|
Prostate cancer, familial
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A recurrent mutation in HOXB13 has been shown to predispose to hereditary prostate cancer (HPC), and BRCA2 mutations to hereditary breast and ovarian cancer (HBOC).
|
27899188 |
2016 |
|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
For example, a recent study suggested that one cannot adequately impute the HOXB13 G84E mutation associated with prostate cancer risk (carrier frequency of 0.0034 in European ancestry participants in the 1000 Genomes Project).
|
25629170 |
2015 |
|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The HOXB13 G84E Mutation Is Associated with an Increased Risk for Prostate Cancer and Other Malignancies.
|
26108461 |
2015 |
|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
UNIPROT |
For example, a recent study suggested that one cannot adequately impute the HOXB13 G84E mutation associated with prostate cancer risk (carrier frequency of 0.0034 in European ancestry participants in the 1000 Genomes Project).
|
25629170 |
2015 |
|
Malignant neoplasm of prostate
|
0.600 |
Biomarker
|
disease |
CTD_human |
The androgen receptor cistrome is extensively reprogrammed in human prostate tumorigenesis.
|
26457646 |
2015 |
|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Then, 25 studies including 51,390 cases and 93,867 controls were included, and there was significant association between HOXB13 p.Gly84Glu mutation and overall cancer risk (OR = 2.872, 95% CI = 2.121-3.888, P < 0.001), particularly in prostate cancer (OR = 3.248, 95% CI = 2.313-4.560, P < 0.001), while no association was found in breast (OR = 1.424, 95% CI = 0.776-2.613, P = 0.253) and colorectal cancers (OR = 2.070, 95% CI = 0.485-8.841, P = 0.326).
|
26517352 |
2015 |
|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We found that the polygenic PrCa risk score (PR score), calculated using the 71 known single-nucleotide polymorphisms (SNPs) associated with PrCa and the HOXB13 G84E variant act multiplicatively on PrCa risk.
|
25595936 |
2015 |
|
Prostate cancer, familial
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A rare recurrent missense variant in HOXB13 (rs138213197/rs138213197" genes_norm="10481">G84E) was recently reported to be associated with hereditary prostate cancer.
|
25595936 |
2015 |
|
Malignant neoplasm of prostate
|
0.600 |
Biomarker
|
disease |
CTD_human |
Human HOX gene disorders.
|
24239177 |
2014 |
|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
HOXB13 G84E-related familial prostate cancers: a clinical, histologic, and molecular survey.
|
24722062 |
2014 |
|
Malignant neoplasm of prostate
|
0.600 |
Biomarker
|
disease |
BEFREE |
HOXB13, RFX6 and prostate cancer risk.
|
24473320 |
2014 |
|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Additional genotyping, conditional regression and haplotype analyses indicated that the newly identified common variants tag a rare, partially correlated coding variant in the HOXB13 gene (rs138213197" genes_norm="10481">G84E, rs138213197), which has been identified recently as a moderate penetrance PrCa susceptibility allele.
|
24550738 |
2014 |
|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
HOXB13 G84E was observed in 1.3% of population controls and was strongly associated with prostate cancer risk (CAPS: odds ratio [OR]: 3.4; 95% confidence interval [CI], 2.2-5.4; Stockholm-1: OR: 3.5; 95% CI, 2.4-5.2).
|
22841674 |
2014 |
|
Malignant neoplasm of prostate
|
0.600 |
Biomarker
|
disease |
CTD_human |
Together, our results suggest that rs339331 affects prostate cancer risk by altering RFX6 expression through a functional interaction with the prostate cancer susceptibility gene HOXB13.
|
24390282 |
2014 |
|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
While the HOXB13 G84E mutation may be rare, there may be a future role in genetic testing for this mutation after further studies of clinical utility in assessing prostate cancer risk.
|
24310616 |
2014 |
|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
G84E mutation in HOXB13 is firmly associated with prostate cancer risk: a meta-analysis.
|
24026887 |
2014 |
|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Together, our results suggest that rs339331 affects prostate cancer risk by altering RFX6 expression through a functional interaction with the prostate cancer susceptibility gene HOXB13.
|
24390282 |
2014 |
|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In the present study, carriers of the rare G84E variant in HOXB13 were both younger at the time of diagnosis and more likely to have a family history of prostate cancer compared with homozygotes for the wild-type allele.
|
24148311 |
2014 |
|
Prostate cancer, familial
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Recent genetic epidemiologic studies identified a germline mutation in the homeobox transcription factor, HOXB13 G84E, which is associated with markedly increased risk for prostate cancer, particularly early-onset hereditary prostate cancer.
|
24722062 |
2014 |
|
Prostate cancer, familial
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A rare but recurrent missense mutation (rs138213197" genes_norm="10481">G84E, rs138213197) in the gene homeobox B13 (HOXB13) was recently reported to be associated with hereditary prostate cancer.
|
22841674 |
2014 |
|
Prostate cancer, familial
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Men with the HOXB13 G84E variant had a 4.51-fold higher relative risk of PCa compared with non-carriers (95 % CI 3.28-6.20).
|
24026887 |
2014 |
|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The goal of this study is to test association between HOXB13 genetic variants and PCa risk in Chinese men.
|
22718278 |
2013 |
|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The G84E mutation in the HOXB13 gene is associated with an increased risk of prostate cancer in Poland.
|
23334858 |
2013 |
|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Pedigree analysis of cases and controls revealed that 7/21 HOXB13 mutation carriers had a family history of prostate cancer.
|
23541221 |
2013 |
|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The G84E variant of HOXB13 was recently found to be associated with a significantly increased risk of prostate cancer in a case control study.
|
23036981 |
2013 |