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rs1800544
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study aimed to investigate the association of rs1800544 polymorphism of α2A-AR gene with BMD and BTMs in the Chinese elderly population with osteoporosis (OP) or with osteoporotic fractures.
|
30033441 |
2018 |
|
rs13182402
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that a SNP, rs13182402 within the ALDH7A1 gene on chromosome 5q31, was strongly associated with OF with evidence combined GWAS and replication studies (P = 2.08x10(-9), odds ratio = 2.25).
|
20072603 |
2010 |
|
rs281865264
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the associations between the Glu298Asp polymorphism of NOS3, indices of bone strength, and the incidence of fracture among 6691 women aged 65 years and older enrolled in the Study of Osteoporotic Fractures.
|
16503213 |
2006 |
|
rs3087456
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Despite increasing bone loss, the rs3087456(G) allele was protective against incident fracture overall (p = 0.002), osteoporotic fracture and hip fracture.
|
23133532 |
2012 |
|
rs1800012
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Over the past two decades, a low frequency variant (rs1800012) within the first intron of the type I collagen alpha 1 (COLIA1) gene has been implicated in lower areal BMD (aBMD) and increased risk of osteoporotic fracture.
|
30711642 |
2019 |
|
rs3917
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The findings showed rs3917 polymorphism interfered with the interaction between COL1A2 mRNA and miR-382, and minor allele is associated with a reduced risk of osteoporotic fracture.
|
30825231 |
2019 |
|
rs758488397
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both variants associate with low BMD and with osteoporotic fractures. p.Gly496Ala (frequency of 0.105%) shows the strongest association with low BMD at the spine (p = 1.8 × 10(-7) , odds ratio [OR] = 4.61 [95% confidence interval (CI) 2.59, 8.18]), whereas p.Gly703Ser (frequency of 0.050%) is most strongly associated with low BMD at the hip (p = 1.9 × 10(-8) , OR = 9.34 [95% CI 4.28, 20.3]).
|
26235824 |
2016 |
|
rs6469804
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A significant gene-gene interaction for osteoporotic fracture involving rs1107748 in SOST and rs6469804 in OPG gene was identified from generalized multifactor dimensionality reduction analysis.
|
20554715 |
2010 |
|
rs6469804
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Among the nine SNPs genotyped, rs6469804 and rs2073618 showed significant associations with both BMD and osteoporotic fractures, while rs3102735 was only associated with BMD in our samples (P < 0.05).
|
28496203 |
2017 |
|
rs4680
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Catechol-O-methyltransferase (COMT) Val158Met polymorphism and risk of osteoporotic fracture.
|
21691708 |
2012 |
|
rs1213308971
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the associations between the Glu298Asp polymorphism of NOS3, indices of bone strength, and the incidence of fracture among 6691 women aged 65 years and older enrolled in the Study of Osteoporotic Fractures.
|
16503213 |
2006 |
|
rs1427938321
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the associations between the Glu298Asp polymorphism of NOS3, indices of bone strength, and the incidence of fracture among 6691 women aged 65 years and older enrolled in the Study of Osteoporotic Fractures.
|
16503213 |
2006 |
|
rs876657777
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the associations between the Glu298Asp polymorphism of NOS3, indices of bone strength, and the incidence of fracture among 6691 women aged 65 years and older enrolled in the Study of Osteoporotic Fractures.
|
16503213 |
2006 |
|
rs1643821
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified one SNP in TNFRSF11B (rs3102734), three SNPs in ESR1 (rs9397448, rs2234693, and rs1643821), two SNPs in LRP4 (rs17790156 and rs898604), and four SNPs in SPTBN1 (rs2971886, rs2941583, rs2941584, and rs12475342) were associated with all of the broadly defined osteoporotic fractures.
|
22807154 |
2012 |
|
rs2234693
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified one SNP in TNFRSF11B (rs3102734), three SNPs in ESR1 (rs9397448, rs2234693, and rs1643821), two SNPs in LRP4 (rs17790156 and rs898604), and four SNPs in SPTBN1 (rs2971886, rs2941583, rs2941584, and rs12475342) were associated with all of the broadly defined osteoporotic fractures.
|
22807154 |
2012 |
|
rs6831280
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>IDUA</i> rs6831280 is associated with BMDs at L2-4 and TH in the elderly Chinese population with SOP and may serve as a marker for the genetic susceptibility to osteoporotic fractures.
|
31275456 |
2019 |
|
rs587777005
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Through whole-genome sequencing of Icelandic individuals, we found a rare nonsense mutation within the leucine-rich-repeat-containing G-protein-coupled receptor 4 (LGR4) gene (c.376C>T) that is strongly associated with low BMD, and with osteoporotic fractures.
|
23644456 |
2013 |
|
rs1107748
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant gene-gene interaction for osteoporotic fracture involving rs1107748 i</span>n SOST and rs6469804 in OPG gene was identified from generalized multifactor dimensionality reduction analysis.
|
20554715 |
2010 |
|
rs17790156
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified one SNP in TNFRSF11B (rs3102734), three SNPs in ESR1 (rs9397448, rs2234693, and rs1643821), two SNPs in LRP4 (rs17790156 and rs898604), and four SNPs in SPTBN1 (rs2971886, rs2941583, rs2941584, and rs12475342) were associated with all of the broadly defined osteoporotic fractures.
|
22807154 |
2012 |
|
rs898604
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified one SNP in TNFRSF11B (rs3102734), three SNPs in ESR1 (rs9397448, rs2234693, and rs1643821), two SNPs in LRP4 (rs17790156 and rs898604), and four SNPs in SPTBN1 (rs2971886, rs2941583, rs2941584, and rs12475342) were associated with all of the broadly defined osteoporotic fractures.
|
22807154 |
2012 |
|
rs3736228
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A non-synonymous SNP in the LRP5 gene was associated with decreased bone mineral density (rs3736228, p=6.3x10(-12) for lumbar spine and p=1.9x10(-4) for femoral neck) and an increased risk of both osteoporotic fractures (odds ratio [OR] 1.3, 95% CI 1.09-1.52, p=0.002) and osteoporosis (OR 1.3, 1.08-1.63, p=0.008).
|
18455228 |
2008 |
|
rs784288
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a combined meta-analysis of a discovery cohort (288 cases and 1139 controls), three hospital based sets in replication stage I (462 cases and 1745 controls), and an independent ethnic group in replication stage II (369 cases and 560 for controls), we identified a new locus associated with OF (rs784288 in the MECOM gene) that showed genome-wide significance (p=3.59×10(-8); OR 1.39).
|
23349225 |
2013 |
|
rs7570532
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the DOPS, individuals homozygous for the variant allele of the MSTN SNP rs7570532 had an increased risk of any osteoporotic fracture, with an HR of 1.82 (95 % CI 1.15-2.90, p = 0.01), and of nonvertebral osteoporotic fracture, with an HR of 2.02 (95 % CI 1.20-3.41, p = 0.01).
|
23370486 |
2013 |
|
rs1217691063
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, we have demonstrated that the rare TT genotype of the C677T polymorphism in the MTHFR gene is associated with increased risk of osteoporotic fractures in women and a weak predictor of lumbar spine BMD.
|
15300362 |
2005 |
|
rs1217691063
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, the C677T polymorphism of the MTHFR gene does not appear to be associated with the overall risk of osteoporotic fractures.
|
17712717 |
2007 |