected variants were tested for association in the complete cohort and 2 of them (rs4342521 and rs10085588) were found significantly associated with lumbar spine BMD and nominally associated with osteoporotic fracture. cis-eQTL analyses of these 2 SNPs, together with SNP rs4727338 (GWAS lead SNP in Estrada et al., Nat Genet.
|
30878523 |
2019 |
|
rs11898505
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Genetic (rs11898505) and non-genetic factors (age, number of falls in a year and L1-4 BMD) could work in concert to contribute to the risk of osteoporotic fractures.
|
22798246 |
2013 |
|
rs784288
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a combined meta-analysis of a discovery cohort (288 cases and 1139 controls), three hospital based sets in replication stage I (462 cases and 1745 controls), and an independent ethnic group in replication stage II (369 cases and 560 for controls), we identified a new locus associated with OF (rs784288 in the MECOM gene) that showed genome-wide significance (p=3.59×10(-8); OR 1.39).
|
23349225 |
2013 |
|
rs1217691063
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, the C677T polymorphism of the MTHFR gene does not appear to be associated with the overall risk of osteoporotic fractures.
|
17712717 |
2007 |
|
rs1217691063
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, we have demonstrated that the rare TT genotype of the C677T polymorphism in the MTHFR gene is associated with increased risk of osteoporotic fractures in women and a weak predictor of lumbar spine BMD.
|
15300362 |
2005 |
|
rs7570532
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the DOPS, individuals homozygous for the variant allele of the MSTN SNP rs7570532 had an increased risk of any osteoporotic fracture, with an HR of 1.82 (95 % CI 1.15-2.90, p = 0.01), and of nonvertebral osteoporotic fracture, with an HR of 2.02 (95 % CI 1.20-3.41, p = 0.01).
|
23370486 |
2013 |
|
rs1217691063
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In the subgroup analysis by ethnicity, the results also showed no significant association between MTHFR C677T poly</span>morphism and susceptibility to osteoporotic fracture in postmenopausal women in both Caucasian and Asian populations.
|
25222234 |
2014 |
|
rs270611
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study provides supportive evidence for the contribution of <i>PDLIM4</i> gene polymorphisms to the susceptibility to osteoporotic fracture and suggests that rs270611 and rs3900945 are genetic risk factors, while rs366512 might be a genetic protective factor against osteoporotic fracture in elderly Han individuals.
|
30578378 |
2019 |
|
rs3900945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study provides supportive evidence for the contribution of <i>PDLIM4</i> gene polymorphisms to the susceptibility to osteoporotic fracture and suggests that rs270611 and rs3900945 are genetic risk factors, while rs366512 might be a genetic protective factor against osteoporotic fracture in elderly Han individuals.
|
30578378 |
2019 |
|
rs366512
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study provides supportive evidence for the contribution of <i>PDLIM4</i> gene polymorphisms to the susceptibility to osteoporotic fracture and suggests that rs270611 and rs3900945 are genetic risk factors, while rs366512 might be a genetic protective factor against osteoporotic fracture in elderly Han individuals.
|
30578378 |
2019 |
|
rs1800012
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Over the past two decades, a low frequency variant (rs1800012) within the first intron of the type I collagen alpha 1 (COLIA1) gene has been implicated in lower areal BMD (aBMD) and increased risk of osteoporotic fracture.
|
30711642 |
2019 |
|
rs11898505
|
|
|
0.020 |
GeneticVariation |
BEFREE |
SPTBN1 (rs11898505) and SOST (rs1107748) were associated with osteoporotic fracture.
|
20554715 |
2010 |
|
rs3917
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The findings showed rs3917 polymorphism interfered with the interaction between COL1A2 mRNA and miR-382, and minor allele is associated with a reduced risk of osteoporotic fracture.
|
30825231 |
2019 |