|
rs10085588
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Eight selected variants were tested for association in the complete cohort and 2 of them (rs4342521 and rs10085588) were found significantly associated with lumbar spine BMD and nominally associated with osteoporotic fracture. cis-eQTL analyses of these 2 SNPs, together with SNP rs4727338 (GWAS lead SNP in Estrada et al., Nat Genet.
|
30878523 |
2019 |
|
rs1800012
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Over the past two decades, a low frequency variant (rs1800012) within the first intron of the type I collagen alpha 1 (COLIA1) gene has been implicated in lower areal BMD (aBMD) and increased risk of osteoporotic fracture.
|
30711642 |
2019 |
|
rs270611
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study provides supportive evidence for the contribution of <i>PDLIM4</i> gene polymorphisms to the susceptibility to osteoporotic fracture and suggests that rs270611 and rs3900945 are genetic risk factors, while rs366512 might be a genetic protective factor against osteoporotic fracture in elderly Han individuals.
|
30578378 |
2019 |
|
rs2908004
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The main finding was that of significant differences in the polymorphisms of the WNT16 rs2908004 genetic variant, notably, the less frequent presence of TC allele in women with a greater risk of osteoporotic fractures.
|
31309515 |
2019 |
|
rs366512
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study provides supportive evidence for the contribution of <i>PDLIM4</i> gene polymorphisms to the susceptibility to osteoporotic fracture and suggests that rs270611 and rs3900945 are genetic risk factors, while rs366512 might be a genetic protective factor against osteoporotic fracture in elderly Han individuals.
|
30578378 |
2019 |
|
rs3900945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study provides supportive evidence for the contribution of <i>PDLIM4</i> gene polymorphisms to the susceptibility to osteoporotic fracture and suggests that rs270611 and rs3900945 are genetic risk factors, while rs366512 might be a genetic protective factor against osteoporotic fracture in elderly Han individuals.
|
30578378 |
2019 |
|
rs3917
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The findings showed rs3917 polymorphism interfered with the interaction between COL1A2 mRNA and miR-382, and minor allele is associated with a reduced risk of osteoporotic fracture.
|
30825231 |
2019 |
|
rs4342521
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Eight selected variants were tested for association in the complete cohort and 2 of them (rs4342521 and rs10085588) were found significantly associated with lumbar spine BMD and nominally associated with osteoporotic fracture. cis-eQTL analyses of these 2 SNPs, together with SNP rs4727338 (GWAS lead SNP in Estrada et al., Nat Genet.
|
30878523 |
2019 |
|
rs6831280
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>IDUA</i> rs6831280 is associated with BMDs at L2-4 and TH in the elderly Chinese population with SOP and may serve as a marker for the genetic susceptibility to osteoporotic fractures.
|
31275456 |
2019 |
|
rs1800544
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study aimed to investigate the association of rs1800544 polymorphism of α2A-AR gene with BMD and BTMs in the Chinese elderly population with osteoporosis (OP) or with osteoporotic fractures.
|
30033441 |
2018 |
|
rs3102735
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the nine SNPs genotyped, rs6469804 and rs2073618 showed significant associations with both BMD and osteoporotic fractures, while rs3102735 was only associated with BMD in our samples (P < 0.05).
|
28496203 |
2017 |
|
rs1982073
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Disease-stratified results yielded that rs1982073 C>T may increase the risk of fracture, OP, and OA under the allele model, but was only significantly related to OP under the dominant model.
|
25501632 |
2016 |
|
rs758488397
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both variants associate with low BMD and with osteoporotic fractures. p.Gly496Ala (frequency of 0.105%) shows the strongest association with low BMD at the spine (p = 1.8 × 10(-7) , odds ratio [OR] = 4.61 [95% confidence interval (CI) 2.59, 8.18]), whereas p.Gly703Ser (frequency of 0.050%) is most strongly associated with low BMD at the hip (p = 1.9 × 10(-8) , OR = 9.34 [95% CI 4.28, 20.3]).
|
26235824 |
2016 |
|
rs3134069
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified the T245G (rs3134069) polymorphism in the TNFRSF11B gene associated with osteoporotic fractures (vertebral fractures: p = 0.0320; non-vertebral fractures: p = 0.0005; all fractures: 0.0000).
|
25323794 |
2015 |
|
rs4986791
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To examine the frequency of TLR4 C1196T genotypes in postmenopausal osteoporotic and non-osteoporotic Polish women and to investigate the possible relationship between C1196T polymorphism, bone mineral density (BMD) and the incidence of osteoporotic fractures in this group of patients.
|
25931355 |
2015 |
|
rs587777005
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Through whole-genome sequencing of Icelandic individuals, we found a rare nonsense mutation within the leucine-rich-repeat-containing G-protein-coupled receptor 4 (LGR4) gene (c.376C>T) that is strongly associated with low BMD, and with osteoporotic fractures.
|
23644456 |
2013 |
|
rs7570532
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the DOPS, individuals homozygous for the variant allele of the MSTN SNP rs7570532 had an increased risk of any osteoporotic fracture, with an HR of 1.82 (95 % CI 1.15-2.90, p = 0.01), and of nonvertebral osteoporotic fracture, with an HR of 2.02 (95 % CI 1.20-3.41, p = 0.01).
|
23370486 |
2013 |
|
rs784288
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In a combined meta-analysis of a discovery cohort (288 cases and 1139 controls), three hospital based sets in replication stage I (462 cases and 1745 controls), and an independent ethnic group in replication stage II (369 cases and 560 for controls), we identified a new locus associated with OF (rs784288 in the MECOM gene) that showed genome-wide significance (p=3.59×10(-8); OR 1.39).
|
23349225 |
2013 |
|
rs12475342
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified one SNP in TNFRSF11B (rs3102734), three SNPs in ESR1 (rs9397448, rs2234693, and rs1643821), two SNPs in LRP4 (rs17790156 and rs898604), and four SNPs in SPTBN1 (rs2971886, rs2941583, rs2941584, and rs12475342) were associated with all of the broadly defined osteoporotic fractures.
|
22807154 |
2012 |
|
rs1643821
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified one SNP in TNFRSF11B (rs3102734), three SNPs in ESR1 (rs9397448, rs2234693, and rs1643821), two SNPs in LRP4 (rs17790156 and rs898604), and four SNPs in SPTBN1 (rs2971886, rs2941583, rs2941584, and rs12475342) were associated with all of the broadly defined osteoporotic fractures.
|
22807154 |
2012 |
|
rs17790156
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified one SNP in TNFRSF11B (rs3102734), three SNPs in ESR1 (rs9397448, rs2234693, and rs1643821), two SNPs in LRP4 (rs17790156 and rs898604), and four SNPs in SPTBN1 (rs2971886, rs2941583, rs2941584, and rs12475342) were associated with all of the broadly defined osteoporotic fractures.
|
22807154 |
2012 |
|
rs2234693
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified one SNP in TNFRSF11B (rs3102734), three SNPs in ESR1 (rs9397448, rs2234693, and rs1643821), two SNPs in LRP4 (rs17790156 and rs898604), and four SNPs in SPTBN1 (rs2971886, rs2941583, rs2941584, and rs12475342) were associated with all of the broadly defined osteoporotic fractures.
|
22807154 |
2012 |
|
rs2941584
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified one SNP in TNFRSF11B (rs3102734), three SNPs in ESR1 (rs9397448, rs2234693, and rs1643821), two SNPs in LRP4 (rs17790156 and rs898604), and four SNPs in SPTBN1 (rs2971886, rs2941583, rs2941584, and rs12475342) were associated with all of the broadly defined osteoporotic fractures.
|
22807154 |
2012 |
|
rs3087456
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Despite increasing bone loss, the rs3087456(G) allele was protective against incident fracture overall (p = 0.002), osteoporotic fracture and hip fracture.
|
23133532 |
2012 |
|
rs3102734
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The most significant polymorphism was rs3102734, with increased risk of osteoporotic fractures (odds ratio, 1.35; 95% confidence interval [CI], 1.17-1.55, Bonferroni p = 2.6 × 10(-4) ).
|
22807154 |
2012 |