|
Atherosclerosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
This review aims to investigate the expression changes of CXCL2 in acute myocardial infarction (AMI), atherosclerosis (AS), obesity, diabetes and ischemic stroke (IS) and its potential key role in cardiovascular disease in order to provide new ideas for the prevention and treatment of cardiovascular diseases.
|
31752549 |
2019 |
|
Atherosclerosis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Here, we further compare the role of <i>P. gingivalis</i> cells and their vesicles in expression of chemoattractant proteins including CXCL1, CXCL2, and CXCL8, and adhesive molecules such as E-selectin in human umbilical vein endothelial cells (HUVECs).Both <i>P. gingivalis</i> 33277 cells and vesicles were able to up-regulate expression of these molecules, while the vesicles acted as more potent inducers of the inflammatory response associated with the development of atherosclerosis, consequently resulting in significant monocyte adhesion to a monolayer of HUVECs.
|
27826542 |
2016 |
|
Auricular swelling
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Camp(-/-) mice lacking cathelicidin demonstrated a large increase in ear swelling, cell infiltration, and MIP-2 expression compared with wild type mice.
|
18768846 |
2008 |
|
Bacterial Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
In conclusion, the multifunctional chemokines CCL3 and CXCL2 are produced locally in response to bacterial infection of bones.
|
24795505 |
2014 |
|
Bacteroides fragilis infection in conditions classified elsewhere and of unspecified site
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We measured the stool abundance of selected bacterial GMB taxa (Escherichia/Shigella, Pseudomonas aeruginosa, Eubacterium rectale, Eubacterium hallii, Faecalibacterium prausnitzii, and Bacteroides fragilis) and the blood expression levels of cytokines (pro-inflammatory cytokines: CXCL2, CXCL10, interleukin [IL]-1β, IL-6, IL-18, IL-8, inflammasome complex (NLRP3), tumor necrosis factor-alpha [TNF-α]; anti-inflammatory cytokines: IL-4, IL-10, IL-13) in cognitively impaired patients with (n = 40, Amy+) and with no brain amyloidosis (n = 33, Amy-) and also in a group of controls (n = 10, no brain amyloidosis and no cognitive impairment).
|
27776263 |
2017 |
|
Bladder Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we identified a mechanism by which tumor cells induce MDSC accumulation and expansion in the bladder cancer (BC) microenvironment via CXCL2/MIF-CXCR2 signaling.
|
27721403 |
2017 |
|
Bone Resorption
|
0.300 |
Therapeutic
|
phenotype |
CTD_human |
CXCL2 mediates lipopolysaccharide-induced osteoclastogenesis in RANKL-primed precursors.
|
21507677 |
2011 |
|
Brain Edema
|
0.200 |
Biomarker
|
phenotype |
RGD |
These results suggest that MIP-2 expression may play an important role in the development of brain edema after ICH in rats.
|
18830379 |
2009 |
|
Breast Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
ERE-independent ERalpha target genes differentially expressed in human breast tumors.
|
16298037 |
2005 |
|
Carcinogenesis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Overall, high GRO-β expression correlates with poor prognosis and contributes to ovarian cancer tumorigenesis and metastasis.
|
26063953 |
2015 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
CRCSC-secreted CXCL1 and CXCL2 then attracted CRCSC-primed neutrophils to promote tumorigenesis of CRC cells via IL-1β.
|
30683126 |
2019 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Therefore, CXCL2-CXCR2 axis mediates through Gαi-2 and Gαq/11 to promote tumorigenesis and contributes to CSC properties of CPT-11-R LoVo cells.
|
30552676 |
2019 |
|
Carcinoma of bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we identified a mechanism by which tumor cells induce MDSC accumulation and expansion in the bladder cancer (BC) microenvironment via CXCL2/MIF-CXCR2 signaling.
|
27721403 |
2017 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Next, we observed the correlation between GRO-β expression and clinicopathological features of ovarian cancer as well as patient outcome.
|
26063953 |
2015 |
|
Cardiovascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
This review aims to investigate the expression changes of CXCL2 in acute myocardial infarction (AMI), atherosclerosis (AS), obesity, diabetes and ischemic stroke (IS) and its potential key role in cardiovascular disease in order to provide new ideas for the prevention and treatment of cardiovascular diseases.
|
31752549 |
2019 |
|
Carney Complex
|
0.010 |
Biomarker
|
disease |
BEFREE |
In DfAf mice, ITCZ and LAMB significantly decreased the elevation of MIP-2 (p < 0.05 vs the DfAf group).
|
31396817 |
2019 |
|
Cerebellar Ataxia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
When IFNγ signaling is impaired, myeloid cell production of CXCL2 increases, which promotes brainstem inflammation and results in clinical ataxia.
|
30012158 |
2018 |
|
Cholangitis
|
0.200 |
Therapeutic
|
disease |
RGD |
Effect of glucocorticoid pretreatment on oxidative liver injury and survival in jaundiced rats with endotoxin cholangitis.
|
17102917 |
2006 |
|
Cholestasis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis.
|
21224055 |
2011 |
|
Chronic Airflow Obstruction
|
0.300 |
Biomarker
|
disease |
CTD_human |
Aberrantly activated EGFR contributes to enhanced IL-8 expression in COPD airways epithelial cells via regulation of nuclear FoxO3A.
|
23099361 |
2013 |
|
Chronic Obstructive Airway Disease
|
0.310 |
Biomarker
|
disease |
BEFREE |
Within this context, we now show increased expression of the C-X-C chemokines (CXCL1 and CXCL2) and their receptor CXCR2, and the intercellular cellular adhesion molecule-1 (ICAM-1), in the lung tissues of patients with COPD.
|
26747783 |
2016 |
|
Chronic Obstructive Airway Disease
|
0.310 |
Biomarker
|
disease |
CTD_human |
Aberrantly activated EGFR contributes to enhanced IL-8 expression in COPD airways epithelial cells via regulation of nuclear FoxO3A.
|
23099361 |
2013 |
|
Colon Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Analysis of human databases from colon cancer and ulcerative colitis patients showed that lipin-1 expression is increased in those disorders and correlates with the expression of the proinflammatory markers CXCL1 and CXCL2.
|
30232275 |
2018 |
|
Colonic Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Addition of MMM to colon tumors <i>in vivo</i> significantly enhances tumor growth in control tumors and restores tumor growth in the presence of MK2 inhibition.
|
30298062 |
2018 |
|
Colonic Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Increased number and size of colon tumors and intestinal epithelial cell proliferation in recolonized germ-free mice were associated with augmented intratumoral CXCL1, CXCL2, and CXCL5 expression and granulocytic myeloid-derived suppressor cell (G-MDSC) accumulation.
|
30782668 |
2019 |