|
Hepatitis C
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
The aim was to estimate the association of TLR8 polymorphisms with HCV-related outcomes in HIV/HCV coinfected patients.
|
26455634 |
2015 |
|
Hepatitis C
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Our previous study demonstrated that the TLR8-129G>C (rs3764879) and TLR8+1G>A (rs3764880) variants were in complete linkage disequilibrium, and that the frequency of TLR8-129C/+1A was significantly higher in male patients with HCV infection compared with the healthy controls.
|
24205871 |
2014 |
|
Hepatitis C
|
0.080 |
Biomarker
|
disease |
BEFREE |
Stimulation of normal monocytes with TLR4 and TLR8 ligands or HCV core, NS3 and NS5 recombinant proteins induced a robust increase in both miR-155 expression and TNFα production identifying potential mechanisms for in vivo induction of miR-155.
|
22846613 |
2012 |
|
Hepatitis C
|
0.080 |
Biomarker
|
disease |
BEFREE |
This suggests that variations in TLR7 and TLR8 genes might impair immune responses during HCV infection.
|
22022576 |
2011 |
|
Autoimmune Diseases
|
0.070 |
Biomarker
|
group |
BEFREE |
Here, we report the implication of TLR7 signaling in high fat diet (HFD)-induced metabolic syndrome and exacerbation of lupus autoimmunity in TLR8-deficient (TLR8ko) mice, which develop spontaneous lupus-like disease due to increased TLR7 signaling by dendritic cells (DCs).
|
31552019 |
2019 |
|
Autoimmune Diseases
|
0.070 |
Biomarker
|
group |
BEFREE |
Given the role of TLR8 in autoimmunity, we also optimized the potency of <b>2</b> and developed a new TLR8 inhibitor bearing a 1,3,4-oxadiazole motif.
|
31687820 |
2019 |
|
Autoimmune Diseases
|
0.070 |
Biomarker
|
group |
BEFREE |
A variety of biological evaluations in cultured cell lines, human peripheral blood mononuclear cells, and splenocytes from human TLR8-transgenic mice further demonstrated these TLR8 inhibitors' high efficacy, suggesting strong therapeutic potential against autoimmune disorders.
|
30100350 |
2018 |
|
Autoimmune Diseases
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Altogether, data uncover novel effects that type I IFN exerts in TLR8-activated neutrophils, which therefore enlarge our knowledge on the various biological actions which type I IFN orchestrates during infectious and autoimmune diseases.
|
26790609 |
2016 |
|
Autoimmune Diseases
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Illness may be caused by constitutive activation of human TLR7 or TLR8 in the bacterial artificial chromosome positive mice as increased TLR7 and TLR8 expression or activation has previously been implicated in autoimmune disease.
|
25229618 |
2014 |
|
Autoimmune Diseases
|
0.070 |
Biomarker
|
group |
BEFREE |
We found that the consequence of self-recognition via TLR8 results in a constellation of diseases, strikingly distinct from those related to TLR7 signaling, and points to specific inflammatory diseases that may benefit from inhibition of TLR8 in humans.
|
24277153 |
2013 |
|
Autoimmune Diseases
|
0.070 |
Biomarker
|
group |
BEFREE |
Both TLR8 and TLR7 are functional candidate genes owing to their key roles as pathogen recognition receptors and, in the case of TLR7, overexpression has been associated directly with murine autoimmune disease.
|
19956107 |
2009 |
|
Neoplasms
|
0.050 |
GeneticVariation
|
group |
BEFREE |
We previously reported that TLR8 expression was increased directly by the tumor suppressor and transcription factor p53 via a single nucleotide polymorphism (SNP) (rs3761624) in the TLR8 promoter, thereby placing TLR8 in the p53/immune axis.
|
31430261 |
2019 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
As the receptor of single stranded RNA (ssRNA), toll-like receptor 8 (TLR8) has potential in the treatment of tumors, microbial infection, and inflammatory diseases.
|
30568763 |
2018 |
|
Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
More importantly, TLR7/TLR8 expression increased tumor growth in vivo.
|
26134824 |
2015 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
It is reported to be a TLR7 and TLR8 agonist and, as such, initiates a Th1 immune response by activating sentinel cells in the vicinity of the tumour.
|
23995793 |
2013 |
|
Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
We explored the status of expression and function of TLR7, TLR8, and TLR9 in primary human Langerhans cells (LCs) isolated from cervical tumors.
|
23221735 |
2013 |
|
Tuberculosis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The A-allele of TLR8 rs3764880 SNP was protective against the development of TB in males (A vs G, OR = 0.58, 95%CI = 0.37-0.91).
|
30424735 |
2018 |
|
Tuberculosis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, these findings provide evidence that TLR7 and TLR8 genetic polymorphisms are associated with susceptibility to MTB infection, and the link is shaped by less effective MTB phagocytosis and impaired TLR signaling.
|
27156628 |
2016 |
|
Tuberculosis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Association of toll-like receptors with susceptibility to tuberculosis suggests sex-specific effects of TLR8 polymorphisms.
|
26160538 |
2015 |
|
Tuberculosis
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We found that four polymorphisms in the TLR8 gene on chromosome X showed evidence of association with TB susceptibility in males, including a non-synonymous polymorphism rs3764880 (Met1Val; P = 0.007, odds ratio (OR) = 1.8, 95% c.i.= 1.2-2.7).
|
18927625 |
2008 |
|
Rheumatoid Arthritis
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Here we showed that a quarter to a third of men with rheumatoid arthritis (RA) had significantly increased copy numbers (CN) of TLR7 gene and its paralog TLR8.
|
31501466 |
2019 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
We conclude that p53 can strongly influence TLR8-mediated immune responses and that knowledge of the p53-responsive SNP can inform diagnosis and prognosis of RSV disease and other diseases that might have a TLR8 component, including cancer.
|
31430261 |
2019 |
|
Lupus Erythematosus
|
0.030 |
Biomarker
|
disease |
BEFREE |
Here, we report the implication of TLR7 signaling in high fat diet (HFD)-induced metabolic syndrome and exacerbation of lupus autoimmunity in TLR8-deficient (TLR8ko) mice, which develop spontaneous lupus-like disease due to increased TLR7 signaling by dendritic cells (DCs).
|
31552019 |
2019 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
We conclude that p53 can strongly influence TLR8-mediated immune responses and that knowledge of the p53-responsive SNP can inform diagnosis and prognosis of RSV disease and other diseases that might have a TLR8 component, including cancer.
|
31430261 |
2019 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
TLR8 agonists may synergize with cancer immunotherapeutic approaches to enhance the antitumor effects of the adaptive immune response.
|
29345064 |
2018 |