|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Recently, a rare, recurrent mutation (G84E) in HOXB13 was reported to be associated with prostate cancer risk.
|
23064873 |
2013 |
|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the G84E mutation of HOXB13, a relatively recent mutation that likely occurred in Northern Europe, significantly increases risk for PCa.
|
23393222 |
2013 |
|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
UNIPROT |
A recently identified germline mutation G84E in HOXB13 was shown to increase the risk of prostate cancer.
|
23292082 |
2013 |
|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
HOXB13 mutation and prostate cancer: studies of siblings and aggressive disease.
|
23396964 |
2013 |
|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These results confirm the association of a rare HOXB13 mutation with PC in the general population and suggest that this variant may be associated with features of more aggressive disease.
|
23129385 |
2013 |
|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study has also shown that the majority of hereditary prostate cancers due to the HOXB13 missense mutation are 'sporadic' in the sense that unselected cases with the missense mutation do not typically report having a family history of prostate cancer.
|
23457453 |
2013 |
|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study confirms the overall importance of the HOXB13 G84E mutation in prostate cancer susceptibility.
|
23292082 |
2013 |
|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
UNIPROT |
To examine this finding in a large international sample of prostate cancer families, we genotyped this mutation and 14 other SNPs in or flanking HOXB13 in 2,443 prostate cancer families recruited by the International Consortium for Prostate Cancer Genetics (ICPCG).
|
23064873 |
2013 |
|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Prevalence of HOXB13 mutation in a population of Ashkenazi Jewish men treated for prostate cancer.
|
23475555 |
2013 |
|
Prostate cancer, familial
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The HOXB13 mutation substantially increases risk of early onset, familial prostate cancer in European-American men.
|
23396964 |
2013 |
|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Germline mutations in HOXB13 and prostate-cancer risk.
|
22236224 |
2012 |
|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
UNIPROT |
Our study confirmed the association between the G84E mutation of HOXB13 and risk of prostate cancer among subjects of European descent.
|
22714738 |
2012 |
|
Malignant neoplasm of prostate
|
0.600 |
Biomarker
|
disease |
CTD_human |
We also report results for a previously described HOXB13 variant (rs138213197[T]), confirming it as a prostate cancer risk variant in populations from across Europe.
|
23104005 |
2012 |
|
Malignant neoplasm of prostate
|
0.600 |
Biomarker
|
disease |
BEFREE |
Recently, the HOXB13 gene has been shown to be a susceptibility gene for prostate cancer.
|
23099437 |
2012 |
|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We also report results for a previously described HOXB13 variant (rs138213197[T]), confirming it as a prostate cancer risk variant in populations from across Europe.
|
23104005 |
2012 |
|
Malignant neoplasm of prostate
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Results from this study implicated a novel effect of ATRA in inhibition of the growth of AR(-) resistant human prostate cancer cells through alteration of HOXB13 expression as a result of epigenetic modifications.
|
22808286 |
2012 |
|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To confirm this association in a screening setting, we conducted a case-control study and sequenced germline DNA from peripheral leukocytes of 1843 men diagnosed with prostate cancer (case subjects) and 2225 men without prostate cancer (control subjects) for mutations in HOXB13.
|
22781434 |
2012 |
|
Malignant neoplasm of prostate
|
0.600 |
Biomarker
|
disease |
BEFREE |
Rare mutations in genes such as BRCA1, BRCA2 and HOXB13 can affect prostate cancer incidence and/or clinical behaviour.
|
22974436 |
2012 |
|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
UNIPROT |
Germline mutations in HOXB13 and prostate-cancer risk.
|
22236224 |
2012 |
|
Malignant neoplasm of prostate
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our study confirmed the association between the G84E mutation of HOXB13 and risk of prostate cancer among subjects of European descent.
|
22714738 |
2012 |
|
Prostate cancer, familial
|
0.600 |
Biomarker
|
disease |
CTD_human |
The novel HOXB13 G84E variant is associated with a significantly increased risk of hereditary prostate cancer.
|
22236224 |
2012 |
|
Prostate cancer, familial
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The novel HOXB13 G84E variant is associated with a significantly increased risk of hereditary prostate cancer.
|
22236224 |
2012 |
|
Prostate cancer, familial
|
0.600 |
SusceptibilityMutation
|
disease |
ORPHANET |
The novel HOXB13 G84E variant is associated with a significantly increased risk of hereditary prostate cancer.
|
22236224 |
2012 |
|
Prostate cancer, familial
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We evaluated the rs138213197" genes_norm="10481">G84E germline mutation (rs138213197) of HOXB13 in a case-control study of familial prostate cancer at Vanderbilt University (Nashville, TN) to independently evaluate the association of the mutation with familial prostate cancer.
|
22714738 |
2012 |
|
Malignant neoplasm of prostate
|
0.600 |
Biomarker
|
disease |
BEFREE |
However, the role of the HOXB13 in androgen-independent growth of prostate cancer cells remains unexplained.
|
20504375 |
2010 |