|
rs10085588
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Eight selected variants were tested for association in the complete cohort and 2 of them (rs4342521 and rs10085588) were found significantly associated with lumbar spine BMD and nominally associated with osteoporotic fracture. cis-eQTL analyses of these 2 SNPs, together with SNP rs4727338 (GWAS lead SNP in Estrada et al., Nat Genet.
|
30878523 |
2019 |
|
rs1107748
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A significant gene-gene interaction for osteoporotic fracture involving rs1107748 i</span>n SOST and rs6469804 in OPG gene was identified from generalized multifactor dimensionality reduction analysis.
|
20554715 |
2010 |
|
rs11898505
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Genetic (rs11898505) and non-genetic factors (age, number of falls in a year and L1-4 BMD) could work in concert to contribute to the risk of osteoporotic fractures.
|
22798246 |
2013 |
|
rs11898505
|
|
|
0.020 |
GeneticVariation |
BEFREE |
SPTBN1 (rs11898505) and SOST (rs1107748) were associated with osteoporotic fracture.
|
20554715 |
2010 |
|
rs1213308971
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the associations between the Glu298Asp polymorphism of NOS3, indices of bone strength, and the incidence of fracture among 6691 women aged 65 years and older enrolled in the Study of Osteoporotic Fractures.
|
16503213 |
2006 |
|
rs1217691063
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, we have demonstrated that the rare TT genotype of the C677T polymorphism in the MTHFR gene is associated with increased risk of osteoporotic fractures in women and a weak predictor of lumbar spine BMD.
|
15300362 |
2005 |
|
rs1217691063
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, the C677T polymorphism of the MTHFR gene does not appear to be associated with the overall risk of osteoporotic fractures.
|
17712717 |
2007 |
|
rs1217691063
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In the subgroup analysis by ethnicity, the results also showed no significant association between MTHFR C677T poly</span>morphism and susceptibility to osteoporotic fracture in postmenopausal women in both Caucasian and Asian populations.
|
25222234 |
2014 |
|
rs12475342
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified one SNP in TNFRSF11B (rs3102734), three SNPs in ESR1 (rs9397448, rs2234693, and rs1643821), two SNPs in LRP4 (rs17790156 and rs898604), and four SNPs in SPTBN1 (rs2971886, rs2941583, rs2941584, and rs12475342) were associated with all of the broadly defined osteoporotic fractures.
|
22807154 |
2012 |
|
rs13182402
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found that a SNP, rs13182402 within the ALDH7A1 gene on chromosome 5q31, was strongly associated with OF with evidence combined GWAS and replication studies (P = 2.08x10(-9), odds ratio = 2.25).
|
20072603 |
2010 |
|
rs1427938321
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the associations between the Glu298Asp polymorphism of NOS3, indices of bone strength, and the incidence of fracture among 6691 women aged 65 years and older enrolled in the Study of Osteoporotic Fractures.
|
16503213 |
2006 |
|
rs1643821
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified one SNP in TNFRSF11B (rs3102734), three SNPs in ESR1 (rs9397448, rs2234693, and rs1643821), two SNPs in LRP4 (rs17790156 and rs898604), and four SNPs in SPTBN1 (rs2971886, rs2941583, rs2941584, and rs12475342) were associated with all of the broadly defined osteoporotic fractures.
|
22807154 |
2012 |
|
rs17790156
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified one SNP in TNFRSF11B (rs3102734), three SNPs in ESR1 (rs9397448, rs2234693, and rs1643821), two SNPs in LRP4 (rs17790156 and rs898604), and four SNPs in SPTBN1 (rs2971886, rs2941583, rs2941584, and rs12475342) were associated with all of the broadly defined osteoporotic fractures.
|
22807154 |
2012 |
|
rs1799983
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the associations between the Glu298Asp polymorphism of NOS3, indices of bone strength, and the incidence of fracture among 6691 women aged 65 years and older enrolled in the Study of Osteoporotic Fractures.
|
16503213 |
2006 |
|
rs1800012
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Over the past two decades, a low frequency variant (rs1800012) within the first intron of the type I collagen alpha 1 (COLIA1) gene has been implicated in lower areal BMD (aBMD) and increased risk of osteoporotic fracture.
|
30711642 |
2019 |
|
rs1800544
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study aimed to investigate the association of rs1800544 polymorphism of α2A-AR gene with BMD and BTMs in the Chinese elderly population with osteoporosis (OP) or with osteoporotic fractures.
|
30033441 |
2018 |
|
rs1800629
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We evaluated the association between a G-308A polymorphism (rs1800629) at the TNFA locus and osteoporosis phenotypes in 4306 older women participating in the Study of Osteoporotic Fractures.
|
15797957 |
2005 |
|
rs1982073
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Disease-stratified results yielded that rs1982073 C>T may increase the risk of fracture, OP, and OA under the allele model, but was only significantly related to OP under the dominant model.
|
25501632 |
2016 |
|
rs2073618
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Among the nine SNPs genotyped, rs6469804 and rs2073618 showed significant associations with both BMD and osteoporotic fractures, while rs3102735 was only associated with BMD in our samples (P < 0.05).
|
28496203 |
2017 |
|
rs2073618
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We investigated the association between a Lys3Asn polymorphism in the OPG gene and bone mineral density (BMD), and the risk of fracture in 6695 women aged 65 yr and older participating in the Study of Osteoporotic Fractures.
|
18319311 |
2008 |
|
rs2234693
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified one SNP in TNFRSF11B (rs3102734), three SNPs in ESR1 (rs9397448, rs2234693, and rs1643821), two SNPs in LRP4 (rs17790156 and rs898604), and four SNPs in SPTBN1 (rs2971886, rs2941583, rs2941584, and rs12475342) were associated with all of the broadly defined osteoporotic fractures.
|
22807154 |
2012 |
|
rs270611
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study provides supportive evidence for the contribution of <i>PDLIM4</i> gene polymorphisms to the susceptibility to osteoporotic fracture and suggests that rs270611 and rs3900945 are genetic risk factors, while rs366512 might be a genetic protective factor against osteoporotic fracture in elderly Han individuals.
|
30578378 |
2019 |
|
rs281865264
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We examined the associations between the Glu298Asp polymorphism of NOS3, indices of bone strength, and the incidence of fracture among 6691 women aged 65 years and older enrolled in the Study of Osteoporotic Fractures.
|
16503213 |
2006 |
|
rs2908004
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The main finding was that of significant differences in the polymorphisms of the WNT16 rs2908004 genetic variant, notably, the less frequent presence of TC allele in women with a greater risk of osteoporotic fractures.
|
31309515 |
2019 |
|
rs2941584
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified one SNP in TNFRSF11B (rs3102734), three SNPs in ESR1 (rs9397448, rs2234693, and rs1643821), two SNPs in LRP4 (rs17790156 and rs898604), and four SNPs in SPTBN1 (rs2971886, rs2941583, rs2941584, and rs12475342) were associated with all of the broadly defined osteoporotic fractures.
|
22807154 |
2012 |