|
rs1217691063
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In the subgroup analysis by ethnicity, the results also showed no significant association between MTHFR C677T poly</span>morphism and susceptibility to osteoporotic fracture in postmenopausal women in both Caucasian and Asian populations.
|
25222234 |
2014 |
|
rs1217691063
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, the C677T polymorphism of the MTHFR gene does not appear to be associated with the overall risk of osteoporotic fractures.
|
17712717 |
2007 |
|
rs1217691063
|
|
|
0.030 |
GeneticVariation |
BEFREE |
In conclusion, we have demonstrated that the rare TT genotype of the C677T polymorphism in the MTHFR gene is associated with increased risk of osteoporotic fractures in women and a weak predictor of lumbar spine BMD.
|
15300362 |
2005 |
|
rs2073618
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Among the nine SNPs genotyped, rs6469804 and rs2073618 showed significant associations with both BMD and osteoporotic fractures, while rs3102735 was only associated with BMD in our samples (P < 0.05).
|
28496203 |
2017 |
|
rs6469804
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Among the nine SNPs genotyped, rs6469804 and rs2073618 showed significant associations with both BMD and osteoporotic fractures, while rs3102735 was only associated with BMD in our samples (P < 0.05).
|
28496203 |
2017 |
|
rs11898505
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Genetic (rs11898505) and non-genetic factors (age, number of falls in a year and L1-4 BMD) could work in concert to contribute to the risk of osteoporotic fractures.
|
22798246 |
2013 |
|
rs11898505
|
|
|
0.020 |
GeneticVariation |
BEFREE |
SPTBN1 (rs11898505) and SOST (rs1107748) were associated with osteoporotic fracture.
|
20554715 |
2010 |
|
rs6469804
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A significant gene-gene interaction for osteoporotic fracture involving rs1107748 in SOST and rs6469804 in OPG gene was identified from generalized multifactor dimensionality reduction analysis.
|
20554715 |
2010 |
|
rs2073618
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We investigated the association between a Lys3Asn polymorphism in the OPG gene and bone mineral density (BMD), and the risk of fracture in 6695 women aged 65 yr and older participating in the Study of Osteoporotic Fractures.
|
18319311 |
2008 |
|
rs10085588
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Eight selected variants were tested for association in the complete cohort and 2 of them (rs4342521 and rs10085588) were found significantly associated with lumbar spine BMD and nominally associated with osteoporotic fracture. cis-eQTL analyses of these 2 SNPs, together with SNP rs4727338 (GWAS lead SNP in Estrada et al., Nat Genet.
|
30878523 |
2019 |
|
rs1800012
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Over the past two decades, a low frequency variant (rs1800012) within the first intron of the type I collagen alpha 1 (COLIA1) gene has been implicated in lower areal BMD (aBMD) and increased risk of osteoporotic fracture.
|
30711642 |
2019 |
|
rs270611
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study provides supportive evidence for the contribution of <i>PDLIM4</i> gene polymorphisms to the susceptibility to osteoporotic fracture and suggests that rs270611 and rs3900945 are genetic risk factors, while rs366512 might be a genetic protective factor against osteoporotic fracture in elderly Han individuals.
|
30578378 |
2019 |
|
rs2908004
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The main finding was that of significant differences in the polymorphisms of the WNT16 rs2908004 genetic variant, notably, the less frequent presence of TC allele in women with a greater risk of osteoporotic fractures.
|
31309515 |
2019 |
|
rs366512
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study provides supportive evidence for the contribution of <i>PDLIM4</i> gene polymorphisms to the susceptibility to osteoporotic fracture and suggests that rs270611 and rs3900945 are genetic risk factors, while rs366512 might be a genetic protective factor against osteoporotic fracture in elderly Han individuals.
|
30578378 |
2019 |
|
rs3900945
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study provides supportive evidence for the contribution of <i>PDLIM4</i> gene polymorphisms to the susceptibility to osteoporotic fracture and suggests that rs270611 and rs3900945 are genetic risk factors, while rs366512 might be a genetic protective factor against osteoporotic fracture in elderly Han individuals.
|
30578378 |
2019 |
|
rs3917
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The findings showed rs3917 polymorphism interfered with the interaction between COL1A2 mRNA and miR-382, and minor allele is associated with a reduced risk of osteoporotic fracture.
|
30825231 |
2019 |
|
rs4342521
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Eight selected variants were tested for association in the complete cohort and 2 of them (rs4342521 and rs10085588) were found significantly associated with lumbar spine BMD and nominally associated with osteoporotic fracture. cis-eQTL analyses of these 2 SNPs, together with SNP rs4727338 (GWAS lead SNP in Estrada et al., Nat Genet.
|
30878523 |
2019 |
|
rs6831280
|
|
|
0.010 |
GeneticVariation |
BEFREE |
<i>IDUA</i> rs6831280 is associated with BMDs at L2-4 and TH in the elderly Chinese population with SOP and may serve as a marker for the genetic susceptibility to osteoporotic fractures.
|
31275456 |
2019 |
|
rs1800544
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The present study aimed to investigate the association of rs1800544 polymorphism of α2A-AR gene with BMD and BTMs in the Chinese elderly population with osteoporosis (OP) or with osteoporotic fractures.
|
30033441 |
2018 |
|
rs3102735
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Among the nine SNPs genotyped, rs6469804 and rs2073618 showed significant associations with both BMD and osteoporotic fractures, while rs3102735 was only associated with BMD in our samples (P < 0.05).
|
28496203 |
2017 |
|
rs1982073
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Disease-stratified results yielded that rs1982073 C>T may increase the risk of fracture, OP, and OA under the allele model, but was only significantly related to OP under the dominant model.
|
25501632 |
2016 |
|
rs758488397
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Both variants associate with low BMD and with osteoporotic fractures. p.Gly496Ala (frequency of 0.105%) shows the strongest association with low BMD at the spine (p = 1.8 × 10(-7) , odds ratio [OR] = 4.61 [95% confidence interval (CI) 2.59, 8.18]), whereas p.Gly703Ser (frequency of 0.050%) is most strongly associated with low BMD at the hip (p = 1.9 × 10(-8) , OR = 9.34 [95% CI 4.28, 20.3]).
|
26235824 |
2016 |
|
rs3134069
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We identified the T245G (rs3134069) polymorphism in the TNFRSF11B gene associated with osteoporotic fractures (vertebral fractures: p = 0.0320; non-vertebral fractures: p = 0.0005; all fractures: 0.0000).
|
25323794 |
2015 |
|
rs4986791
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To examine the frequency of TLR4 C1196T genotypes in postmenopausal osteoporotic and non-osteoporotic Polish women and to investigate the possible relationship between C1196T polymorphism, bone mineral density (BMD) and the incidence of osteoporotic fractures in this group of patients.
|
25931355 |
2015 |
|
rs587777005
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Through whole-genome sequencing of Icelandic individuals, we found a rare nonsense mutation within the leucine-rich-repeat-containing G-protein-coupled receptor 4 (LGR4) gene (c.376C>T) that is strongly associated with low BMD, and with osteoporotic fractures.
|
23644456 |
2013 |